Stress response factors as hub-regulators of microRNA
biogenesis: implication to the diseased heart

J 2015

Stress response factors as hub-regulators of microRNA biogenesis: implication to the diseased heart

GURIANOVA, Veronika, Dmytro STROY, Rachele CICCOCIOPPO, Iveta GASPAROVA, Daniel PETROVIC et. al.

Základní údaje

Originální název

Stress response factors as hub-regulators of microRNA biogenesis: implication to the diseased heart

Autoři

GURIANOVA, Veronika (804 Ukrajina), Dmytro STROY (804 Ukrajina), Rachele CICCOCIOPPO (380 Itálie), Iveta GASPAROVA (703 Slovensko), Daniel PETROVIC (705 Slovinsko), Miroslav SOUČEK (203 Česká republika, domácí), Victor DOSENKO (804 Ukrajina) a Peter KRUŽLIAK (203 Česká republika, garant)

Vydání

CELL BIOCHEMISTRY AND FUNCTION, Hoboken, Wiley-Blackwell, 2015, 0263-6484

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.016

Kód RIV

RIV/00216224:14110/15:00087013

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1002/cbf.3151

UT WoS

000367919800001

Klíčová slova anglicky

miRNAs biogenesis; stress response; hub-mechanisms; cardiac pathophysiology

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 4. 2016 14:45, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

MicroRNAs (miRNAs) are important regulators of heart function and then an intriguing therapeutic target for plenty of diseases. The problem raised is that many data in this area are contradictory, thus limiting the use of miRNA-based therapy. The goal of this review is to describe the hub-mechanisms regulating the biogenesis and function of miRNAs, which could help in clarifying some contradictions in the miRNA world. With this scope, we analyse an array of factors, including several known agents of stress response, mediators of epigenetic changes, regulators of alternative splicing, RNA editing, protein synthesis and folding and proteolytic systems. All these factors are important in cardiovascular function and most of them regulate miRNA biogenesis, but their influence on miRNAs was shown for non-cardiac cells or some specific cardiac pathologies. Finally, we consider that studying the stress response factors, which are upstream regulators of miRNA biogenesis, in the diseased heart could help in (1) explaining some contradictions concerning miRNAs in heart pathology, (2) making the role of miRNAs in pathogenesis of cardiovascular disease more clear, and therefore, (3) getting powerful targets for its molecular therapy.

Citovat

GURIANOVA, Veronika, Dmytro STROY, Rachele CICCOCIOPPO, Iveta GASPAROVA, Daniel PETROVIC, Miroslav SOUČEK, Victor DOSENKO a Peter KRUŽLIAK. Stress response factors as hub-regulators of microRNA biogenesis: implication to the diseased heart. CELL BIOCHEMISTRY AND FUNCTION. Hoboken: Wiley-Blackwell, 2015, roč. 33, č. 8, s. 509-518. ISSN 0263-6484. Dostupné z: https://dx.doi.org/10.1002/cbf.3151.

@article{1339374,
   author = {Gurianova, Veronika and Stroy, Dmytro and Ciccocioppo, Rachele and Gasparova, Iveta and Petrovic, Daniel and Souček, Miroslav and Dosenko, Victor and Kružliak, Peter},
   article_location = {Hoboken},
   article_number = {8},
   doi = {http://dx.doi.org/10.1002/cbf.3151},
   keywords = {miRNAs biogenesis; stress response; hub-mechanisms; cardiac pathophysiology},
   language = {eng},
   issn = {0263-6484},
   journal = {CELL BIOCHEMISTRY AND FUNCTION},
   title = {Stress response factors as hub-regulators of microRNA biogenesis: implication to the diseased heart},
   volume = {33},
   year = {2015}
}

TY  - JOUR
ID  - 1339374
AU  - Gurianova, Veronika - Stroy, Dmytro - Ciccocioppo, Rachele - Gasparova, Iveta - Petrovic, Daniel - Souček, Miroslav - Dosenko, Victor - Kružliak, Peter
PY  - 2015
TI  - Stress response factors as hub-regulators of microRNA biogenesis: implication to the diseased heart
JF  - CELL BIOCHEMISTRY AND FUNCTION
VL  - 33
IS  - 8
SP  - 509-518
EP  - 509-518
PB  - Wiley-Blackwell
SN  - 02636484
KW  - miRNAs biogenesis
KW  - stress response
KW  - hub-mechanisms
KW  - cardiac pathophysiology
N2  - MicroRNAs (miRNAs) are important regulators of heart function and then an intriguing therapeutic target for plenty of diseases. The problem raised is that many data in this area are contradictory, thus limiting the use of miRNA-based therapy. The goal of this review is to describe the hub-mechanisms regulating the biogenesis and function of miRNAs, which could help in clarifying some contradictions in the miRNA world. With this scope, we analyse an array of factors, including several known agents of stress response, mediators of epigenetic changes, regulators of alternative splicing, RNA editing, protein synthesis and folding and proteolytic systems. All these factors are important in cardiovascular function and most of them regulate miRNA biogenesis, but their influence on miRNAs was shown for non-cardiac cells or some specific cardiac pathologies. Finally, we consider that studying the stress response factors, which are upstream regulators of miRNA biogenesis, in the diseased heart could help in (1) explaining some contradictions concerning miRNAs in heart pathology, (2) making the role of miRNAs in pathogenesis of cardiovascular disease more clear, and therefore, (3) getting powerful targets for its molecular therapy.
ER  -

GURIANOVA, Veronika, Dmytro STROY, Rachele CICCOCIOPPO, Iveta GASPAROVA, Daniel PETROVIC, Miroslav SOUČEK, Victor DOSENKO a Peter KRUŽLIAK. Stress response factors as hub-regulators of microRNA biogenesis: implication to the diseased heart. \textit{CELL BIOCHEMISTRY AND FUNCTION}. Hoboken: Wiley-Blackwell, 2015, roč.~33, č.~8, s.~509-518. ISSN~0263-6484. Dostupné z: https://dx.doi.org/10.1002/cbf.3151.

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