| DOVRTĚLOVÁ, Gabriela, Kristýna NOSKOVÁ, Jan JUŘICA, Miroslav TURJAP a Ondřej ZENDULKA. Can Bioactive Compounds of Crocus sativus L. Influence the Metabolic Activity of Selected CYP Enzymes in the Rat? Physiological Research. Praha: Fyziologický ústav AV ČR, 2015, roč. 64, Suppl. 4, s. "S453"-"S458", 6 s. ISSN 0862-8408. |
Další formáty:
BibTeX
LaTeX
RIS
@article{1331165,
author = {Dovrtělová, Gabriela and Nosková, Kristýna and Juřica, Jan and Turjap, Miroslav and Zendulka, Ondřej},
article_location = {Praha},
article_number = {Suppl. 4},
keywords = {crocin; safranal; CYP; rat liver microsomes},
language = {eng},
issn = {0862-8408},
journal = {Physiological Research},
title = {Can Bioactive Compounds of Crocus sativus L. Influence the Metabolic Activity of Selected CYP Enzymes in the Rat?},
url = {http://www.biomed.cas.cz/physiolres/2015/S4_15.htm},
volume = {64},
year = {2015}
}
TY - JOUR
ID - 1331165
AU - Dovrtělová, Gabriela - Nosková, Kristýna - Juřica, Jan - Turjap, Miroslav - Zendulka, Ondřej
PY - 2015
TI - Can Bioactive Compounds of Crocus sativus L. Influence the Metabolic Activity of Selected CYP Enzymes in the Rat?
JF - Physiological Research
VL - 64
IS - Suppl. 4
SP - "S453"-"S458"
EP - "S453"-"S458"
PB - Fyziologický ústav AV ČR
SN - 08628408
KW - crocin
KW - safranal
KW - CYP
KW - rat liver microsomes
UR - http://www.biomed.cas.cz/physiolres/2015/S4_15.htm
N2 - The aim of the present study was to determine, whether systemic administration of safranal and crocin can influence the metabolic activity of CYP3A, CYP2C11, CYP2B, and CYP2A in rat liver microsomes (RLM). Our results demonstrate the ability of safranal and crocin to increase the total protein content and to change the metabolic activity of several CYP enzymes assessed as CYP specific hydroxylations of testosterone in RLM. Crocin significantly decreased the metabolic activity of all selected CYP enzymes, while safranal significantly increased the metabolic activity of CYP2B, CYP2C11 and CYP3A enzymes.
ER -
DOVRTĚLOVÁ, Gabriela, Kristýna NOSKOVÁ, Jan JUŘICA, Miroslav TURJAP a Ondřej ZENDULKA. Can Bioactive Compounds of Crocus sativus L. Influence the Metabolic Activity of Selected CYP Enzymes in the Rat? \textit{Physiological Research}. Praha: Fyziologický ústav AV ČR, 2015, roč.~64, Suppl. 4, s.~''S453''-''S458'', 6 s. ISSN~0862-8408.
|
