Clinical Role of Atrial Arrhythmias in Patients With
Arrhythmogenic Right Ventricular Dysplasia

J 2014

Clinical Role of Atrial Arrhythmias in Patients With Arrhythmogenic Right Ventricular Dysplasia

SAGUNER, AM; S GANAHL; Andrea KRAUS; SH BALDINGER; A MEDEIROS-DOMINGO et al.

Základní údaje

Originální název

Clinical Role of Atrial Arrhythmias in Patients With Arrhythmogenic Right Ventricular Dysplasia

Autoři

SAGUNER, AM; S GANAHL; Andrea KRAUS; SH BALDINGER; A MEDEIROS-DOMINGO; AR SAGUNER; SA MUELLER-BURRI; T WOLBER; LM HAEGELI; N KRASNIQI; FC TANNER; J STEFFEL; C BRUNCKHORST a F DURU

Vydání

Circulation Journal, Tokyo, Japanese Circulation Soc, 2014, 1346-9843

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.940

Označené pro přenos do RIV

DOI

https://doi.org/10.1253/circj.CJ-14-0474

UT WoS

000346698300013

Klíčová slova anglicky

Arrhythmogenic right ventricular dysplasia; Atrial fibrillation; Atrial flutter; Cardiomyopathy

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 1. 2016 23:07, Mgr. Andrea Kraus, M.Sc., Ph.D.

Anotace

V originále

Background: The clinical role of atrial fibrillation/atrial flutter (AF-AFl) and variables predicting these arrhythmias are not well defined in patients with arrhythmogenic right ventricular dysplasia (ARVD). We hypothesized that transthoracic echocardiography (TTE) and 12-lead electrocardiography (ECG) would be helpful in predicting AF-AFl in these patients. Methods and Results: ECGs and TTEs of 90 patients diagnosed with definite or borderline ARVD (2010 Task Force Criteria) were analyzed. Data were compared in (1) patients with AF-AFl and (2) all other patients. A total of 18 (20%) patients experienced AF-AFl during a median follow-up of 5.8 years (interquartile range 2.0-10.4). Kaplan-Meier analysis revealed reduced times to AF-AFl among patients with echocardiographic RV fractional area change <27% (P<0.001), left atrial diameter >= 24.4 mm/m(2) (parasternal long-axis, P=0.001), and right atrial short-axis diameter >= 22.1 mm/m(2) (apical 4-chamber view, P=0.05). From all ECG variables, P mitrale conferred the highest hazard ratio (3.37, 95% confidence interval 0.92-12.36, P=0.067). Five patients with AF-AFl experienced inappropriate implantable cardioverter-defibrillator (ICD) shocks compared with 4 without AF-AFl (36% vs. 9%, P=0.03). AF-AFl was more prevalent in heart-transplant patients and those who died of cardiac causes (56% vs. 16%, P=0.014). Conclusions: AF-AFl is associated with inappropriate ICD shocks, heart transplantation, and cardiac death in patients with ARVD. Evidence of reduced RV function and atrial dilation helps to identify the ARVD patients at increased risk for AF-AFl.

Citovat

SAGUNER, AM; S GANAHL; Andrea KRAUS; SH BALDINGER; A MEDEIROS-DOMINGO; AR SAGUNER; SA MUELLER-BURRI; T WOLBER; LM HAEGELI; N KRASNIQI; FC TANNER; J STEFFEL; C BRUNCKHORST a F DURU. Clinical Role of Atrial Arrhythmias in Patients With Arrhythmogenic Right Ventricular Dysplasia. Circulation Journal. Tokyo: Japanese Circulation Soc, 2014, roč. 78, č. 12, s. 2854-2861. ISSN 1346-9843. Dostupné z: https://doi.org/10.1253/circj.CJ-14-0474.

