Computed Tomography Angiography With High Flow Rates An In
Vitro and In Vivo Feasibility Study

J 2015

Computed Tomography Angiography With High Flow Rates An In Vitro and In Vivo Feasibility Study

MIHL, Casper; Madeleine KOK; Joachim E. WILDBERGER; Jakub TUREK; Georg MUEHLENBRUCH et al.

Základní údaje

Originální název

Computed Tomography Angiography With High Flow Rates An In Vitro and In Vivo Feasibility Study

Autoři

MIHL, Casper; Madeleine KOK; Joachim E. WILDBERGER; Jakub TUREK; Georg MUEHLENBRUCH a Marco DAS

Vydání

Investigative Radiology, Philadelphia, Lippincott Williams & Wilkins, 2015, 0020-9996

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 4.887

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/15:00085178

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

attenuation; cannula; computed tomography; contrast media; flow injection analysis; injection; phantom

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 20. 1. 2016 15:52, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Objective The aims of this study were to test high-flow application of contrast media (CM) using novel high-flow needles and to assess injection- and flow-related parameters in a circulation phantom and in an in vivo population. Materials and Methods A circulation phantom simulating physiological parameters was used. Preheated CM (300 mg/mL) was injected at flow rates varying between 5 and 15 mL/s through a novel 18-gauge high-flow intravenous injection needle. In addition, feasibility of these high-flow needles was tested with administration of flow rates of 9 mL/s in 20 patients referred for pre-transcatheter aortic valve implantation assessment. Injection parameters (eg, peak pressures, peak flow rates) in both phantom and in vivo setup were continuously monitored by a data acquisition program. Attenuation at predefined levels of the aorta (eg, aortic root to common femoral arteries) was measured in all patients to determine clinical applicability. Results In the phantom setup, injection rates up to 15 mL/s were feasible. An enhancement plateau was reached at 11 mL/s (464 [20] HU). In patients, no pressure- or flow-related complications (eg, extravasation) were recorded (mean [SD] peak pressure, 154 [8] psi; mean [SD] peak flow rate, 9.2 [0.1 mL/s; range, 9.1-9.6]). Diagnostic attenuation values were reached at all predefined levels of the aorta (330.8 [113.1] HU to 622.9 [81.5] HU). Conclusions These results indicate that injections with 9 mL/s using high-flow injection needles are safe. The pressure limit of 325 psi was not reached, and the injections resulted in diagnostic attenuation values. Using this dedicated needle, high flow rates should not be considered a drawback for CM application in routine CT angiography examinations.

Citovat

MIHL, Casper; Madeleine KOK; Joachim E. WILDBERGER; Jakub TUREK; Georg MUEHLENBRUCH a Marco DAS. Computed Tomography Angiography With High Flow Rates An In Vitro and In Vivo Feasibility Study. Investigative Radiology. Philadelphia: Lippincott Williams & Wilkins, 2015, roč. 50, č. 7, s. 464-469. ISSN 0020-9996. Dostupné z: https://doi.org/10.1097/RLI.0000000000000153.

@article{1320642,
   author = {Mihl, Casper and Kok, Madeleine and Wildberger, Joachim E. and Turek, Jakub and Muehlenbruch, Georg and Das, Marco},
   article_location = {Philadelphia},
   article_number = {7},
   doi = {https://doi.org/10.1097/RLI.0000000000000153},
   keywords = {attenuation; cannula; computed tomography; contrast media; flow injection analysis; injection; phantom},
   language = {eng},
   issn = {0020-9996},
   journal = {Investigative Radiology},
   title = {Computed Tomography Angiography With High Flow Rates An In Vitro and In Vivo Feasibility Study},
   volume = {50},
   year = {2015}
}

TY  - JOUR
ID  - 1320642
AU  - Mihl, Casper - Kok, Madeleine - Wildberger, Joachim E. - Turek, Jakub - Muehlenbruch, Georg - Das, Marco
PY  - 2015
TI  - Computed Tomography Angiography With High Flow Rates An In Vitro and In Vivo Feasibility Study
JF  - Investigative Radiology
VL  - 50
IS  - 7
SP  - 464-469
EP  - 464-469
PB  - Lippincott Williams & Wilkins
SN  - 00209996
KW  - attenuation
KW  - cannula
KW  - computed tomography
KW  - contrast media
KW  - flow injection analysis
KW  - injection
KW  - phantom
N2  - Objective The aims of this study were to test high-flow application of contrast media (CM) using novel high-flow needles and to assess injection- and flow-related parameters in a circulation phantom and in an in vivo population. Materials and Methods A circulation phantom simulating physiological parameters was used. Preheated CM (300 mg/mL) was injected at flow rates varying between 5 and 15 mL/s through a novel 18-gauge high-flow intravenous injection needle. In addition, feasibility of these high-flow needles was tested with administration of flow rates of 9 mL/s in 20 patients referred for pre-transcatheter aortic valve implantation assessment. Injection parameters (eg, peak pressures, peak flow rates) in both phantom and in vivo setup were continuously monitored by a data acquisition program. Attenuation at predefined levels of the aorta (eg, aortic root to common femoral arteries) was measured in all patients to determine clinical applicability. Results In the phantom setup, injection rates up to 15 mL/s were feasible. An enhancement plateau was reached at 11 mL/s (464 [20] HU). In patients, no pressure- or flow-related complications (eg, extravasation) were recorded (mean [SD] peak pressure, 154 [8] psi; mean [SD] peak flow rate, 9.2 [0.1 mL/s; range, 9.1-9.6]). Diagnostic attenuation values were reached at all predefined levels of the aorta (330.8 [113.1] HU to 622.9 [81.5] HU). Conclusions These results indicate that injections with 9 mL/s using high-flow injection needles are safe. The pressure limit of 325 psi was not reached, and the injections resulted in diagnostic attenuation values. Using this dedicated needle, high flow rates should not be considered a drawback for CM application in routine CT angiography examinations.
ER  -

MIHL, Casper; Madeleine KOK; Joachim E. WILDBERGER; Jakub TUREK; Georg MUEHLENBRUCH a Marco DAS. Computed Tomography Angiography With High Flow Rates An In Vitro and In Vivo Feasibility Study. \textit{Investigative Radiology}. Philadelphia: Lippincott Williams \&{} Wilkins, 2015, roč.~50, č.~7, s.~464-469. ISSN~0020-9996. Dostupné z: https://doi.org/10.1097/RLI.0000000000000153.

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