Impaired response of regulator of G alpha q signaling-2 mRNA to
angiotensin II and hypertensive renal injury in Dahl
salt-sensitive rats

J 2016

Impaired response of regulator of G alpha q signaling-2 mRNA to angiotensin II and hypertensive renal injury in Dahl salt-sensitive rats

WU, Yaqiong; Hidenori TAKAHASHI; Etsu SUZUKI; Peter KRUŽLIAK; Miroslav SOUČEK et al.

Základní údaje

Originální název

Impaired response of regulator of G alpha q signaling-2 mRNA to angiotensin II and hypertensive renal injury in Dahl salt-sensitive rats

Autoři

WU, Yaqiong; Hidenori TAKAHASHI; Etsu SUZUKI; Peter KRUŽLIAK; Miroslav SOUČEK a Yoshio UEHARA

Vydání

Hypertension Research, London, Nature Publishing Group, 2016, 0916-9636

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.581

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/16:00089334

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

angiotensin; Dahl rat; kidney damage; RGS2; salt hypertension

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 3. 8. 2016 15:41, Soňa Böhmová

Anotace

V originále

Dahl salt-sensitive (Dahl S) rats are prone to salt-dependent hypertension with severe organ damage, including stroke, cardiac failure and renal insufficiency. The mechanism for this susceptibility to kidney injury has not been elucidated. The present study proposed that an upregulation of intracellular signaling of angiotensin II (Ang-II) is responsible for the susceptibility to hypertensive kidney injury in Dahl S rats. Spontaneously hypertensive rats exhibited higher systolic blood pressure (SBP) and lower kidney damage than Dahl S rats fed a high-salt diet for 2 weeks. Ang-II infusion for 4 weeks significantly increased SBP in Dahl S and Dahl salt-resistant (Dahl R) rats fed a low-salt diet. The increase in SBP in Dahl S rats was associated with significant kidney injury with greater glomerular sclerosis (Po0.001). The expression of regulatory protein of Gaq signaling-2 (RGS2) mRNA in the aortic walls in response to Ang-II infusion was lower in Dahl S than Dahl R rats (Po0.05). Ang-II significantly increased RGS2 mRNA in the aorta in Dahl R rats, but the response was apparently blunted in Dahl S rats. These results suggest that Dahl S rats exhibit a blunted RGS2 response to Ang-II, and this blunted response may be partially responsible for the susceptibility to renal injury in Dahl S rats.

Citovat

WU, Yaqiong; Hidenori TAKAHASHI; Etsu SUZUKI; Peter KRUŽLIAK; Miroslav SOUČEK a Yoshio UEHARA. Impaired response of regulator of G alpha q signaling-2 mRNA to angiotensin II and hypertensive renal injury in Dahl salt-sensitive rats. Hypertension Research. London: Nature Publishing Group, 2016, roč. 39, č. 4, s. 210-216. ISSN 0916-9636. Dostupné z: https://doi.org/10.1038/hr.2015.132.

@article{1333987,
   author = {Wu, Yaqiong and Takahashi, Hidenori and Suzuki, Etsu and Kružliak, Peter and Souček, Miroslav and Uehara, Yoshio},
   article_location = {London},
   article_number = {4},
   doi = {https://doi.org/10.1038/hr.2015.132},
   keywords = {angiotensin; Dahl rat; kidney damage; RGS2; salt hypertension},
   language = {eng},
   issn = {0916-9636},
   journal = {Hypertension Research},
   title = {Impaired response of regulator of G alpha q signaling-2 mRNA to angiotensin II and hypertensive renal injury in Dahl salt-sensitive rats},
   volume = {39},
   year = {2016}
}

TY  - JOUR
ID  - 1333987
AU  - Wu, Yaqiong - Takahashi, Hidenori - Suzuki, Etsu - Kružliak, Peter - Souček, Miroslav - Uehara, Yoshio
PY  - 2016
TI  - Impaired response of regulator of G alpha q signaling-2 mRNA to angiotensin II and hypertensive renal injury in Dahl salt-sensitive rats
JF  - Hypertension Research
VL  - 39
IS  - 4
SP  - 210-216
EP  - 210-216
PB  - Nature Publishing Group
SN  - 09169636
KW  - angiotensin
KW  - Dahl rat
KW  - kidney damage
KW  - RGS2
KW  - salt hypertension
N2  - Dahl salt-sensitive (Dahl S) rats are prone to salt-dependent hypertension with severe organ damage, including stroke, cardiac failure and renal insufficiency. The mechanism for this susceptibility to kidney injury has not been elucidated. The present study proposed that an upregulation of intracellular signaling of angiotensin II (Ang-II) is responsible for the susceptibility to hypertensive kidney injury in Dahl S rats. Spontaneously hypertensive rats exhibited higher systolic blood pressure (SBP) and lower kidney damage than Dahl S rats fed a high-salt diet for 2 weeks. Ang-II infusion for 4 weeks significantly increased SBP in Dahl S and Dahl salt-resistant (Dahl R) rats fed a low-salt diet. The increase in SBP in Dahl S rats was associated with significant kidney injury with greater glomerular sclerosis (Po0.001). The expression of regulatory protein of Gaq signaling-2 (RGS2) mRNA in the aortic walls in response to Ang-II infusion was lower in Dahl S than Dahl R rats (Po0.05). Ang-II significantly increased RGS2 mRNA in the aorta in Dahl R rats, but the response was apparently blunted in Dahl S rats. These results suggest that Dahl S rats exhibit a blunted RGS2 response to Ang-II, and this blunted response may be partially responsible for the susceptibility to renal injury in Dahl S rats.
ER  -

WU, Yaqiong; Hidenori TAKAHASHI; Etsu SUZUKI; Peter KRUŽLIAK; Miroslav SOUČEK a Yoshio UEHARA. Impaired response of regulator of G alpha q signaling-2 mRNA to angiotensin II and hypertensive renal injury in Dahl salt-sensitive rats. \textit{Hypertension Research}. London: Nature Publishing Group, 2016, roč.~39, č.~4, s.~210-216. ISSN~0916-9636. Dostupné z: https://doi.org/10.1038/hr.2015.132.

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