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@inproceedings{1334716,
author = {Janoušek, Oto and Ronzhina, Marina and Hejč, Jakub and Olejníčková, Veronika and Stračina, Tibor and Fialová, Kateřina and Nováková, Marie and Provazní, Ivo and Kolářová, Jana},
address = {Washington},
booktitle = {Computing in Cardiology 2015},
editor = {Alan Murray},
keywords = {di-4-ANEPPS;Voltage-Sensitive Dye},
howpublished = {tištěná verze "print"},
language = {eng},
location = {Washington},
pages = {1049-1052},
publisher = {IEEE Computer Society},
title = {The Effect of Voltage-Sensitive Dye di-4-ANEPPS on Heart Rate Variability in Langendorff-Perfused Isolated Rabbit Heart},
year = {2015}
}
TY - JOUR
ID - 1334716
AU - Janoušek, Oto - Ronzhina, Marina - Hejč, Jakub - Olejníčková, Veronika - Stračina, Tibor - Fialová, Kateřina - Nováková, Marie - Provazní, Ivo - Kolářová, Jana
PY - 2015
TI - The Effect of Voltage-Sensitive Dye di-4-ANEPPS on Heart Rate Variability in Langendorff-Perfused Isolated Rabbit Heart
PB - IEEE Computer Society
CY - Washington
KW - di-4-ANEPPS;Voltage-Sensitive Dye
N2 - Optical mapping of heart electrical activity in Langendorff-perfused isolated hearts is based on voltagesensitive dyes, of which the most commonly used one is di-4-ANEPPS. Prolongation of action potential duration by di-4-ANEPPS was reported in isolated cells; however, this phenomenon was not observed in the whole heart model. In order to search for other adverse phenomena of di- 4-ANEPPS use, its effect on heart rate variability (HRV) was investigated during staining and washout periods in five New Zealand White rabbit isolated hearts. Time domain, frequency domain and non-linear HRV parameters (21 in total) revealed that there are no significant changes between control, staining and washout periods. Voltage-sensitive dye di-4-ANEPPS does not affect HRV when applied into the isolated heart coronary system. It can be concluded that di-4-ANEPPS may be safely used in studies combining optical mapping and HRV analysis
ER -
JANOUŠEK, Oto, Marina RONZHINA, Jakub HEJČ, Veronika OLEJNÍČKOVÁ, Tibor STRAČINA, Kateřina FIALOVÁ, Marie NOVÁKOVÁ, Ivo PROVAZNÍ a Jana KOLÁŘOVÁ. The Effect of Voltage-Sensitive Dye di-4-ANEPPS on Heart Rate Variability in Langendorff-Perfused Isolated Rabbit Heart. In Alan Murray. \textit{Computing in Cardiology 2015}. Washington: IEEE Computer Society, 2015, s.~1049-1052. ISSN~2325-8861.
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