Positive Influence of Being Overweight/Obese on Long Term
Survival in Patients Hospitalised Due to Acute Heart Failure

J 2015

Positive Influence of Being Overweight/Obese on Long Term Survival in Patients Hospitalised Due to Acute Heart Failure

LITTNEROVÁ, Simona; Jiří PAŘENICA; Jindřich ŠPINAR; Jiří VÍTOVEC; Ales LINHART et al.

Základní údaje

Originální název

Positive Influence of Being Overweight/Obese on Long Term Survival in Patients Hospitalised Due to Acute Heart Failure

Autoři

Vydání

Plos one, San Francisco, Public Library of Science, 2015, 1932-6203

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.057

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/15:00085555

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1371/journal.pone.0117142

UT WoS

000350683900023

EID Scopus

2-s2.0-84923372902

Klíčová slova anglicky

BODY-MASS INDEX; ACUTE MYOCARDIAL-INFARCTION; ACUTE CORONARY SYNDROMES; OBESITY PARADOX; RISK-FACTORS; MORTALITY; ASSOCIATION; REGISTRY; ADIPOCYTOKINE; GUIDELINES

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 5. 1. 2016 15:02, Soňa Böhmová

Anotace

V originále

Background Obesity is clearly associated with increased morbidity and mortality rates. However, in patients with acute heart failure (AHF), an increased BMI could represent a protective marker. Studies evaluating the "obesity paradox" on a large cohort with long-term follow-up are lacking. Methods Using the AHEAD database (a Czech multi-centre database of patients hospitalised due to AHF), 5057 patients were evaluated; patients with a BMI <18.5 kg/m(2) were excluded. All cause mortality was compared between groups with a BMI of 18.5-25 kg/m(2) and with BMI >25 kg/m(2). Data were adjusted by a propensity score for 11 parameters. Results In the balanced groups, the difference in 30-day mortality was not significant. The long-term mortality of patients with normal weight was higher than for those who were overweight/obese (HR, 1.36; 95% CI, 1.26-1.48; p<0.001)). In the balanced dataset, the pattern was similar (1.22; 1.09-1.39; p<0.001). A similar result was found in the balanced dataset of a subgroup of patients with de novo AHF (1.30; 1.11-1.52; p = 0.001), but only a trend in a balanced dataset of patients with acute decompensated heart failure. Conclusion These data suggest significantly lower long-term mortality in overweight/obese patients with AHF. The results suggest that at present there is no evidence for weight reduction in overweight/obese patients with heart failure, and emphasize the importance of prevention of cardiac cachexia.

Návaznosti

MUNI/A/1012/2013, interní kód MU

Název: Diagnostika akutní myokarditidy mimikující akutní infarkt myokardu s ST elevacemi

Investor: Masarykova univerzita, Diagnostika akutní myokarditidy mimikující akutní infarkt myokardu s ST elevacemi, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

LITTNEROVÁ, Simona; Jiří PAŘENICA; Jindřich ŠPINAR; Jiří VÍTOVEC; Ales LINHART; Petr WIDIMSKÝ; Jiří JARKOVSKÝ; Roman MIKLÍK; Lenka ŠPINAROVÁ; Kamil ZEMAN; Jan BELOHLAVEK; Filip MALEK; Marián FELŠŐCI; Jiří KETTNER; Petr OSTADAL; Cestmir CIHALIK; Jiří ŠPÁC; Hikmet AL-HITI; Marian FEDORCO; Richard FOJT; Andreas KRUGER; Josef MALEK; Tereza MIKUŠOVÁ; Zdenek MONHART; Stanislava BOHACOVA; Lidka POHLUDKOVA; Filip ROHAC; Jan VACLAVIK; Dagmar VONDRAKOVA; Klaudia VYSKOČILOVÁ; Miroslav BAMBUCH a Ladislav DUŠEK. Positive Influence of Being Overweight/Obese on Long Term Survival in Patients Hospitalised Due to Acute Heart Failure. Plos one. San Francisco: Public Library of Science, 2015, roč. 10, č. 2, s. "e0117142", 15 s. ISSN 1932-6203. Dostupné z: https://doi.org/10.1371/journal.pone.0117142.

@article{1322847,
   author = {Littnerová, Simona and Pařenica, Jiří and Špinar, Jindřich and Vítovec, Jiří and Linhart, Ales and Widimský, Petr and Jarkovský, Jiří and Miklík, Roman and Špinarová, Lenka and Zeman, Kamil and Belohlavek, Jan and Malek, Filip and Felšőci, Marián and Kettner, Jiří and Ostadal, Petr and Cihalik, Cestmir and Špác, Jiří and AlandHiti, Hikmet and Fedorco, Marian and Fojt, Richard and Kruger, Andreas and Malek, Josef and Mikušová, Tereza and Monhart, Zdenek and Bohacova, Stanislava and Pohludkova, Lidka and Rohac, Filip and Vaclavik, Jan and Vondrakova, Dagmar and Vyskočilová, Klaudia and Bambuch, Miroslav and Dušek, Ladislav},
   article_location = {San Francisco},
   article_number = {2},
   doi = {https://doi.org/10.1371/journal.pone.0117142},
   keywords = {BODY-MASS INDEX; ACUTE MYOCARDIAL-INFARCTION; ACUTE CORONARY SYNDROMES; OBESITY PARADOX; RISK-FACTORS; MORTALITY; ASSOCIATION; REGISTRY; ADIPOCYTOKINE; GUIDELINES},
   language = {eng},
   issn = {1932-6203},
   journal = {Plos one},
   title = {Positive Influence of Being Overweight/Obese on Long Term Survival in Patients Hospitalised Due to Acute Heart Failure},
   volume = {10},
   year = {2015}
}

