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@article{1322928,
author = {Stejskal, Stanislav and Štěpka, Karel and Tesařová, Lenka and Stejskal, Karel and Matějková, Martina and Šimara, Pavel and Zdráhal, Zbyněk and Krontorád Koutná, Irena},
article_location = {Philadelphia},
article_number = {24},
doi = {http://dx.doi.org/10.1080/15384101.2015.1106760},
keywords = {Cell cycle; Chromatin; DNA replication; H3K56ac; Mammalian cells; Nucleosome},
language = {eng},
issn = {1538-4101},
journal = {Cell Cycle},
title = {Cell cycle-dependent changes in H3K56ac in human cells.},
url = {http://www.tandfonline.com/doi/abs/10.1080/15384101.2015.1106760},
volume = {14},
year = {2015}
}
TY - JOUR
ID - 1322928
AU - Stejskal, Stanislav - Štěpka, Karel - Tesařová, Lenka - Stejskal, Karel - Matějková, Martina - Šimara, Pavel - Zdráhal, Zbyněk - Krontorád Koutná, Irena
PY - 2015
TI - Cell cycle-dependent changes in H3K56ac in human cells.
JF - Cell Cycle
VL - 14
IS - 24
SP - 3851-3863
EP - 3851-3863
PB - Taylor&Francis Inc
SN - 15384101
KW - Cell cycle
KW - Chromatin
KW - DNA replication
KW - H3K56ac
KW - Mammalian cells
KW - Nucleosome
UR - http://www.tandfonline.com/doi/abs/10.1080/15384101.2015.1106760
L2 - http://www.tandfonline.com/doi/abs/10.1080/15384101.2015.1106760
N2 - The incorporation of histone H3 with an acetylated lysine 56 (H3K56ac) into the nucleosome is important for chromatin remodeling and serves as a marker of new nucleosomes during DNA replication and repair in yeast. However, in human cells, the level of H3K56ac is greatly reduced, and its role during the cell cycle is controversial. Our aim was to determine the potential of H3K56ac to regulate cell cycle progression in different human cell lines. A significant increase in the number of H3K56ac foci, but not in H3K56ac protein levels, was observed during the S and G2 phases in cancer cell lines, but was not observed in embryonic stem cell lines. Despite this increase, the H3K56ac signal was not present in late replication chromatin, and H3K56ac protein levels did not decrease after the inhibition of DNA replication. H3K56ac was not tightly associated with the chromatin and was primarily localized to active chromatin regions. Our results support the role of H3K56ac in transcriptionally active chromatin areas but do not confirm H3K56ac as a marker of newly synthetized nucleosomes in DNA replication.
ER -
STEJSKAL, Stanislav, Karel ŠTĚPKA, Lenka TESAŘOVÁ, Karel STEJSKAL, Martina MATĚJKOVÁ, Pavel ŠIMARA, Zbyněk ZDRÁHAL a Irena KRONTORÁD KOUTNÁ. Cell cycle-dependent changes in H3K56ac in human cells. \textit{Cell Cycle}. Philadelphia: Taylor\&{}Francis Inc, 2015, roč.~14, č.~24, s.~3851-3863. ISSN~1538-4101. Dostupné z: https://dx.doi.org/10.1080/15384101.2015.1106760.
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