Primary Hyperparathyroidism, with a Focus on Management of the
Normocalcemic Form. To Treat or not to Treat?

J 2016

Primary Hyperparathyroidism, with a Focus on Management of the Normocalcemic Form. To Treat or not to Treat?

ŠIPROVÁ, Helena, Zdeněk FRYŠÁK a Miroslav SOUČEK

Základní údaje

Originální název

Primary Hyperparathyroidism, with a Focus on Management of the Normocalcemic Form. To Treat or not to Treat?

Autoři

ŠIPROVÁ, Helena (203 Česká republika), Zdeněk FRYŠÁK (203 Česká republika) a Miroslav SOUČEK (203 Česká republika, garant, domácí)

Vydání

Endocrine Practice, Jacksonville, American Association of Clinical Endocrinology, 2016, 1530-891X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30202 Endocrinology and metabolism

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.347

Kód RIV

RIV/00216224:14110/16:00089442

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.4158/EP15704.OR

UT WoS

000377968700002

Klíčová slova anglicky

hyperparathyroidism; NCPHPT

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 8. 2016 14:54, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

OBJECTIVE: The aim of this study was to determine reasonable care for NCPHPT patients treated at the Endocrine Clinic. METHODS: The study is based on 218 outpatient cases of primary hyperparathyroidism (PHPT), 187 (86%) of whom were NCPHPT. Subjective complaints, biochemical tests, imaging and treatment outcome for NCPHPT patients were monitored and compared with the same parameters in patients with hypercalcemic hyperparathyroidism (HCPHPT). The number of patients with newly diagnosed NCPHPT who became hypercalcemic and the time period in which it happened were also recorded. RESULTS: Over 6 years of study, in total, 36/187 originally normocalcemic patients became hypercalcemic (19%); 24/36 within 2 years and 2/36 later than after 4 years. MIBI scintigraphy was performed in 103 normocalcemic patients (adenoma was detected in 5 cases) and in 46 hypercalcemic patients with pathologically elevated serum calcium levels of at the time of assesment (adenoma was detected in 32/46 cases). Surgery was performed in 33 patients, 11 of whom were originally normocalcemic (i.e. 6% of all 187 originally normocalcemic patients) and 22 were hypercalcemic from the outset (i.e. 71% of all 31 originally hypercalcemic patients). CONCLUSIONS: Some NCPHPT patients converted to hypercalcemic, mostly within 2 years but some after 4 years or later. Normocalcemic patients should be monitored on long-term basis as it is impossible to anticipate when and which normocalcemic patients will become hypercalcemic. Imaging is much less effective in normocalcemic than in hypercalcemic patients.

Citovat

ŠIPROVÁ, Helena, Zdeněk FRYŠÁK a Miroslav SOUČEK. Primary Hyperparathyroidism, with a Focus on Management of the Normocalcemic Form. To Treat or not to Treat? Endocrine Practice. Jacksonville: American Association of Clinical Endocrinology, 2016, roč. 22, č. 3, s. 294-301. ISSN 1530-891X. Dostupné z: https://dx.doi.org/10.4158/EP15704.OR.

@article{1337017,
   author = {Šiprová, Helena and Fryšák, Zdeněk and Souček, Miroslav},
   article_location = {Jacksonville},
   article_number = {3},
   doi = {http://dx.doi.org/10.4158/EP15704.OR},
   keywords = {hyperparathyroidism; NCPHPT},
   language = {eng},
   issn = {1530-891X},
   journal = {Endocrine Practice},
   title = {Primary Hyperparathyroidism, with a Focus on Management of the Normocalcemic Form. To Treat or not to Treat?},
   volume = {22},
   year = {2016}
}

TY  - JOUR
ID  - 1337017
AU  - Šiprová, Helena - Fryšák, Zdeněk - Souček, Miroslav
PY  - 2016
TI  - Primary Hyperparathyroidism, with a Focus on Management of the Normocalcemic Form. To Treat or not to Treat?
JF  - Endocrine Practice
VL  - 22
IS  - 3
SP  - 294-301
EP  - 294-301
PB  - American Association of Clinical Endocrinology
SN  - 1530891X
KW  - hyperparathyroidism
KW  - NCPHPT
N2  - OBJECTIVE: The aim of this study was to determine reasonable care for NCPHPT patients treated at the Endocrine Clinic. METHODS: The study is based on 218 outpatient cases of primary hyperparathyroidism (PHPT), 187 (86%) of whom were NCPHPT. Subjective complaints, biochemical tests, imaging and treatment outcome for NCPHPT patients were monitored and compared with the same parameters in patients with hypercalcemic hyperparathyroidism (HCPHPT). The number of patients with newly diagnosed NCPHPT who became hypercalcemic and the time period in which it happened were also recorded. RESULTS: Over 6 years of study, in total, 36/187 originally normocalcemic patients became hypercalcemic (19%); 24/36 within 2 years and 2/36 later than after 4 years. MIBI scintigraphy was performed in 103 normocalcemic patients (adenoma was detected in 5 cases) and in 46 hypercalcemic patients with pathologically elevated serum calcium levels of at the time of assesment (adenoma was detected in 32/46 cases). Surgery was performed in 33 patients, 11 of whom were originally normocalcemic (i.e. 6% of all 187 originally normocalcemic patients) and 22 were hypercalcemic from the outset (i.e. 71% of all 31 originally hypercalcemic patients). CONCLUSIONS: Some NCPHPT patients converted to hypercalcemic, mostly within 2 years but some after 4 years or later. Normocalcemic patients should be monitored on long-term basis as it is impossible to anticipate when and which normocalcemic patients will become hypercalcemic. Imaging is much less effective in normocalcemic than in hypercalcemic patients.
ER  -

ŠIPROVÁ, Helena, Zdeněk FRYŠÁK a Miroslav SOUČEK. Primary Hyperparathyroidism, with a Focus on Management of the Normocalcemic Form. To Treat or not to Treat? \textit{Endocrine Practice}. Jacksonville: American Association of Clinical Endocrinology, 2016, roč.~22, č.~3, s.~294-301. ISSN~1530-891X. Dostupné z: https://dx.doi.org/10.4158/EP15704.OR.

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