EGOM, Emmanuel E., Peter KRUŽLIAK, Vladimír ROTREKL a Ming LEI. The effect of the sphingosine-1-phosphate analogue FTY720 on atrioventricular nodal tissue. Journal of Cellular and Molecular Medicine. Hoboken: Wiley-Blackwell, 2015, roč. 19, č. 7, s. 1729-1734. ISSN 1582-4934. Dostupné z: https://dx.doi.org/10.1111/jcmm.12549.
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Základní údaje
Originální název The effect of the sphingosine-1-phosphate analogue FTY720 on atrioventricular nodal tissue
Autoři EGOM, Emmanuel E. (124 Kanada), Peter KRUŽLIAK (203 Česká republika), Vladimír ROTREKL (203 Česká republika, garant, domácí) a Ming LEI (826 Velká Británie a Severní Irsko).
Vydání Journal of Cellular and Molecular Medicine, Hoboken, Wiley-Blackwell, 2015, 1582-4934.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor Genetika a molekulární biologie
Stát vydavatele Spojené státy
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 4.938
Kód RIV RIV/00216224:14110/15:00085124
Organizační jednotka Lékařská fakulta
Doi http://dx.doi.org/10.1111/jcmm.12549
UT WoS 000357031200027
Klíčová slova anglicky fingolimod; atrioventricular node; sphingosine-1-phosphate
Štítky EL OK
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Ing. Mgr. Věra Pospíšilíková, učo 9005. Změněno: 30. 12. 2015 14:51.
Anotace
The sphingosine-1-phosphate (S1P) receptor modulator, fingolimod (FTY720), has been used for the treatment of patients with relapsing forms of multiple sclerosis, but atrioventricular (AV) conduction block have been reported in some patients after the first dose. The underlying mechanism of this AV node conduction blockade is still not well-understood. In this study, we hypothesize that expression of this particular arrhythmia might be related to a direct effect of FTY720 on AV node rather than a parasympathetic mimetic action. We, therefore, investigated the effect of FTY720 on AV nodal, using in vitro rat model preparation, under both basal as well as ischaemia/reperfusion conditions. We first look at the expression pattern of S1P receptors on the AV node using real-time PCR. Although all three S1P receptor isoforms were expressed in AVN tissues, S1P1 receptor isoform expression level was higher than S1P2 and S1P3. The effect of 25nM FTY720 on cycle length (CL) was subsequently studied via extracellular potentials recordings. FTY720 caused a mild to moderate prolongation in CL by an average 9% in AVN (n=10, P<0.05) preparations. We also show that FTY720 attenuated both ischaemia and reperfusion induced AVN rhythmic disturbance. To our knowledge, these remarkable findings have not been previously reported in the literature, and stress the importance for extensive monitoring period in certain cases, especially in patients taking concurrently AV node blocker agents.
VytisknoutZobrazeno: 19. 9. 2024 00:59