Oral Fat Sensing and CD36 Gene Polymorphism in Algerian Lean
and Obese Teenagers

J 2015

Oral Fat Sensing and CD36 Gene Polymorphism in Algerian Lean and Obese Teenagers

DAOUDI, Hadjer; Jiří PLESNÍK; Amira SAYED; Omar ŠERÝ; Abdelkader ROUABAH et al.

Základní údaje

Originální název

Oral Fat Sensing and CD36 Gene Polymorphism in Algerian Lean and Obese Teenagers

Autoři

DAOUDI, Hadjer; Jiří PLESNÍK; Amira SAYED; Omar ŠERÝ; Abdelkader ROUABAH; Leila ROUABAH a Naim Akhtar KHAN

Vydání

Nutrients, Switzerland, MDPI, 2015, 2072-6643

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30105 Physiology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.759

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/15:00085113

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

CD36; taste; obesity; adolescents; oleic acid

Štítky

AKR, rivok

Změněno: 2. 3. 2016 19:15, prof. RNDr. Omar Šerý, Ph.D.

Anotace

V originále

Growing number of evidences have suggested that oral fat sensing, mediated by a glycoprotein CD36 (cluster of differentiation 36), plays a significant role in the development of obesity. Indeed, a decreased expression of CD36 in some obese subjects is associated with high dietary fat intake. In the present study, we examined whether an increase in body mass index (BMI) is associated with altered oleic acid lingual detection thresholds and blood lipid profile in young Algerian teenagers (n = 165). The obese teenagers (n = 83; 14.01 ± 0.19 years; BMI z-score 2.67 ± 0.29) exhibited higher lingual detection threshold for oleic acid than lean participants (n = 82, 13.92 ± 0.23 years; BMI z-score 0.03 ± 0.0001). We also studied the association between rs1761667 polymorphism of CD36 gene and obesity. The AA and AG genotypes were more frequent in obese teenagers, whereas GG genotype was more common in lean participants. The A-allele frequency was higher in obese teenagers than that in lean children. We report that rs1761667 polymorphism of CD36 gene and oro-gustatory thresholds for fat might play a significant role in the development of obesity in young teenagers.

Citovat

DAOUDI, Hadjer; Jiří PLESNÍK; Amira SAYED; Omar ŠERÝ; Abdelkader ROUABAH; Leila ROUABAH a Naim Akhtar KHAN. Oral Fat Sensing and CD36 Gene Polymorphism in Algerian Lean and Obese Teenagers. Nutrients. Switzerland: MDPI, 2015, roč. 7, č. 11, s. 9096-9104. ISSN 2072-6643. Dostupné z: https://doi.org/10.3390/nu7115455.

@article{1320381,
   author = {Daoudi, Hadjer and Plesník, Jiří and Sayed, Amira and Šerý, Omar and Rouabah, Abdelkader and Rouabah, Leila and Khan, Naim Akhtar},
   article_location = {Switzerland},
   article_number = {11},
   doi = {https://doi.org/10.3390/nu7115455},
   keywords = {CD36; taste; obesity; adolescents; oleic acid},
   language = {eng},
   issn = {2072-6643},
   journal = {Nutrients},
   title = {Oral Fat Sensing and CD36 Gene Polymorphism in Algerian Lean and Obese Teenagers},
   volume = {7},
   year = {2015}
}

TY  - JOUR
ID  - 1320381
AU  - Daoudi, Hadjer - Plesník, Jiří - Sayed, Amira - Šerý, Omar - Rouabah, Abdelkader - Rouabah, Leila - Khan, Naim Akhtar
PY  - 2015
TI  - Oral Fat Sensing and CD36 Gene Polymorphism in Algerian Lean and Obese Teenagers
JF  - Nutrients
VL  - 7
IS  - 11
SP  - 9096-9104
EP  - 9096-9104
PB  - MDPI
SN  - 20726643
KW  - CD36
KW  - taste
KW  - obesity
KW  - adolescents
KW  - oleic acid
N2  - Growing number of evidences have suggested that oral fat sensing, mediated by a glycoprotein CD36 (cluster of differentiation 36), plays a significant role in the development of obesity. Indeed, a decreased expression of CD36 in some obese subjects is associated with high dietary fat intake. In the present study, we examined whether an increase in body mass index (BMI) is associated with altered oleic acid lingual detection thresholds and blood lipid profile in young Algerian teenagers (n = 165). The obese teenagers (n = 83; 14.01 ± 0.19 years; BMI z-score 2.67 ± 0.29) exhibited higher lingual detection threshold for oleic acid than lean participants (n = 82, 13.92 ± 0.23 years; BMI z-score 0.03 ± 0.0001). We also studied the association between rs1761667 polymorphism of CD36 gene and obesity. The AA and AG genotypes were more frequent in obese teenagers, whereas GG genotype was more common in lean participants. The A-allele frequency was higher in obese teenagers than that in lean children. We report that rs1761667 polymorphism of CD36 gene and oro-gustatory thresholds for fat might play a significant role in the development of obesity in young teenagers.
ER  -

DAOUDI, Hadjer; Jiří PLESNÍK; Amira SAYED; Omar ŠERÝ; Abdelkader ROUABAH; Leila ROUABAH a Naim Akhtar KHAN. Oral Fat Sensing and CD36 Gene Polymorphism in Algerian Lean and Obese Teenagers. \textit{Nutrients}. Switzerland: MDPI, 2015, roč.~7, č.~11, s.~9096-9104. ISSN~2072-6643. Dostupné z: https://doi.org/10.3390/nu7115455.

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