Thermodynamic, Kinetic and Structural  Study of Transition
Metal Complexes of NOTA ligand

D 2015

Thermodynamic, Kinetic and Structural Study of Transition Metal Complexes of NOTA ligand

ŠEVČÍKOVÁ, Romana; Jakub VANĚK; Přemysl LUBAL; Vojtěch KUBÍČEK; Zuzana BÖHMOVÁ et al.

Základní údaje

Originální název

Thermodynamic, Kinetic and Structural Study of Transition Metal Complexes of NOTA ligand

Autoři

ŠEVČÍKOVÁ, Romana; Jakub VANĚK; Přemysl LUBAL; Vojtěch KUBÍČEK; Zuzana BÖHMOVÁ; Jan KOTEK a Petr HERMANN

Vydání

Wroclaw, Acta of the International Symposia on Metal Complexes – ISMEC Acta vol. 5 (2015), od s. 47-48, 2 s. 2015

Nakladatel

University of Wroclaw

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

10402 Inorganic and nuclear chemistry

Stát vydavatele

Polsko

Utajení

není předmětem státního či obchodního tajemství

Forma vydání

tištěná verze "print"

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/15:00081669

Organizační jednotka

Přírodovědecká fakulta

ISSN

Klíčová slova anglicky

Cu(II) ion; NOTA macrocyclic ligand

Štítky

AKR

Změněno: 28. 4. 2016 15:52, Ing. Andrea Mikešková

Anotace

V originále

Triaza-macrocyclic ligands are recently utilized to bind some radioisotopes for application in medicinal chemistry (60–64,67Cu, 66–68Ga, 86,90Y, 111In) [1,2]. Among them, copper radioisotopes are promising for application in diagnosis (positron emission tomography - PET, 64Cu with half-life 12.8 h) or in radio-immunotherapy (67Cu with half-life 62 h) [1,2]. Cu(II) ion should be bound in the form of metal complexes of high thermodynamic stability and kinetic inertness, which are required for the use in vivo for medical purposes. One of the most frequently used triaaza-macrocyclic ligand is H3nota (1,4,7-triazacyclononane-1,4,7-triacetic acid). Despite that, broad range of basic data regarding structural and some thermodynamic properties and kinetic behavior of its complexes has not been reported. Scheme: Formula of 1,4,7-triazacyclononane-1,4,7-triacetic acid (H3nota) Here, we report on protonation constants as well as stability constants of metal complexes (Cu(II), Zn(II), Ni(II), Co(II), Cd(II), Pb(II), Ca(II), Mg(II)) which show that the ligand cavity is too small for large metal ions and, therefore, the stability constants are significantly decreasing. This observation was confirmed for molecular structure of [Pb(nota)]– complex found in the solid state. The kinetic studies show the fast formation and slow dissociation of copper(II) complexes and, therefore, this ligand is suitable for sequestering of copper radioisotopes utilized in nuclear medicine. The results are compared with rate constants obtained for open-chain ligands, e.g. EDTA, or other triazamacrocyclic ligands without pendant arms.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

GA13-08336S, projekt VaV

Název: Hybridní materiály založené na makrocyklických ligandech pro využití v medicíně

Investor: Grantová agentura ČR, Hybridní materiály založené na makrocyklických ligandech pro využití v medicíně

Citovat

ŠEVČÍKOVÁ, Romana; Jakub VANĚK; Přemysl LUBAL; Vojtěch KUBÍČEK; Zuzana BÖHMOVÁ; Jan KOTEK a Petr HERMANN. Thermodynamic, Kinetic and Structural Study of Transition Metal Complexes of NOTA ligand. In Acta of the International Symposia on Metal Complexes – ISMEC Acta vol. 5 (2015). Wroclaw: University of Wroclaw, 2015, s. 47-48. ISSN 2239-2459.

@inproceedings{1340830,
   author = {Ševčíková, Romana and Vaněk, Jakub and Lubal, Přemysl and Kubíček, Vojtěch and Böhmová, Zuzana and Kotek, Jan and Hermann, Petr},
   address = {Wroclaw},
   booktitle = {Acta of the International Symposia on Metal Complexes – ISMEC Acta vol. 5 (2015)},
   keywords = {Cu(II) ion; NOTA macrocyclic ligand},
   howpublished = {tištěná verze "print"},
   language = {eng},
   location = {Wroclaw},
   pages = {47-48},
   publisher = {University of Wroclaw},
   title = {Thermodynamic, Kinetic and Structural Study of Transition Metal Complexes of NOTA ligand},
   year = {2015}
}

TY  - CONF
ID  - 1340830
AU  - Ševčíková, Romana - Vaněk, Jakub - Lubal, Přemysl - Kubíček, Vojtěch - Böhmová, Zuzana - Kotek, Jan - Hermann, Petr
PY  - 2015
TI  - Thermodynamic, Kinetic and Structural Study of Transition Metal Complexes of NOTA ligand
PB  - University of Wroclaw
CY  - Wroclaw
KW  - Cu(II) ion
KW  - NOTA macrocyclic ligand
N2  - Triaza-macrocyclic ligands are recently utilized to bind some radioisotopes for application in medicinal chemistry (60–64,67Cu, 66–68Ga, 86,90Y, 111In) [1,2]. Among them, copper radioisotopes are promising for application in diagnosis (positron emission tomography - PET, 64Cu with half-life 12.8 h) or in radio-immunotherapy (67Cu with half-life 62 h) [1,2]. Cu(II) ion should be bound in the form of metal complexes of high thermodynamic stability and kinetic inertness, which are required for the use in vivo for medical purposes. One of the most frequently used triaaza-macrocyclic ligand is H3nota (1,4,7-triazacyclononane-1,4,7-triacetic acid). Despite that, broad range of basic data regarding structural and some thermodynamic properties and kinetic behavior of its complexes has not been reported. Scheme: Formula of 1,4,7-triazacyclononane-1,4,7-triacetic acid (H3nota) Here, we report on protonation constants as well as stability constants of metal complexes (Cu(II), Zn(II), Ni(II), Co(II), Cd(II), Pb(II), Ca(II), Mg(II)) which show that the ligand cavity is too small for large metal ions and, therefore, the stability constants are significantly decreasing. This observation was confirmed for molecular structure of [Pb(nota)]– complex found in the solid state. The kinetic studies show the fast formation and slow dissociation of copper(II) complexes and, therefore, this ligand is suitable for sequestering of copper radioisotopes utilized in nuclear medicine. The results are compared with rate constants obtained for open-chain ligands, e.g. EDTA, or other triazamacrocyclic ligands without pendant arms.
ER  -

ŠEVČÍKOVÁ, Romana; Jakub VANĚK; Přemysl LUBAL; Vojtěch KUBÍČEK; Zuzana BÖHMOVÁ; Jan KOTEK a Petr HERMANN. Thermodynamic, Kinetic and Structural Study of Transition Metal Complexes of NOTA ligand. In \textit{Acta of the International Symposia on Metal Complexes – ISMEC Acta vol. 5 (2015)}. Wroclaw: University of Wroclaw, 2015, s.~47-48. ISSN~2239-2459.

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