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@article{1319837,
author = {Filip, Pavel and Lungu, Ovidiu V. and Manto, MarioandUbaldo and Bareš, Martin},
article_location = {New York},
article_number = {6},
doi = {http://dx.doi.org/10.1007/s12311-015-0740-2},
keywords = {Cerebellum; Essential tremor; Dynamic oscillatory network; Electrophysiology},
language = {eng},
issn = {1473-4222},
journal = {Cerebellum},
title = {Linking Essential Tremor to the Cerebellum: Physiological Evidence},
volume = {15},
year = {2016}
}
TY - JOUR
ID - 1319837
AU - Filip, Pavel - Lungu, Ovidiu V. - Manto, Mario-Ubaldo - Bareš, Martin
PY - 2016
TI - Linking Essential Tremor to the Cerebellum: Physiological Evidence
JF - Cerebellum
VL - 15
IS - 6
SP - 774-780
EP - 774-780
PB - Springer
SN - 14734222
KW - Cerebellum
KW - Essential tremor
KW - Dynamic oscillatory network
KW - Electrophysiology
N2 - Essential tremor (ET), clinically characterized by postural and kinetic tremors, predominantly in the upper extremities, originates from pathological activity in the dynamic oscillatory network comprising the majority of nodes in the central motor network. Evidence indicates dysfunction in the thalamus, the olivocerebellar loops, and intermittent cortical engagement. Pathology of the cerebellum, a structure with architecture intrinsically predisposed to oscillatory activity, has also been implicated in ET as shown by clinical, neuroimaging, and pathological studies. Despite electrophysiological studies assessing cerebellar impairment in ET being scarce, their impact is tangible, as summarized in this review. The electromyography–magnetoencephalography combination provided the first direct evidence of pathological alteration in cortico-subcortical communication, with a significant emphasis on the cerebellum. Furthermore, complex electromyography studies showed disruptions in the timing of agonist and antagonist muscle activation, a process generally attributed to the cerebellum. Evidence pointing to cerebellar engagement in ET has also been found in electrooculography measurements, cerebellar repetitive transcranial magnetic stimulation studies, and, indirectly, in complex analyses of the activity of the ventral intermediate thalamic nucleus (an area primarily receiving inputs from the cerebellum), which is also used in the advanced treatment of ET. In summary, further progress in therapy will require comprehensive electrophysiological and physiological analyses to elucidate the precise mechanisms leading to disease symptoms. The cerebellum, as a major node of this dynamic oscillatory network, requires further study to aid this endeavor.
ER -
FILIP, Pavel, Ovidiu V. LUNGU, Mario-Ubaldo MANTO a Martin BAREŠ. Linking Essential Tremor to the Cerebellum: Physiological Evidence. \textit{Cerebellum}. New York: Springer, 2016, roč.~15, č.~6, s.~774-780. ISSN~1473-4222. Dostupné z: https://dx.doi.org/10.1007/s12311-015-0740-2.
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