The impact of thyroid hormone replacement therapy on left
ventricular diastolic function in patients with subclinical
hypothyroidism

J 2016

The impact of thyroid hormone replacement therapy on left ventricular diastolic function in patients with subclinical hypothyroidism

SHATYNSKA‑MYTSYK, I.; L. RODRIGO; R. CIOCCOCIOPPO; D. PETROVIC; N. LAKUSIC et al.

Základní údaje

Originální název

The impact of thyroid hormone replacement therapy on left ventricular diastolic function in patients with subclinical hypothyroidism

Autoři

SHATYNSKA‑MYTSYK, I.; L. RODRIGO; R. CIOCCOCIOPPO; D. PETROVIC; N. LAKUSIC; L. COMPOSTELLA; Miroslav NOVÁK a Peter KRUŽLIAK

Vydání

Journal of Endocrinological Investigation, New York, Springer, 2016, 1720-8386

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/16:00089225

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Subclinical hypothyroidism; Echocardiography; Left ventricular diastolic function; Heart failure

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 8. 2016 08:23, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Objective Subclinical hypothyroidism (SH) is associated with a moderately elevated risk of heart failure events among older adults. The objective of our prospective study was to assess the impact of thyroid hormone replacement therapy (HRT) with low doses of l-thyroxine (6.25-25 mu g/day) on left ventricular diastolic function in patients with SH. Materials and methods 33 patients with SH and 25 healthy controls were involved. All participants underwent standard echocardiography and Doppler imaging at baseline and, the patient group, also after a course of HRT. Results At baseline, patients with SH showed significantly lower E (0.79 +/- 0.22 vs. 0.93 +/- 0.19, p < 0.001), E/A ratio (1.19 +/- 0.29 vs. 1.31 +/- 0.25, p < 0.003), and higher intraventricular septum thickness (IVST) (0.99 +/- 0.14 vs. 0.89 +/- 0.18, p < 0.001) in comparison with healthy controls. After 6 months of therapy, the E/A ratio underwent significant increase (1.28 +/- 0.21 vs. 1.19 +/- 0.29, p < 0.001), while the IVS displayed a robust reduction (0.92 +/- 0.16 vs. 0.99 +/- 0.14, p < 0.001). Conclusions HRT with low-dosed l-thyroxine may improve left ventricular diastolic function in patients with SH.

Citovat

SHATYNSKA‑MYTSYK, I.; L. RODRIGO; R. CIOCCOCIOPPO; D. PETROVIC; N. LAKUSIC; L. COMPOSTELLA; Miroslav NOVÁK a Peter KRUŽLIAK. The impact of thyroid hormone replacement therapy on left ventricular diastolic function in patients with subclinical hypothyroidism. Journal of Endocrinological Investigation. New York: Springer, 2016, roč. 39, č. 6, s. 709-713. ISSN 1720-8386. Dostupné z: https://doi.org/10.1007/s40618-015-0262-2.

@article{1322327,
   author = {Shatynska‑Mytsyk, I. and Rodrigo, L. and Cioccocioppo, R. and Petrovic, D. and Lakusic, N. and Compostella, L. and Novák, Miroslav and Kružliak, Peter},
   article_location = {New York},
   article_number = {6},
   doi = {https://doi.org/10.1007/s40618-015-0262-2},
   keywords = {Subclinical hypothyroidism; Echocardiography; Left ventricular diastolic function; Heart failure},
   language = {eng},
   issn = {1720-8386},
   journal = {Journal of Endocrinological Investigation},
   title = {The impact of thyroid hormone replacement therapy on left ventricular diastolic function in patients with subclinical hypothyroidism},
   volume = {39},
   year = {2016}
}

TY  - JOUR
ID  - 1322327
AU  - Shatynska‑Mytsyk, I. - Rodrigo, L. - Cioccocioppo, R. - Petrovic, D. - Lakusic, N. - Compostella, L. - Novák, Miroslav - Kružliak, Peter
PY  - 2016
TI  - The impact of thyroid hormone replacement therapy on left ventricular diastolic function in patients with subclinical hypothyroidism
JF  - Journal of Endocrinological Investigation
VL  - 39
IS  - 6
SP  - 709-713
EP  - 709-713
PB  - Springer
SN  - 17208386
KW  - Subclinical hypothyroidism
KW  - Echocardiography
KW  - Left ventricular diastolic function
KW  - Heart failure
N2  - Objective Subclinical hypothyroidism (SH) is associated with a moderately elevated risk of heart failure events among older adults. The objective of our prospective study was to assess the impact of thyroid hormone replacement therapy (HRT) with low doses of l-thyroxine (6.25-25 mu g/day) on left ventricular diastolic function in patients with SH. Materials and methods 33 patients with SH and 25 healthy controls were involved. All participants underwent standard echocardiography and Doppler imaging at baseline and, the patient group, also after a course of HRT. Results At baseline, patients with SH showed significantly lower E (0.79 +/- 0.22 vs. 0.93 +/- 0.19, p < 0.001), E/A ratio (1.19 +/- 0.29 vs. 1.31 +/- 0.25, p < 0.003), and higher intraventricular septum thickness (IVST) (0.99 +/- 0.14 vs. 0.89 +/- 0.18, p < 0.001) in comparison with healthy controls. After 6 months of therapy, the E/A ratio underwent significant increase (1.28 +/- 0.21 vs. 1.19 +/- 0.29, p < 0.001), while the IVS displayed a robust reduction (0.92 +/- 0.16 vs. 0.99 +/- 0.14, p < 0.001). Conclusions HRT with low-dosed l-thyroxine may improve left ventricular diastolic function in patients with SH.
ER  -

SHATYNSKA‑MYTSYK, I.; L. RODRIGO; R. CIOCCOCIOPPO; D. PETROVIC; N. LAKUSIC; L. COMPOSTELLA; Miroslav NOVÁK a Peter KRUŽLIAK. The impact of thyroid hormone replacement therapy on left ventricular diastolic function in patients with subclinical hypothyroidism. \textit{Journal of Endocrinological Investigation}. New York: Springer, 2016, roč.~39, č.~6, s.~709-713. ISSN~1720-8386. Dostupné z: https://doi.org/10.1007/s40618-015-0262-2.

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