A genome-wide association study of marginal zone lymphoma shows association to the HLA region
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VIJAI, Joseph; Zhaoming WANG; Sonja I. BERNDT; Christine F. SKIBOLA; Susan L. SLAGER; Silvia de SANJOSE; Mads MELBYE; Benght GLIMELIUS; Paige M. BRACCI; Lucia CONDE; Brenda M. BIRMANN; Sophia S. WANG; Angela R. BROOKS-WILSON; Qing LAN; Paul I.W. BAKKER; Roel C.H. VERMEULEN; Carol PORTLOCK; Stephen M. ANSELL; Brian K. LINK; Jacques RIBY; Kari E. NORTH; Jian GU; Henrik HJALGRIM; Wendy COZEN; Nikolaus BECKER; Lauren R. TERAS; John J. SPINELLI; Jenny TURNER; YaweiW ZHANG; Mark P. PURDUE; Graham G. GILES; Rachel S. KELLY; Anne ZELENIUCH-JACQUOTTE; Maria Grazia ENNAS; Alain MONNEREAU; Kimberly A. BERTRAND; Demetrius ALBANES; Tracy LIGHTFOOT; Meredith YEAGER; Charles C. CHUNG; Laurie BURDETT; Amy HUTCHINSON; Charles LAWRENCE; Rebecca MONTALVAN; Liming LIANG; Jinyan HUANG; Baoshan MA; Danylo J. VILLANO; Ann MARIA; Marina CORINES; Tinu THOMAS; Anne J. NOVAK; Ahmet DOGAN; Mark LIEBOW; Carrie A. THOMPSON; Thomas E. WITZIG; Thomas M. HABERMANN; George J. WEINER; Martyn T. SMITH; Elizabeth HOLLY; Rebecca D. JACKSON; Lesley F. TINKER; Yuanging YE; Hans-Olov ADAMI; Karin E. SMEDBY; Anneclaire DE ROOS; Patricia HARTGE; Lindsay M. MORTON; Richard K. SEVERSON; Yolanda BENAVENTE; Paolo BOFFETTA; Paul BRENNAN; Lenka FORETOVÁ; Marc MAYNADIE; James MCKAY; Anthony STAINES; W. Ryan DIVER; Claire M. VAJDIC; Bruce K. ARMSTRONG; Anne KRICKER; TongzhangZ ZHENG; Theodore R. HOLFORD; Gianluca SEVERI; Paolo VINEIS; Giovanni M. FERRI; Rosalia RICCO; Lucia MILIGI; Jacqueline CLAVEL; Edward GIOVANNUCCI; Peter KRAFT; Jarmo VIRTAMO; Alex SMITH; Eleanor KANE; Eve ROMAN; Brian C.H. CHIU; Joseph F. FRAUMENI; Xifeng WU; James R. CERHAN; Kenneth OFFIT; Stephen J. CHANOCK; Nathaniel ROTHMAN a Alexandra NIETERS
Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P - 3.95 x 10(-15)) and HLA-B (rs2922994, P - 2.43 x 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.
