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@article{1336948,
author = {Neale, Peta A. and AitandAissa, Selim and Brack, Werner and Creusot, Nicolas and Denison, Michael S. and Deutschmann, Bjoern and Hilscherová, Klára and Hollert, Henner and Krauss, Martin and Novák, Jiří and Schulze, Tobias and Seiler, ThomasandBenjamin and Serra, Helene and Shao, Ying and Escher, Beate I.},
article_location = {WASHINGTON, DC (USA)},
article_number = {24},
doi = {http://dx.doi.org/10.1021/acs.est.5b04083},
keywords = {ARYL-HYDROCARBON RECEPTOR; OXIDATIVE STRESS-RESPONSE; TREATMENT-PLANT EFFLUENTS; QUALITY TRIGGER VALUES; PREGNANE X RECEPTOR; WASTE-WATER; CHEMICAL-ANALYSIS; RISK-ASSESSMENT; CONCEPTUAL-FRAMEWORK; THYROID-HORMONE},
language = {eng},
issn = {0013-936X},
journal = {ENVIRONMENTAL SCIENCE & TECHNOLOGY},
title = {Linking in Vitro Effects and Detected Organic Micropollutants in Surface Water Using Mixture-Toxicity Modeling},
url = {http://pubs.acs.org/doi/10.1021/acs.est.5b04083},
volume = {49},
year = {2015}
}
TY - JOUR
ID - 1336948
AU - Neale, Peta A. - Ait-Aissa, Selim - Brack, Werner - Creusot, Nicolas - Denison, Michael S. - Deutschmann, Bjoern - Hilscherová, Klára - Hollert, Henner - Krauss, Martin - Novák, Jiří - Schulze, Tobias - Seiler, Thomas-Benjamin - Serra, Helene - Shao, Ying - Escher, Beate I.
PY - 2015
TI - Linking in Vitro Effects and Detected Organic Micropollutants in Surface Water Using Mixture-Toxicity Modeling
JF - ENVIRONMENTAL SCIENCE & TECHNOLOGY
VL - 49
IS - 24
SP - 14614-14624
EP - 14614-14624
PB - AMER CHEMICAL SOC
SN - 0013936X
KW - ARYL-HYDROCARBON RECEPTOR
KW - OXIDATIVE STRESS-RESPONSE
KW - TREATMENT-PLANT EFFLUENTS
KW - QUALITY TRIGGER VALUES
KW - PREGNANE X RECEPTOR
KW - WASTE-WATER
KW - CHEMICAL-ANALYSIS
KW - RISK-ASSESSMENT
KW - CONCEPTUAL-FRAMEWORK
KW - THYROID-HORMONE
UR - http://pubs.acs.org/doi/10.1021/acs.est.5b04083
L2 - http://pubs.acs.org/doi/10.1021/acs.est.5b04083
N2 - Surface water can contain countless organic micropollutants, and targeted chemical analysis alone may only detect a small fraction of the chemicals present. Consequently, bioanalytical tools can be applied complementary to chemical analysis to detect the effects of complex chemical mixtures. In this study, bioassays indicative of activation of the aryl hydrocarbon receptor (AhR), activation of the pregnane X receptor (PXR), activation of the estrogen receptor (ER), adaptive stress responses to oxidative stress (Nrf2), genotoxicity (p53) and inflammation (NF-kappa B) and the fish embryo toxicity test were applied along with chemical analysis to water extracts from the Danube River. Mixture-toxicity modeling was applied to determine the contribution of detected chemicals to the biological effect. Effect concentrations for between 0 to 13 detected chemicals could be found in the literature for the different bioassays. Detected chemicals explained less than 0.2% of the biological effect in the PXR activation, adaptive stress response, and fish embryo toxicity assays, while five chemicals explained up to 80% of ER activation, and three chemicals explained up to 71% of AhR activation. This study highlights the importance of fingerprinting the effects of detected chemicals.
ER -
NEALE, Peta A., Selim AIT-AISSA, Werner BRACK, Nicolas CREUSOT, Michael S. DENISON, Bjoern DEUTSCHMANN, Klára HILSCHEROVÁ, Henner HOLLERT, Martin KRAUSS, Jiří NOVÁK, Tobias SCHULZE, Thomas-Benjamin SEILER, Helene SERRA, Ying SHAO a Beate I. ESCHER. Linking in Vitro Effects and Detected Organic Micropollutants in Surface Water Using Mixture-Toxicity Modeling. \textit{ENVIRONMENTAL SCIENCE \&{}amp; TECHNOLOGY}. WASHINGTON, DC (USA): AMER CHEMICAL SOC, 2015, roč.~49, č.~24, s.~14614-14624. ISSN~0013-936X. Dostupné z: https://dx.doi.org/10.1021/acs.est.5b04083.
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