TY  - JOUR
ID  - 1322847
AU  - Littnerová, Simona - Pařenica, Jiří - Špinar, Jindřich - Vítovec, Jiří - Linhart, Ales - Widimský, Petr - Jarkovský, Jiří - Miklík, Roman - Špinarová, Lenka - Zeman, Kamil - Belohlavek, Jan - Malek, Filip - Felšőci, Marián - Kettner, Jiří - Ostadal, Petr - Cihalik, Cestmir - Špác, Jiří - Al-Hiti, Hikmet - Fedorco, Marian - Fojt, Richard - Kruger, Andreas - Malek, Josef - Mikušová, Tereza - Monhart, Zdenek - Bohacova, Stanislava - Pohludkova, Lidka - Rohac, Filip - Vaclavik, Jan - Vondrakova, Dagmar - Vyskočilová, Klaudia - Bambuch, Miroslav - Dušek, Ladislav
PY  - 2015
TI  - Positive Influence of Being Overweight/Obese on Long Term Survival in Patients Hospitalised Due to Acute Heart Failure
JF  - Plos one
VL  - 10
IS  - 2
SP  - "e0117142"
EP  - "e0117142"
PB  - Public Library of Science
SN  - 19326203
KW  - BODY-MASS INDEX
KW  - ACUTE MYOCARDIAL-INFARCTION
KW  - ACUTE CORONARY SYNDROMES
KW  - OBESITY PARADOX
KW  - RISK-FACTORS
KW  - MORTALITY
KW  - ASSOCIATION
KW  - REGISTRY
KW  - ADIPOCYTOKINE
KW  - GUIDELINES
N2  - Background Obesity is clearly associated with increased morbidity and mortality rates. However, in patients with acute heart failure (AHF), an increased BMI could represent a protective marker. Studies evaluating the "obesity paradox" on a large cohort with long-term follow-up are lacking. Methods Using the AHEAD database (a Czech multi-centre database of patients hospitalised due to AHF), 5057 patients were evaluated; patients with a BMI <18.5 kg/m(2) were excluded. All cause mortality was compared between groups with a BMI of 18.5-25 kg/m(2) and with BMI >25 kg/m(2). Data were adjusted by a propensity score for 11 parameters. Results In the balanced groups, the difference in 30-day mortality was not significant. The long-term mortality of patients with normal weight was higher than for those who were overweight/obese (HR, 1.36; 95% CI, 1.26-1.48; p<0.001)). In the balanced dataset, the pattern was similar (1.22; 1.09-1.39; p<0.001). A similar result was found in the balanced dataset of a subgroup of patients with de novo AHF (1.30; 1.11-1.52; p = 0.001), but only a trend in a balanced dataset of patients with acute decompensated heart failure. Conclusion These data suggest significantly lower long-term mortality in overweight/obese patients with AHF. The results suggest that at present there is no evidence for weight reduction in overweight/obese patients with heart failure, and emphasize the importance of prevention of cardiac cachexia.
ER  -

LITTNEROVÁ, Simona; Jiří PAŘENICA; Jindřich ŠPINAR; Jiří VÍTOVEC; Ales LINHART; Petr WIDIMSKÝ; Jiří JARKOVSKÝ; Roman MIKLÍK; Lenka ŠPINAROVÁ; Kamil ZEMAN; Jan BELOHLAVEK; Filip MALEK; Marián FELŠ$\backslash$H OCI; Jiří KETTNER; Petr OSTADAL; Cestmir CIHALIK; Jiří ŠPÁC; Hikmet AL-HITI; Marian FEDORCO; Richard FOJT; Andreas KRUGER; Josef MALEK; Tereza MIKUŠOVÁ; Zdenek MONHART; Stanislava BOHACOVA; Lidka POHLUDKOVA; Filip ROHAC; Jan VACLAVIK; Dagmar VONDRAKOVA; Klaudia VYSKOČILOVÁ; Miroslav BAMBUCH a Ladislav DUŠEK. Positive Influence of Being Overweight/Obese on Long Term Survival in Patients Hospitalised Due to Acute Heart Failure. \textit{Plos one}. San Francisco: Public Library of Science, 2015, roč.~10, č.~2, s.~''e0117142'', 15 s. ISSN~1932-6203. Dostupné z: https://doi.org/10.1371/journal.pone.0117142.

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