| HLAVÁČOVÁ, Miroslava, Jaromír GUMULEC, Tibor STRAČINA, Michaela FOJTŮ, Martina RAUDENSKÁ, Michal MASAŘÍK, Marie NOVÁKOVÁ a Hana PAULOVÁ. Different Doxorubicin Formulations Affect Plasma 4-Hydroxy-2-Nonenal and Gene Expression of Aldehyde Dehydrogenase 3A1 and Thioredoxin Reductase 2 in Rat. Physiological Research. Praha: Fyziologický ústav AV ČR, roč. 64, Suppl. 5, s. "S653"-"S660", 8 s. ISSN 0862-8408. 2015. |
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@article{1332505,
author = {Hlaváčová, Miroslava and Gumulec, Jaromír and Stračina, Tibor and Fojtů, Michaela and Raudenská, Martina and Masařík, Michal and Nováková, Marie and Paulová, Hana},
article_location = {Praha},
article_number = {Suppl. 5},
keywords = {Doxorubicin; Drug nanotransporters; Oxidative stress; 4-hydroxy-2-nonenal; Thioredoxin reductase 2; Aldehyde dehydrogenase 3A1},
language = {eng},
issn = {0862-8408},
journal = {Physiological Research},
title = {Different Doxorubicin Formulations Affect Plasma 4-Hydroxy-2-Nonenal and Gene Expression of Aldehyde Dehydrogenase 3A1 and Thioredoxin Reductase 2 in Rat},
volume = {64},
year = {2015}
}
TY - JOUR
ID - 1332505
AU - Hlaváčová, Miroslava - Gumulec, Jaromír - Stračina, Tibor - Fojtů, Michaela - Raudenská, Martina - Masařík, Michal - Nováková, Marie - Paulová, Hana
PY - 2015
TI - Different Doxorubicin Formulations Affect Plasma 4-Hydroxy-2-Nonenal and Gene Expression of Aldehyde Dehydrogenase 3A1 and Thioredoxin Reductase 2 in Rat
JF - Physiological Research
VL - 64
IS - Suppl. 5
SP - "S653"-"S660"
EP - "S653"-"S660"
PB - Fyziologický ústav AV ČR
SN - 08628408
KW - Doxorubicin
KW - Drug nanotransporters
KW - Oxidative stress
KW - 4-hydroxy-2-nonenal
KW - Thioredoxin reductase 2
KW - Aldehyde dehydrogenase 3A1
N2 - Increased oxidative stress is indisputably an important mechanism of doxorubicin side effects, especially its cardiotoxicity. To prevent Impairment of non-tumnrous tissue and to Improve the specificity in targeting the tumor tissue, new drug nanotransporters are developed. In many cases predinical therapeutic advantage has been shown when compared with the administration of conventional drug solution. Three forms of doxorubicin - conventional (DOX), encapsulated In liposomes (lipoDOX) and in apoferritin (apoDQX) were applied to Wistar rats. After 24 h exposition, the plasma level of 4-hydroxy-2-nonenal (4-HNE) as a marker of lipoperoxidalion and tissue gene expression of thioredoxln reductase 2 (TXNRDZ} and aldehyde dehydrogenase 3A1 (ALDH3AI) as an important part of antioxidative system were determined. Only conventional DOX significantly increases the level of 4-HNE; encapsulated forms on the other hand show significant decrease in plasma levels of 4-HNE In comparison with DOX. They also cause significant decrease In gene expression of ALDH3A1 and TXNRD2 In liver as a main detoxification organ, and a mild Influence on the expression of these enzymes in left heart ventride as a potential target of toxiclty. Thus, 4-HNE seems to be a good potential biomarker of oxidative stress induced by various forms of doxorubicin.
ER -
HLAVÁČOVÁ, Miroslava, Jaromír GUMULEC, Tibor STRAČINA, Michaela FOJTŮ, Martina RAUDENSKÁ, Michal MASAŘÍK, Marie NOVÁKOVÁ a Hana PAULOVÁ. Different Doxorubicin Formulations Affect Plasma 4-Hydroxy-2-Nonenal and Gene Expression of Aldehyde Dehydrogenase 3A1 and Thioredoxin Reductase 2 in Rat. \textit{Physiological Research}. Praha: Fyziologický ústav AV ČR, roč.~64, Suppl. 5, s.~''S653''-''S660'', 8 s. ISSN~0862-8408. 2015.
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