Kite Proteins: a Superfamily of SMC/Kleisin Partners Conserved
Across Bacteria, Archaea, and Eukaryotes

J 2015

Kite Proteins: a Superfamily of SMC/Kleisin Partners Conserved Across Bacteria, Archaea, and Eukaryotes

PALEČEK, Jan a Stephan GRUBER

Základní údaje

Originální název

Kite Proteins: a Superfamily of SMC/Kleisin Partners Conserved Across Bacteria, Archaea, and Eukaryotes

Název česky

KITE proteiny: Superrodina SMC/kleisin partnerů konzervovaná v bakteriích, archea a eukaryotech

Autoři

PALEČEK, Jan a Stephan GRUBER

Vydání

Structure, CAMBRIDGE, CELL PRESS, 2015, 0969-2126

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.237

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14740/15:00081379

Organizační jednotka

Středoevropský technologický institut

Klíčová slova anglicky

SMC structural maintenance of chromosomes; Cohesin; Condensin; Smc5/6; MukBEF; MksBEF; MAGE; Smc/ScpAB; kleisin; chromosome segregation; cohesion; condensation; replication; winged helix domains; kite proteins

Štítky

MAGE proteins, rivok, SMC5-6 complex

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 20. 1. 2017 11:34, doc. Mgr. Jan Paleček, Dr. rer. nat.

Anotace

V originále

SMC/kleisin complexes form elongated annular structures, which are critical for chromosome segregation, genome maintenance, and the regulation of gene expression. We describe marked structural similarities between bacterial and eukaryotic SMC/kleisin partner proteins (designated here as "kite'' proteins for kleisin interacting tandem winged-helix (WH) elements of SMC complexes). Kite proteins are integral parts of all prokaryotic SMC complexes and Smc5/6 but not cohesin and condensin. They are made up of tandem WH domains, form homo-or heterodimers via their amino-terminal WH domain, and they associate with the central part of a kleisin subunit. In placental mammals, the kite subunit NSE3 gave rise to several (>60) kite-related proteins, named MAGE, many of which encode tumor-and testis-specific antigens. Based on architectural rather than sequence similarity, we propose an adapted model for the evolution of the SMC protein complexes and discuss potential functional similarities between bacterial Smc/ScpAB and eukaryotic Smc5/6.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

GA13-00774S, projekt VaV

Název: Úloha proteinů Nse, podjednotek komplexu SMC5/6, v procesech stabilizujících pozastavené replikační vidlice

Investor: Grantová agentura ČR, Úloha proteinu Nse, podjednotek komplexu SMC5/6, v procesech stabilizujících pozastavené replikacní vidlice

Citovat

PALEČEK, Jan a Stephan GRUBER. Kite Proteins: a Superfamily of SMC/Kleisin Partners Conserved Across Bacteria, Archaea, and Eukaryotes. Structure. CAMBRIDGE: CELL PRESS, 2015, roč. 23, č. 12, s. 2183-2190. ISSN 0969-2126. Dostupné z: https://doi.org/10.1016/j.str.2015.10.004.

@article{1322637,
   author = {Paleček, Jan and Gruber, Stephan},
   article_location = {CAMBRIDGE},
   article_number = {12},
   doi = {https://doi.org/10.1016/j.str.2015.10.004},
   keywords = {SMC structural maintenance of chromosomes; Cohesin; Condensin; Smc5/6; MukBEF; MksBEF; MAGE; Smc/ScpAB; kleisin; chromosome segregation; cohesion; condensation; replication; winged helix domains; kite proteins},
   language = {eng},
   issn = {0969-2126},
   journal = {Structure},
   title = {Kite Proteins: a Superfamily of SMC/Kleisin Partners Conserved Across Bacteria, Archaea, and Eukaryotes},
   url = {http://www.sciencedirect.com/science/article/pii/S0969212615004128},
   volume = {23},
   year = {2015}
}

TY  - JOUR
ID  - 1322637
AU  - Paleček, Jan - Gruber, Stephan
PY  - 2015
TI  - Kite Proteins: a Superfamily of SMC/Kleisin Partners Conserved Across Bacteria, Archaea, and Eukaryotes
JF  - Structure
VL  - 23
IS  - 12
SP  - 2183-2190
EP  - 2183-2190
PB  - CELL PRESS
SN  - 09692126
KW  - SMC structural maintenance of chromosomes
KW  - Cohesin
KW  - Condensin
KW  - Smc5/6
KW  - MukBEF
KW  - MksBEF
KW  - MAGE
KW  - Smc/ScpAB
KW  - kleisin
KW  - chromosome segregation
KW  - cohesion
KW  - condensation
KW  - replication
KW  - winged helix domains
KW  - kite proteins
UR  - http://www.sciencedirect.com/science/article/pii/S0969212615004128
L2  - http://www.sciencedirect.com/science/article/pii/S0969212615004128
N2  - SMC/kleisin complexes form elongated annular structures, which are critical for chromosome segregation, genome maintenance, and the regulation of gene expression. We describe marked structural similarities between bacterial and eukaryotic SMC/kleisin partner proteins (designated here as "kite'' proteins for kleisin interacting tandem winged-helix (WH) elements of SMC complexes). Kite proteins are integral parts of all prokaryotic SMC complexes and Smc5/6 but not cohesin and condensin. They are made up of tandem WH domains, form homo-or heterodimers via their amino-terminal WH domain, and they associate with the central part of a kleisin subunit. In placental mammals, the kite subunit NSE3 gave rise to several (>60) kite-related proteins, named MAGE, many of which encode tumor-and testis-specific antigens. Based on architectural rather than sequence similarity, we propose an adapted model for the evolution of the SMC protein complexes and discuss potential functional similarities between bacterial Smc/ScpAB and eukaryotic Smc5/6.
ER  -

PALEČEK, Jan a Stephan GRUBER. Kite Proteins: a Superfamily of SMC/Kleisin Partners Conserved Across Bacteria, Archaea, and Eukaryotes. \textit{Structure}. CAMBRIDGE: CELL PRESS, 2015, roč.~23, č.~12, s.~2183-2190. ISSN~0969-2126. Dostupné z: https://doi.org/10.1016/j.str.2015.10.004.

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