RÁJOVÁ, Jana, Roman PANTŮČEK, Petr PETRÁŠ, Ivana VARBANOVOVÁ, Ivana MAŠLAŇOVÁ a Jiří BENEŠ. Necrotizing pneumonia due to clonally diverse Staphylococcus aureus strains producing Panton-Valentine leukocidin: the Czech experience. Epidemiology & Infection. Cambridge University Press, 2016, roč. 144, č. 3, s. 507-515. ISSN 0950-2688. Dostupné z: https://dx.doi.org/10.1017/S0950268815001521. |
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@article{1324220, author = {Rájová, Jana and Pantůček, Roman and Petráš, Petr and Varbanovová, Ivana and Mašlaňová, Ivana and Beneš, Jiří}, article_number = {3}, doi = {http://dx.doi.org/10.1017/S0950268815001521}, keywords = {Community-acquired pneumonia; necrotizing pneumonia; Panton–Valentine leukocidin; septic shock; Staphylococcus aureus}, language = {eng}, issn = {0950-2688}, journal = {Epidemiology & Infection}, title = {Necrotizing pneumonia due to clonally diverse Staphylococcus aureus strains producing Panton-Valentine leukocidin: the Czech experience}, url = {http://dx.doi.org/10.1017/S0950268815001521}, volume = {144}, year = {2016} }
TY - JOUR ID - 1324220 AU - Rájová, Jana - Pantůček, Roman - Petráš, Petr - Varbanovová, Ivana - Mašlaňová, Ivana - Beneš, Jiří PY - 2016 TI - Necrotizing pneumonia due to clonally diverse Staphylococcus aureus strains producing Panton-Valentine leukocidin: the Czech experience JF - Epidemiology & Infection VL - 144 IS - 3 SP - 507-515 EP - 507-515 PB - Cambridge University Press SN - 09502688 KW - Community-acquired pneumonia KW - necrotizing pneumonia KW - Panton–Valentine leukocidin KW - septic shock KW - Staphylococcus aureus UR - http://dx.doi.org/10.1017/S0950268815001521 L2 - http://dx.doi.org/10.1017/S0950268815001521 N2 - A prospective study (2007–2013) was undertaken to investigate clinical features and prognostic factors of necrotizing pneumonia caused by Staphylococcus aureus producing Panton–Valentine leukocidin (PVL) in the Czech Republic. Twelve cases of necrotizing pneumonia were detected in 12 patients (median age 25 years) without severe underlying disease. Eight cases occurred in December and January and the accumulation of cases in the winter months preceding the influenza season was statistically significant (P < 0·001). The course of pneumonia was very rapid, leading to early sepsis and/or septic shock in all but one patient. Seven patients died and mortality was fourfold higher in those patients presenting with primary pneumonia than with pneumonia complicating other staphylococcal/pyogenic infection elsewhere in the body. The S. aureus isolates displayed considerable genetic variability and were assigned to five lineages CC8 (n = 3), CC15 (n = 2), CC30 (n = 2), CC80 (n = 1), and CC121 (n = 3) and one was a singleton of ST154 (n = 1), all were reported to be associated with community-acquired infection. Four strains were methicillin resistant. The high case-fatality rate can only be reduced by improving the speed of diagnosis and a rapid test to detect S. aureus in the airways is needed. ER -
RÁJOVÁ, Jana, Roman PANTŮČEK, Petr PETRÁŠ, Ivana VARBANOVOVÁ, Ivana MAŠLAŇOVÁ a Jiří BENEŠ. Necrotizing pneumonia due to clonally diverse Staphylococcus aureus strains producing Panton-Valentine leukocidin: the Czech experience. \textit{Epidemiology \&{} Infection}. Cambridge University Press, 2016, roč.~144, č.~3, s.~507-515. ISSN~0950-2688. Dostupné z: https://dx.doi.org/10.1017/S0950268815001521.
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