Electrocardiographic features of disease progression in
arrhythmogenic right ventricular cardiomyopathy/dysplasia

J 2015

Electrocardiographic features of disease progression in arrhythmogenic right ventricular cardiomyopathy/dysplasia

SAGUNER, AM; S GANAHL; Andrea KRAUS; SH BALDINGER; D AKDIS et. al.

Základní údaje

Originální název

Electrocardiographic features of disease progression in arrhythmogenic right ventricular cardiomyopathy/dysplasia

Autoři

SAGUNER, AM; S GANAHL; Andrea KRAUS; SH BALDINGER; D AKDIS; AR SAGUNER; T WOLBER; LM HAEGELI; J STEFFEL; N KRASNIQI; TF LUSCHER; FC TANNER; C BRUNCKHORST a F DURU

Vydání

BMC Cardiovascular Disorders, London, Biomed Central Ltd, 2015, 1471-2261

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.916

DOI

http://dx.doi.org/10.1186/1471-2261-15

UT WoS

000348674300002

Klíčová slova anglicky

Arrhythmogenic Right Ventricular; Cardiomyopathy; Dysplasia; Electrocardiography; T wave inversion

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 1. 2016 23:11, Mgr. Andrea Kraus, M.Sc., Ph.D.

Anotace

V originále

Background: Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is considered a progressive cardiomyopathy. However, data on the clinical features of disease progression are limited. The aim of this study was to assess 12-lead surface electrocardiographic (ECG) changes during long-term follow-up, and to compare these findings with echocardiographic data in our large cohort of patients with ARVC/D. Methods: Baseline and follow-up ECGs of 111 patients from three tertiary care centers in Switzerland were systematically analyzed with digital calipers by two blinded observers, and correlated with findings from transthoracic echocardiography. Results: The median follow-up was 4 years (IQR 1.9-9.2 years). ECG progression was significant for epsilon waves (baseline 14% vs. follow-up 31%, p = 0.01) and QRS duration (111 ms vs. 114 ms, p = 0.04). Six patients with repolarization abnormalities according to the 2010 Task Force Criteria at baseline did not display these criteria at follow-up, whereas in all patients with epsilon waves at baseline these depolarization abnormalities also remained at follow-up. T wave inversions in inferior leads were common (36% of patients at baseline), and were significantly associated with major repolarization abnormalities (p = 0.02), extensive echocardiographic right ventricular involvement (p = 0.04), T wave inversions in lateral precordial leads (p = 0.05), and definite ARVC/D (p = 0.05). Conclusions: Our data supports the concept that ARVC/D is generally progressive, which can be detected by 12-lead surface ECG. Repolarization abnormalities may disappear during the course of the disease. Furthermore, the presence of T wave inversions in inferior leads is common in ARVC/D.

Citovat

SAGUNER, AM; S GANAHL; Andrea KRAUS; SH BALDINGER; D AKDIS; AR SAGUNER; T WOLBER; LM HAEGELI; J STEFFEL; N KRASNIQI; TF LUSCHER; FC TANNER; C BRUNCKHORST a F DURU. Electrocardiographic features of disease progression in arrhythmogenic right ventricular cardiomyopathy/dysplasia. BMC Cardiovascular Disorders. London: Biomed Central Ltd, 2015, roč. 15, 9 s. ISSN 1471-2261. Dostupné z: https://dx.doi.org/10.1186/1471-2261-15.

@article{1324042,
   author = {Saguner, AM and Ganahl, S and Kraus, Andrea and Baldinger, SH and Akdis, D and Saguner, AR and Wolber, T and Haegeli, LM and Steffel, J and Krasniqi, N and Luscher, TF and Tanner, FC and Brunckhorst, C and Duru, F},
   article_location = {London},
   doi = {http://dx.doi.org/10.1186/1471-2261-15},
   keywords = {Arrhythmogenic Right Ventricular; Cardiomyopathy; Dysplasia; Electrocardiography; T wave inversion},
   language = {eng},
   issn = {1471-2261},
   journal = {BMC Cardiovascular Disorders},
   title = {Electrocardiographic features of disease progression in arrhythmogenic right ventricular cardiomyopathy/dysplasia},
   url = {http://dx.doi.org/10.1186/1471-2261-15},
   volume = {15},
   year = {2015}
}

TY  - JOUR
ID  - 1324042
AU  - Saguner, AM - Ganahl, S - Kraus, Andrea - Baldinger, SH - Akdis, D - Saguner, AR - Wolber, T - Haegeli, LM - Steffel, J - Krasniqi, N - Luscher, TF - Tanner, FC - Brunckhorst, C - Duru, F
PY  - 2015
TI  - Electrocardiographic features of disease progression in arrhythmogenic right ventricular cardiomyopathy/dysplasia
JF  - BMC Cardiovascular Disorders
VL  - 15
PB  - Biomed Central Ltd
SN  - 14712261
KW  - Arrhythmogenic Right Ventricular
KW  - Cardiomyopathy
KW  - Dysplasia
KW  - Electrocardiography
KW  - T wave inversion
UR  - http://dx.doi.org/10.1186/1471-2261-15
L2  - http://dx.doi.org/10.1186/1471-2261-15
N2  - Background: Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is considered a progressive cardiomyopathy. However, data on the clinical features of disease progression are limited. The aim of this study was to assess 12-lead surface electrocardiographic (ECG) changes during long-term follow-up, and to compare these findings with echocardiographic data in our large cohort of patients with ARVC/D. Methods: Baseline and follow-up ECGs of 111 patients from three tertiary care centers in Switzerland were systematically analyzed with digital calipers by two blinded observers, and correlated with findings from transthoracic echocardiography. Results: The median follow-up was 4 years (IQR 1.9-9.2 years). ECG progression was significant for epsilon waves (baseline 14% vs. follow-up 31%, p = 0.01) and QRS duration (111 ms vs. 114 ms, p = 0.04). Six patients with repolarization abnormalities according to the 2010 Task Force Criteria at baseline did not display these criteria at follow-up, whereas in all patients with epsilon waves at baseline these depolarization abnormalities also remained at follow-up. T wave inversions in inferior leads were common (36% of patients at baseline), and were significantly associated with major repolarization abnormalities (p = 0.02), extensive echocardiographic right ventricular involvement (p = 0.04), T wave inversions in lateral precordial leads (p = 0.05), and definite ARVC/D (p = 0.05). Conclusions: Our data supports the concept that ARVC/D is generally progressive, which can be detected by 12-lead surface ECG. Repolarization abnormalities may disappear during the course of the disease. Furthermore, the presence of T wave inversions in inferior leads is common in ARVC/D.
ER  -

SAGUNER, AM; S GANAHL; Andrea KRAUS; SH BALDINGER; D AKDIS; AR SAGUNER; T WOLBER; LM HAEGELI; J STEFFEL; N KRASNIQI; TF LUSCHER; FC TANNER; C BRUNCKHORST a F DURU. Electrocardiographic features of disease progression in arrhythmogenic right ventricular cardiomyopathy/dysplasia. \textit{BMC Cardiovascular Disorders}. London: Biomed Central Ltd, 2015, roč.~15, 9 s. ISSN~1471-2261. Dostupné z: https://dx.doi.org/10.1186/1471-2261-15.

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