@article{1324041,
   author = {Saguner, AM and Ganahl, S and Kraus, Andrea and Baldinger, SH and MedeirosandDomingo, A and Saguner, AR and MuellerandBurri, SA and Wolber, T and Haegeli, LM and Krasniqi, N and Tanner, FC and Steffel, J and Brunckhorst, C and Duru, F},
   article_location = {Tokyo},
   article_number = {12},
   doi = {https://doi.org/10.1253/circj.CJ-14-0474},
   keywords = {Arrhythmogenic right ventricular dysplasia; Atrial fibrillation; Atrial flutter; Cardiomyopathy},
   language = {eng},
   issn = {1346-9843},
   journal = {Circulation Journal},
   title = {Clinical Role of Atrial Arrhythmias in Patients With Arrhythmogenic Right Ventricular Dysplasia},
   volume = {78},
   year = {2014}
}

TY  - JOUR
ID  - 1324041
AU  - Saguner, AM - Ganahl, S - Kraus, Andrea - Baldinger, SH - Medeiros-Domingo, A - Saguner, AR - Mueller-Burri, SA - Wolber, T - Haegeli, LM - Krasniqi, N - Tanner, FC - Steffel, J - Brunckhorst, C - Duru, F
PY  - 2014
TI  - Clinical Role of Atrial Arrhythmias in Patients With Arrhythmogenic Right Ventricular Dysplasia
JF  - Circulation Journal
VL  - 78
IS  - 12
SP  - 2854-2861
EP  - 2854-2861
PB  - Japanese Circulation Soc
SN  - 13469843
KW  - Arrhythmogenic right ventricular dysplasia
KW  - Atrial fibrillation
KW  - Atrial flutter
KW  - Cardiomyopathy
N2  - Background: The clinical role of atrial fibrillation/atrial flutter (AF-AFl) and variables predicting these arrhythmias are not well defined in patients with arrhythmogenic right ventricular dysplasia (ARVD). We hypothesized that transthoracic echocardiography (TTE) and 12-lead electrocardiography (ECG) would be helpful in predicting AF-AFl in these patients. Methods and Results: ECGs and TTEs of 90 patients diagnosed with definite or borderline ARVD (2010 Task Force Criteria) were analyzed. Data were compared in (1) patients with AF-AFl and (2) all other patients. A total of 18 (20%) patients experienced AF-AFl during a median follow-up of 5.8 years (interquartile range 2.0-10.4). Kaplan-Meier analysis revealed reduced times to AF-AFl among patients with echocardiographic RV fractional area change <27% (P<0.001), left atrial diameter >= 24.4 mm/m(2) (parasternal long-axis, P=0.001), and right atrial short-axis diameter >= 22.1 mm/m(2) (apical 4-chamber view, P=0.05). From all ECG variables, P mitrale conferred the highest hazard ratio (3.37, 95% confidence interval 0.92-12.36, P=0.067). Five patients with AF-AFl experienced inappropriate implantable cardioverter-defibrillator (ICD) shocks compared with 4 without AF-AFl (36% vs. 9%, P=0.03). AF-AFl was more prevalent in heart-transplant patients and those who died of cardiac causes (56% vs. 16%, P=0.014). Conclusions: AF-AFl is associated with inappropriate ICD shocks, heart transplantation, and cardiac death in patients with ARVD. Evidence of reduced RV function and atrial dilation helps to identify the ARVD patients at increased risk for AF-AFl.
ER  -

SAGUNER, AM; S GANAHL; Andrea KRAUS; SH BALDINGER; A MEDEIROS-DOMINGO; AR SAGUNER; SA MUELLER-BURRI; T WOLBER; LM HAEGELI; N KRASNIQI; FC TANNER; J STEFFEL; C BRUNCKHORST a F DURU. Clinical Role of Atrial Arrhythmias in Patients With Arrhythmogenic Right Ventricular Dysplasia. \textit{Circulation Journal}. Tokyo: Japanese Circulation Soc, 2014, roč.~78, č.~12, s.~2854-2861. ISSN~1346-9843. Dostupné z: https://doi.org/10.1253/circj.CJ-14-0474.

Přehled o publikaci