VIJAI, Joseph; Zhaoming WANG; Sonja I. BERNDT; Christine F. SKIBOLA; Susan L. SLAGER; Silvia de SANJOSE; Mads MELBYE; Benght GLIMELIUS; Paige M. BRACCI; Lucia CONDE; Brenda M. BIRMANN; Sophia S. WANG; Angela R. BROOKS-WILSON; Qing LAN; Paul I.W. BAKKER; Roel C.H. VERMEULEN; Carol PORTLOCK; Stephen M. ANSELL; Brian K. LINK; Jacques RIBY; Kari E. NORTH; Jian GU; Henrik HJALGRIM; Wendy COZEN; Nikolaus BECKER; Lauren R. TERAS; John J. SPINELLI; Jenny TURNER; YaweiW ZHANG; Mark P. PURDUE; Graham G. GILES; Rachel S. KELLY; Anne ZELENIUCH-JACQUOTTE; Maria Grazia ENNAS; Alain MONNEREAU; Kimberly A. BERTRAND; Demetrius ALBANES; Tracy LIGHTFOOT; Meredith YEAGER; Charles C. CHUNG; Laurie BURDETT; Amy HUTCHINSON; Charles LAWRENCE; Rebecca MONTALVAN; Liming LIANG; Jinyan HUANG; Baoshan MA; Danylo J. VILLANO; Ann MARIA; Marina CORINES; Tinu THOMAS; Anne J. NOVAK; Ahmet DOGAN; Mark LIEBOW; Carrie A. THOMPSON; Thomas E. WITZIG; Thomas M. HABERMANN; George J. WEINER; Martyn T. SMITH; Elizabeth HOLLY; Rebecca D. JACKSON; Lesley F. TINKER; Yuanging YE; Hans-Olov ADAMI; Karin E. SMEDBY; Anneclaire DE ROOS; Patricia HARTGE; Lindsay M. MORTON; Richard K. SEVERSON; Yolanda BENAVENTE; Paolo BOFFETTA; Paul BRENNAN; Lenka FORETOVÁ; Marc MAYNADIE; James MCKAY; Anthony STAINES; W. Ryan DIVER; Claire M. VAJDIC; Bruce K. ARMSTRONG; Anne KRICKER; TongzhangZ ZHENG; Theodore R. HOLFORD; Gianluca SEVERI; Paolo VINEIS; Giovanni M. FERRI; Rosalia RICCO; Lucia MILIGI; Jacqueline CLAVEL; Edward GIOVANNUCCI; Peter KRAFT; Jarmo VIRTAMO; Alex SMITH; Eleanor KANE; Eve ROMAN; Brian C.H. CHIU; Joseph F. FRAUMENI; Xifeng WU; James R. CERHAN; Kenneth OFFIT; Stephen J. CHANOCK; Nathaniel ROTHMAN a Alexandra NIETERS. A genome-wide association study of marginal zone lymphoma shows association to the HLA region. Nature Communications. London: Nature Publishing Group, 2015, roč. 6, UNSP 5751, s. 1-7. ISSN 2041-1723. Dostupné z: https://doi.org/10.1038/ncomms6751.
@article{1339648, author = {Vijai, Joseph and Wang, Zhaoming and Berndt, Sonja I. and Skibola, Christine F. and Slager, Susan L. and Sanjose, Silvia de and Melbye, Mads and Glimelius, Benght and Bracci, Paige M. and Conde, Lucia and Birmann, Brenda M. and Wang, Sophia S. and BrooksandWilson, Angela R. and Lan, Qing and Bakker, Paul I.W. and Vermeulen, Roel C.H. and Portlock, Carol and Ansell, Stephen M. and Link, Brian K. and Riby, Jacques and North, Kari E. and Gu, Jian and Hjalgrim, Henrik and Cozen, Wendy and Becker, Nikolaus and Teras, Lauren R. and Spinelli, John J. and Turner, Jenny and Zhang, YaweiW and Purdue, Mark P. and Giles, Graham G. and Kelly, Rachel S. and ZeleniuchandJacquotte, Anne and Ennas, Maria Grazia and Monnereau, Alain and Bertrand, Kimberly A. and Albanes, Demetrius and Lightfoot, Tracy and Yeager, Meredith and Chung, Charles C. and Burdett, Laurie and Hutchinson, Amy and Lawrence, Charles and Montalvan, Rebecca and Liang, Liming and Huang, Jinyan