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@article{1336048,
author = {Javůrková, Barbora and Javůrek, Jakub and Adamovský, Ondřej and Hilscherová, Klára},
article_location = {OXFORD (ENGLAND)},
article_number = {AUGUST},
doi = {http://dx.doi.org/10.1016/j.envint.2015.03.019},
keywords = {Phytoestrogen; Mycoestrogen; Estrogenicity; Sterol; Phytosterols; Flavonoids; Surface waters; Estrogenic equivalent; Relative potency},
language = {eng},
issn = {0160-4120},
journal = {Environment International},
title = {Phytoestrogens and mycoestrogens in surface waters - Their sources, occurrence, and potential contribution to estrogenic activity},
url = {http://www.sciencedirect.com/science/article/pii/S0160412015000859},
volume = {81},
year = {2015}
}
TY - JOUR
ID - 1336048
AU - Javůrková, Barbora - Javůrek, Jakub - Adamovský, Ondřej - Hilscherová, Klára
PY - 2015
TI - Phytoestrogens and mycoestrogens in surface waters - Their sources, occurrence, and potential contribution to estrogenic activity
JF - Environment International
VL - 81
IS - AUGUST
SP - 26-44
EP - 26-44
PB - Pergamon Press
SN - 01604120
KW - Phytoestrogen
KW - Mycoestrogen
KW - Estrogenicity
KW - Sterol
KW - Phytosterols
KW - Flavonoids
KW - Surface waters
KW - Estrogenic equivalent
KW - Relative potency
UR - http://www.sciencedirect.com/science/article/pii/S0160412015000859
L2 - http://www.sciencedirect.com/science/article/pii/S0160412015000859
N2 - This review discusses the potential contribution of phytoestrogens and mycoestrogens to in vitro estrogenic activities occurring in surface waters and in vivo estrogenic effects in fish. Main types, sources, and pathways of entry into aquatic environment of these detected compounds were summarized. Reviewed concentrations of phyto/mycoestrogens in surface waters were mostly undetectable or in low ng/L ranges, but exceeded tens of mu g/L for the flavonoids biochanin A, daidzein and genistein at some sites. While a few phytosterols were reported to occur at relatively high concentrations in surface waters, information about their potencies in in vitro systems is very limited, and contradictory in some cases. The relative estrogenic activities of compounds (compared to standard estrogen 17 beta-estradiol) by various in vitro assays were included, and found to differ by orders of magnitude. These potencies were used to estimate total potential estrogenic activities based on chemical analyses of phyto/mycoestrogens. In vivo effective concentrations of waterborne phyto/mycoestrogens were available only for biochanin A, daidzein, formononetin, genistein, equol, sitosterol, and zearalenone. The lowest observable effect concentrations in vivo were reported for the mycoestrogen zearalenone. This compound and especially its metabolites also elicited the highest in vitro estrogenic potencies. Despite the limited information available, the review documents low contribution of phyto/mycoestrogens to estrogenic activity in vast majority of surface waters, but significant contribution to in vitro responses and potentially also to in vivo effects in areas with high concentrations.
ER -
JAVŮRKOVÁ, Barbora, Jakub JAVŮREK, Ondřej ADAMOVSKÝ a Klára HILSCHEROVÁ. Phytoestrogens and mycoestrogens in surface waters - Their sources, occurrence, and potential contribution to estrogenic activity. \textit{Environment International}. OXFORD (ENGLAND): Pergamon Press, 2015, roč.~81, AUGUST, s.~26-44. ISSN~0160-4120. Dostupné z: https://dx.doi.org/10.1016/j.envint.2015.03.019.
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