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@proceedings{1320366,
author = {Křenová, Zdenka and Tvrdíková, Eliška and Štěrba, Jaroslav and Kodytková, Daniela and Křen, Leoš},
booktitle = {XXV. Konference dětských hematologů a onkologů České a Slovenské republiky},
keywords = {langerhans cell histiocytosis; non-classical immunomodulatory molecules; intrinsic immunoediting properties},
language = {eng},
isbn = {978-80-210-7958-8},
title = {Langerhans cell histiocytosis: intrinsic immunoediting properties},
year = {2015}
}
TY - CONF
ID - 1320366
AU - Křenová, Zdenka - Tvrdíková, Eliška - Štěrba, Jaroslav - Kodytková, Daniela - Křen, Leoš
PY - 2015
TI - Langerhans cell histiocytosis: intrinsic immunoediting properties
SN - 9788021079588
KW - langerhans cell histiocytosis
KW - non-classical immunomodulatory molecules
KW - intrinsic immunoediting properties
N2 - Non-classical HLA-molecules physiologically protect the fetus from maternal allorecognition, this mechanism seems to be used by some tumors during their development. PD-L1 is physiologically expressed mainly on antigen presenting cells, some types of tumors use this ligand to supress host immune reactions. The expression of non-classical immunomodulatory molecules (HLA-G, HLA-E, HLA-F) as well as the expression of immune checkpoint regulator programmed death ligand (PD-L1) is not characterized in Langerhans cell histiocytosis (LCH). Our data suggest that non-classical immunomodulatory molecules and immune checkpoint molecules may play role in immunoediting process during development of LCH. Further studies regarding immunoediting properties including non-classical HLA molecules and immune checkpoints ligands appear warranted for better understanding and therapy of this enigmatic disorder.
ER -
KŘENOVÁ, Zdenka, Eliška TVRDÍKOVÁ, Jaroslav ŠTĚRBA, Daniela KODYTKOVÁ a Leoš KŘEN. Langerhans cell histiocytosis: intrinsic immunoediting properties. In \textit{XXV. Konference dětských hematologů a onkologů České a Slovenské republiky}. 2015. ISBN~978-80-210-7958-8.
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