and Ma, Baoshan and Villano, Danylo J. and Maria, Ann and Corines, Marina and Thomas, Tinu and Novak, Anne J. and Dogan, Ahmet and Liebow, Mark and Thompson, Carrie A. and Witzig, Thomas E. and Habermann, Thomas M. and Weiner, George J. and Smith, Martyn T. and Holly, Elizabeth and Jackson, Rebecca D. and Tinker, Lesley F. and Ye, Yuanging and Adami, HansandOlov and Smedby, Karin E. and De Roos, Anneclaire and Hartge, Patricia and Morton, Lindsay M. and Severson, Richard K. and Benavente, Yolanda and Boffetta, Paolo and Brennan, Paul and Foretová, Lenka and Maynadie, Marc and McKay, James and Staines, Anthony and Diver, W. Ryan and Vajdic, Claire M. and Armstrong, Bruce K. and Kricker, Anne and Zheng, TongzhangZ and Holford, Theodore R. and Severi, Gianluca and Vineis, Paolo and Ferri, Giovanni M. and Ricco, Rosalia and Miligi, Lucia and Clavel, Jacqueline and Giovannucci, Edward and Kraft, Peter and Virtamo, Jarmo and Smith, Alex and Kane, Eleanor and Roman, Eve and Chiu, Brian C.H. and Fraumeni, Joseph F. and Wu, Xifeng and Cerhan, James R. and Offit, Kenneth and Chanock, Stephen J. and Rothman, Nathaniel and Nieters, Alexandra}, article_location = {London}, article_number = {UNSP 5751}, doi = {https://doi.org/10.1038/ncomms6751}, keywords = {Marginal zone lymphoma; non-Hodgkin lymphoma}, language = {eng}, issn = {2041-1723}, journal = {Nature Communications}, title = {A genome-wide association study of marginal zone lymphoma shows association to the HLA region}, volume = {6}, year = {2015} }
TY - JOUR ID - 1339648 AU - Vijai, Joseph - Wang, Zhaoming - Berndt, Sonja I. - Skibola, Christine F. - Slager, Susan L. - Sanjose, Silvia de - Melbye, Mads - Glimelius, Benght - Bracci, Paige M. - Conde, Lucia - Birmann, Brenda M. - Wang, Sophia S. - Brooks-Wilson, Angela R. - Lan, Qing - Bakker, Paul I.W. - Vermeulen, Roel C.H. - Portlock, Carol - Ansell, Stephen M. - Link, Brian K. - Riby, Jacques - North, Kari E. - Gu, Jian - Hjalgrim, Henrik - Cozen, Wendy - Becker, Nikolaus - Teras, Lauren R. - Spinelli, John J. - Turner, Jenny - Zhang, YaweiW - Purdue, Mark P. - Giles, Graham G. - Kelly, Rachel S. - Zeleniuch-Jacquotte, Anne - Ennas, Maria Grazia - Monnereau, Alain - Bertrand, Kimberly A. - Albanes, Demetrius - Lightfoot, Tracy - Yeager, Meredith - Chung, Charles C. - Burdett, Laurie - Hutchinson, Amy - Lawrence, Charles - Montalvan, Rebecca - Liang, Liming - Huang, Jinyan - Ma, Baoshan - Villano, Danylo J. - Maria, Ann - Corines, Marina - Thomas, Tinu - Novak, Anne J. - Dogan, Ahmet - Liebow, Mark - Thompson, Carrie A. - Witzig, Thomas E. - Habermann, Thomas M. - Weiner, George J. - Smith, Martyn T. - Holly, Elizabeth - Jackson, Rebecca D. - Tinker, Lesley F. - Ye, Yuanging - Adami, Hans-Olov - Smedby, Karin E. - De Roos, Anneclaire - Hartge, Patricia - Morton, Lindsay M. - Severson, Richard K. - Benavente, Yolanda - Boffetta, Paolo - Brennan, Paul - Foretová, Lenka - Maynadie, Marc - McKay, James - Staines, Anthony - Diver, W. Ryan - Vajdic, Claire M. - Armstrong, Bruce K. - Kricker, Anne - Zheng, TongzhangZ - Holford, Theodore R. - Severi, Gianluca - Vineis, Paolo - Ferri, Giovanni M. - Ricco, Rosalia - Miligi, Lucia - Clavel, Jacqueline - Giovannucci, Edward - Kraft, Peter - Virtamo, Jarmo - Smith, Alex - Kane, Eleanor - Roman, Eve - Chiu, Brian C.H. - Fraumeni, Joseph F. - Wu, Xifeng - Cerhan, James R. - Offit, Kenneth - Chanock, Stephen J. - Rothman, Nathaniel - Nieters, Alexandra PY - 2015 TI - A genome-wide association study of marginal zone lymphoma shows association to the HLA region JF - Nature Communications VL - 6 IS - UNSP 5751 SP - 1-7 EP - 1-7 PB - Nature Publishing Group SN - 20411723 KW - Marginal zone lymphoma KW - non-Hodgkin lymphoma N2 - Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P - 3.95 x 10(-15)) and HLA-B (rs2922994, P - 2.43 x 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility. ER -
VIJAI, Joseph; Zhaoming WANG; Sonja I. BERNDT; Christine F. SKIBOLA; Susan L. SLAGER; Silvia de SANJOSE; Mads MELBYE; Benght GLIMELIUS; Paige M. BRACCI; Lucia CONDE; Brenda M. BIRMANN; Sophia S. WANG; Angela R. BROOKS-WILSON; Qing LAN; Paul I.W. BAKKER; Roel C.H. VERMEULEN; Carol PORTLOCK; Stephen M. ANSELL; Brian K. LINK; Jacques RIBY; Kari E. NORTH; Jian GU; Henrik HJALGRIM; Wendy COZEN; Nikolaus BECKER; Lauren R. TERAS; John J. SPINELLI; Jenny TURNER; YaweiW ZHANG; Mark P. PURDUE; Graham G. GILES; Rachel S. KELLY; Anne ZELENIUCH-JACQUOTTE; Maria Grazia ENNAS; Alain MONNEREAU; Kimberly A. BERTRAND; Demetrius ALBANES; Tracy LIGHTFOOT; Meredith YEAGER; Charles C. CHUNG; Laurie BURDETT; Amy HUTCHINSON; Charles LAWRENCE; Rebecca MONTALVAN; Liming LIANG; Jinyan HUANG; Baoshan MA; Danylo J. VILLANO; Ann MARIA; Marina CORINES; Tinu THOMAS; Anne J. NOVAK; Ahmet DOGAN; Mark LIEBOW; Carrie A. THOMPSON; Thomas E. WITZIG; Thomas M. HABERMANN; George J. WEINER; Martyn T. SMITH; Elizabeth HOLLY; Rebecca D. JACKSON; Lesley F. TINKER; Yuanging YE; Hans-Olov ADAMI; Karin E. SMEDBY; Anneclaire DE ROOS; Patricia HARTGE; Lindsay M. MORTON; Richard K. SEVERSON; Yolanda BENAVENTE; Paolo BOFFETTA; Paul BRENNAN; Lenka FORETOVÁ; Marc MAYNADIE; James MCKAY; Anthony STAINES; W. Ryan DIVER; Claire M. VAJDIC; Bruce K. ARMSTRONG; Anne KRICKER; TongzhangZ ZHENG; Theodore R. HOLFORD; Gianluca SEVERI; Paolo VINEIS; Giovanni M. FERRI; Rosalia RICCO; Lucia MILIGI; Jacqueline CLAVEL; Edward GIOVANNUCCI; Peter KRAFT; Jarmo VIRTAMO; Alex SMITH; Eleanor KANE; Eve ROMAN; Brian C.H. CHIU; Joseph F. FRAUMENI; Xifeng WU; James R. CERHAN; Kenneth OFFIT; Stephen J. CHANOCK; Nathaniel ROTHMAN a Alexandra NIETERS. A genome-wide association study of marginal zone lymphoma shows association to the HLA region. \textit{Nature Communications}. London: Nature Publishing Group, 2015, roč.~6, UNSP 5751, s.~1-7. ISSN~2041-1723. Dostupné z: https://doi.org/10.1038/ncomms6751.