Orthostatic hypotension in diabetic patients-10-year follow-up
study

J 2016

Orthostatic hypotension in diabetic patients-10-year follow-up study

GASPAR, Ludovit; Peter KRUŽLIAK; Andrea KOMORNIKOVA; Zuzana CELECOVA; Boris KRAHULEC et al.

Základní údaje

Originální název

Orthostatic hypotension in diabetic patients-10-year follow-up study

Autoři

GASPAR, Ludovit; Peter KRUŽLIAK; Andrea KOMORNIKOVA; Zuzana CELECOVA; Boris KRAHULEC; David BALAZ; Peter SABAKA; Martin CAPRNDA; Marek KUCERA; Luis RODRIGO; Yoshio UEHARA a Andrej DUKAT

Vydání

Journal of Diabetes and its Complications, USA, Elsvier Science, 2016, 1056-8727

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30202 Endocrinology and metabolism

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.734

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/16:00089533

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Diabetes mellitus; Diabetic cardiovascular autonomic neuropathy; Orthostatic hypotension; Microvascular and macrovascular complications; Mortality

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 8. 2016 14:46, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Introduction: Cardiovascular autonomic neuropathy in diabetics is a common but often underestimated and underdiagnosed complication of diabetes mellitus. One of the most clinical apparent forms of cardiovascular autonomic neuropathy is orthostatic hypotension. Objectives: To retrospectively assess the association of the orthostatic hypotension (OH) with macrovascular and microvascular complications of diabetes mellitus and to determine its effect on mortality. Design and methods: We retrospectively analyzed 187 patients with diabetes mellitus (60 patients with diabetes type 1 and 127 patients with diabetes type 2). Patients were divided into groups according to presence or absence of OH and type of diabetes. Association of OH with macrovascular and microvascular complications was evaluated and the effect of OH on 10-year all-cause mortality was also assessed. Results: OH was present in 31.7% of patients with diabetes type 1 (DM1) and in 32.3% of patients with diabetes type 2 (DM2). OH was positively associated with the prevalence of myocardial infarction in DM1 (OR = 10.67) and with prevalence of stroke in DM2 (OR = 3.33). There was also a strong association of OH and the prevalence of peripheral artery disease in both DM1 (OR = 14.18) and DM2 (OR = 3.26). Patients with both types of diabetes and OH had significantly higher prevalence of nephropathy (DM1 OR = 8.68, DM2 OR = 324), retinopathy (DM1 OR = 8.09, DM2 OR = 4.08) and peripheral neuropathy (DM1 OR = 17.14, DM2 OR = 7.51) Overall 10 year mortality rate was higher in diabetic patients with OH. Conclusions: Presence of OH in diabetics is associated with higher prevalence of macrovascular and microvascular complications of diabetes mellitus and also with higher 10-year mortality.

Citovat

GASPAR, Ludovit; Peter KRUŽLIAK; Andrea KOMORNIKOVA; Zuzana CELECOVA; Boris KRAHULEC; David BALAZ; Peter SABAKA; Martin CAPRNDA; Marek KUCERA; Luis RODRIGO; Yoshio UEHARA a Andrej DUKAT. Orthostatic hypotension in diabetic patients-10-year follow-up study. Journal of Diabetes and its Complications. USA: Elsvier Science, 2016, roč. 30, č. 1, s. 67-71. ISSN 1056-8727. Dostupné z: https://doi.org/10.1016/j.jdiacomp.2015.08.020.

@article{1339267,
   author = {Gaspar, Ludovit and Kružliak, Peter and Komornikova, Andrea and Celecova, Zuzana and Krahulec, Boris and Balaz, David and Sabaka, Peter and Caprnda, Martin and Kucera, Marek and Rodrigo, Luis and Uehara, Yoshio and Dukat, Andrej},
   article_location = {USA},
   article_number = {1},
   doi = {https://doi.org/10.1016/j.jdiacomp.2015.08.020},
   keywords = {Diabetes mellitus; Diabetic cardiovascular autonomic neuropathy; Orthostatic hypotension; Microvascular and macrovascular complications; Mortality},
   language = {eng},
   issn = {1056-8727},
   journal = {Journal of Diabetes and its Complications},
   title = {Orthostatic hypotension in diabetic patients-10-year follow-up study},
   volume = {30},
   year = {2016}
}

TY  - JOUR
ID  - 1339267
AU  - Gaspar, Ludovit - Kružliak, Peter - Komornikova, Andrea - Celecova, Zuzana - Krahulec, Boris - Balaz, David - Sabaka, Peter - Caprnda, Martin - Kucera, Marek - Rodrigo, Luis - Uehara, Yoshio - Dukat, Andrej
PY  - 2016
TI  - Orthostatic hypotension in diabetic patients-10-year follow-up study
JF  - Journal of Diabetes and its Complications
VL  - 30
IS  - 1
SP  - 67-71
EP  - 67-71
PB  - Elsvier Science
SN  - 10568727
KW  - Diabetes mellitus
KW  - Diabetic cardiovascular autonomic neuropathy
KW  - Orthostatic hypotension
KW  - Microvascular and macrovascular complications
KW  - Mortality
N2  - Introduction: Cardiovascular autonomic neuropathy in diabetics is a common but often underestimated and underdiagnosed complication of diabetes mellitus. One of the most clinical apparent forms of cardiovascular autonomic neuropathy is orthostatic hypotension. Objectives: To retrospectively assess the association of the orthostatic hypotension (OH) with macrovascular and microvascular complications of diabetes mellitus and to determine its effect on mortality. Design and methods: We retrospectively analyzed 187 patients with diabetes mellitus (60 patients with diabetes type 1 and 127 patients with diabetes type 2). Patients were divided into groups according to presence or absence of OH and type of diabetes. Association of OH with macrovascular and microvascular complications was evaluated and the effect of OH on 10-year all-cause mortality was also assessed. Results: OH was present in 31.7% of patients with diabetes type 1 (DM1) and in 32.3% of patients with diabetes type 2 (DM2). OH was positively associated with the prevalence of myocardial infarction in DM1 (OR = 10.67) and with prevalence of stroke in DM2 (OR = 3.33). There was also a strong association of OH and the prevalence of peripheral artery disease in both DM1 (OR = 14.18) and DM2 (OR = 3.26). Patients with both types of diabetes and OH had significantly higher prevalence of nephropathy (DM1 OR = 8.68, DM2 OR = 324), retinopathy (DM1 OR = 8.09, DM2 OR = 4.08) and peripheral neuropathy (DM1 OR = 17.14, DM2 OR = 7.51) Overall 10 year mortality rate was higher in diabetic patients with OH. Conclusions: Presence of OH in diabetics is associated with higher prevalence of macrovascular and microvascular complications of diabetes mellitus and also with higher 10-year mortality.
ER  -

GASPAR, Ludovit; Peter KRUŽLIAK; Andrea KOMORNIKOVA; Zuzana CELECOVA; Boris KRAHULEC; David BALAZ; Peter SABAKA; Martin CAPRNDA; Marek KUCERA; Luis RODRIGO; Yoshio UEHARA a Andrej DUKAT. Orthostatic hypotension in diabetic patients-10-year follow-up study. \textit{Journal of Diabetes and its Complications}. USA: Elsvier Science, 2016, roč.~30, č.~1, s.~67-71. ISSN~1056-8727. Dostupné z: https://doi.org/10.1016/j.jdiacomp.2015.08.020.

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