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@article{1324042,
author = {Saguner, AM and Ganahl, S and Kraus, Andrea and Baldinger, SH and Akdis, D and Saguner, AR and Wolber, T and Haegeli, LM and Steffel, J and Krasniqi, N and Luscher, TF and Tanner, FC and Brunckhorst, C and Duru, F},
article_location = {London},
doi = {http://dx.doi.org/10.1186/1471-2261-15},
keywords = {Arrhythmogenic Right Ventricular; Cardiomyopathy; Dysplasia; Electrocardiography; T wave inversion},
language = {eng},
issn = {1471-2261},
journal = {BMC Cardiovascular Disorders},
title = {Electrocardiographic features of disease progression in arrhythmogenic right ventricular cardiomyopathy/dysplasia},
url = {http://dx.doi.org/10.1186/1471-2261-15},
volume = {15},
year = {2015}
}
TY - JOUR
ID - 1324042
AU - Saguner, AM - Ganahl, S - Kraus, Andrea - Baldinger, SH - Akdis, D - Saguner, AR - Wolber, T - Haegeli, LM - Steffel, J - Krasniqi, N - Luscher, TF - Tanner, FC - Brunckhorst, C - Duru, F
PY - 2015
TI - Electrocardiographic features of disease progression in arrhythmogenic right ventricular cardiomyopathy/dysplasia
JF - BMC Cardiovascular Disorders
VL - 15
PB - Biomed Central Ltd
SN - 14712261
KW - Arrhythmogenic Right Ventricular
KW - Cardiomyopathy
KW - Dysplasia
KW - Electrocardiography
KW - T wave inversion
UR - http://dx.doi.org/10.1186/1471-2261-15
L2 - http://dx.doi.org/10.1186/1471-2261-15
N2 - Background: Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is considered a progressive cardiomyopathy. However, data on the clinical features of disease progression are limited. The aim of this study was to assess 12-lead surface electrocardiographic (ECG) changes during long-term follow-up, and to compare these findings with echocardiographic data in our large cohort of patients with ARVC/D. Methods: Baseline and follow-up ECGs of 111 patients from three tertiary care centers in Switzerland were systematically analyzed with digital calipers by two blinded observers, and correlated with findings from transthoracic echocardiography. Results: The median follow-up was 4 years (IQR 1.9-9.2 years). ECG progression was significant for epsilon waves (baseline 14% vs. follow-up 31%, p = 0.01) and QRS duration (111 ms vs. 114 ms, p = 0.04). Six patients with repolarization abnormalities according to the 2010 Task Force Criteria at baseline did not display these criteria at follow-up, whereas in all patients with epsilon waves at baseline these depolarization abnormalities also remained at follow-up. T wave inversions in inferior leads were common (36% of patients at baseline), and were significantly associated with major repolarization abnormalities (p = 0.02), extensive echocardiographic right ventricular involvement (p = 0.04), T wave inversions in lateral precordial leads (p = 0.05), and definite ARVC/D (p = 0.05). Conclusions: Our data supports the concept that ARVC/D is generally progressive, which can be detected by 12-lead surface ECG. Repolarization abnormalities may disappear during the course of the disease. Furthermore, the presence of T wave inversions in inferior leads is common in ARVC/D.
ER -
SAGUNER, AM, S GANAHL, Andrea KRAUS, SH BALDINGER, D AKDIS, AR SAGUNER, T WOLBER, LM HAEGELI, J STEFFEL, N KRASNIQI, TF LUSCHER, FC TANNER, C BRUNCKHORST a F DURU. Electrocardiographic features of disease progression in arrhythmogenic right ventricular cardiomyopathy/dysplasia. \textit{BMC Cardiovascular Disorders}. London: Biomed Central Ltd, roč.~15, 9 s. ISSN~1471-2261. doi:10.1186/1471-2261-15. 2015.
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