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@inproceedings{1338067,
author = {Subramaniam, Selvakumar and Ozdener, Mehmet Hakan and Sundaresan, Sinju and Šerý, Omar and Besnard, Philippe and Abumrad, Nada A and Khan, Naim Akhtar},
address = {Francie},
booktitle = {FUNDAMENTAL & CLINICAL PHARMACOLOGY},
doi = {http://dx.doi.org/10.1111/fcp.12064},
editor = {Pascal Bousquet and Emmanuel Oger},
keywords = {oral; fat; lipid; taste; bud},
howpublished = {tištěná verze "print"},
language = {eng},
location = {Francie},
pages = {87-88},
publisher = {WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA},
title = {CD36 and GPR120 differently mediate Ca2+ signaling in human taste bud cells},
year = {2014}
}
TY - JOUR
ID - 1338067
AU - Subramaniam, Selvakumar - Ozdener, Mehmet Hakan - Sundaresan, Sinju - Šerý, Omar - Besnard, Philippe - Abumrad, Nada A - Khan, Naim Akhtar
PY - 2014
TI - CD36 and GPR120 differently mediate Ca2+ signaling in human taste bud cells
PB - WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
CY - Francie
KW - oral
KW - fat
KW - lipid
KW - taste
KW - bud
N2 - High concentrations of linoleic acid induced Ca(2+) signaling via CD36 and GPR120 in human and mice TBC, as well as in STC-1 cells, and low concentrations induced Ca(2+) signaling via only CD36. Incubation of human and mice fungiform TBC with lineoleic acid down-regulated CD36 and up-regulated GPR120 in membrane lipid rafts. Obese mice had decreased spontaneous preference for fat. Fungiform TBC from obese mice had reduced Ca(2+) and serotonin responses, but increased release of glucagon-like peptide-1, along with reduced levels of CD36 and increased levels of GPR120 in lipid rafts. CONCLUSIONS: CD36 and GPR120 have nonoverlapping roles in TBC signaling during orogustatory perception of dietary lipids; these are differentially regulated by obesity.
ER -
SUBRAMANIAM, Selvakumar, Mehmet Hakan OZDENER, Sinju SUNDARESAN, Omar ŠERÝ, Philippe BESNARD, Nada A ABUMRAD a Naim Akhtar KHAN. CD36 and GPR120 differently mediate Ca2+ signaling in human taste bud cells. In Pascal Bousquet and Emmanuel Oger. \textit{FUNDAMENTAL \&{} CLINICAL PHARMACOLOGY}. Francie: WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2014, s.~87-88. ISSN~1472-8206. Dostupné z: https://dx.doi.org/10.1111/fcp.12064.
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