Thermodynamic and Kinetic Study of Mono- and
Bis-triazamacrocyclic Ligands and their Transition Metal
Complexes Mimicking Hydrolytic Enzyme Activity

D 2015

Thermodynamic and Kinetic Study of Mono- and Bis-triazamacrocyclic Ligands and their Transition Metal Complexes Mimicking Hydrolytic Enzyme Activity

BARTOŠKOVÁ, Marie; Jakub VANĚK; Daniel BÍM; Přemysl LUBAL; Jana HODAČOVÁ et al.

Základní údaje

Originální název

Thermodynamic and Kinetic Study of Mono- and Bis-triazamacrocyclic Ligands and their Transition Metal Complexes Mimicking Hydrolytic Enzyme Activity

Autoři

BARTOŠKOVÁ, Marie; Jakub VANĚK; Daniel BÍM; Přemysl LUBAL a Jana HODAČOVÁ

Vydání

Wroclaw, Acta of the International Symposia on Metal Complexes – ISMEC Acta Vol.5 (2015), od s. 70-71, 2 s. 2015

Nakladatel

University of Wroclaw

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

10402 Inorganic and nuclear chemistry

Stát vydavatele

Polsko

Utajení

není předmětem státního či obchodního tajemství

Forma vydání

tištěná verze "print"

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/15:00081671

Organizační jednotka

Přírodovědecká fakulta

ISSN

Klíčová slova anglicky

coper(II) ion; bis(macrocyclic) ligand

Změněno: 28. 4. 2016 15:53, Ing. Andrea Mikešková

Anotace

V originále

Polyaza-macrocyclic ligands are recently utilized to bind some radioisotopes for application in medicinal chemistry (60–64,67Cu, 66–68Ga, 86,90Y, 111In) [1,2] and the formed metal complexes of high thermodynamic stability and kinetic inertness are required for their use in vivo for medical purposes. Several copper(II) and zinc(II) complexes of bis-polyaza-macrocyclic ligands catalyse some chemical reactions and therefore they can be used as model systems mimicking enzymes activity. In this work, the protonation constants of novel macrocyclic ligands as well as stability constants of their copper(II) and zinc(II) complexes were determined by glass-electrode potentiometry and molecular absorption spectroscopy. The formation of the copper(II) complexes of both ligands is accelerated with increased pH. The dissociation of both copper(II) complexes does not differ within experimental error indicating no cooperative effect for binucleating ligand. However, both complexes demonstrate significant catalytic activity in hydrolysis of model phosphodiester compounds.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

GA13-08336S, projekt VaV

Název: Hybridní materiály založené na makrocyklických ligandech pro využití v medicíně

Investor: Grantová agentura ČR, Hybridní materiály založené na makrocyklických ligandech pro využití v medicíně

Citovat

BARTOŠKOVÁ, Marie; Jakub VANĚK; Daniel BÍM; Přemysl LUBAL a Jana HODAČOVÁ. Thermodynamic and Kinetic Study of Mono- and Bis-triazamacrocyclic Ligands and their Transition Metal Complexes Mimicking Hydrolytic Enzyme Activity. In Acta of the International Symposia on Metal Complexes – ISMEC Acta Vol.5 (2015). Wroclaw: University of Wroclaw, 2015, s. 70-71. ISSN 2239-2459.

@inproceedings{1340854,
   author = {Bartošková, Marie and Vaněk, Jakub and Bím, Daniel and Lubal, Přemysl and Hodačová, Jana},
   address = {Wroclaw},
   booktitle = {Acta of the International Symposia on Metal Complexes – ISMEC Acta Vol.5 (2015)},
   keywords = {coper(II) ion; bis(macrocyclic) ligand},
   howpublished = {tištěná verze "print"},
   language = {eng},
   location = {Wroclaw},
   pages = {70-71},
   publisher = {University of Wroclaw},
   title = {Thermodynamic and Kinetic Study of Mono- and Bis-triazamacrocyclic Ligands and their Transition Metal Complexes Mimicking Hydrolytic Enzyme Activity},
   year = {2015}
}

TY  - CONF
ID  - 1340854
AU  - Bartošková, Marie - Vaněk, Jakub - Bím, Daniel - Lubal, Přemysl - Hodačová, Jana
PY  - 2015
TI  - Thermodynamic and Kinetic Study of Mono- and Bis-triazamacrocyclic Ligands and their Transition Metal Complexes Mimicking Hydrolytic Enzyme Activity
PB  - University of Wroclaw
CY  - Wroclaw
KW  - coper(II) ion
KW  - bis(macrocyclic) ligand
N2  - Polyaza-macrocyclic ligands are recently utilized to bind some radioisotopes for application in medicinal chemistry (60–64,67Cu, 66–68Ga, 86,90Y, 111In) [1,2] and the formed metal complexes of high thermodynamic stability and kinetic inertness are required for their use in vivo for medical purposes. Several copper(II) and zinc(II) complexes of bis-polyaza-macrocyclic ligands catalyse some chemical reactions and therefore they can be used as model systems mimicking enzymes activity. In this work, the protonation constants of novel macrocyclic ligands as well as stability constants of their copper(II) and zinc(II) complexes were determined by glass-electrode potentiometry and molecular absorption spectroscopy. The formation of the copper(II) complexes of both ligands is accelerated with increased pH. The dissociation of both copper(II) complexes does not differ within experimental error indicating no cooperative effect for binucleating ligand. However, both complexes demonstrate significant catalytic activity in hydrolysis of model phosphodiester compounds.
ER  -

BARTOŠKOVÁ, Marie; Jakub VANĚK; Daniel BÍM; Přemysl LUBAL a Jana HODAČOVÁ. Thermodynamic and Kinetic Study of Mono- and Bis-triazamacrocyclic Ligands and their Transition Metal Complexes Mimicking Hydrolytic Enzyme Activity. In \textit{Acta of the International Symposia on Metal Complexes – ISMEC Acta Vol.5 (2015)}. Wroclaw: University of Wroclaw, 2015, s.~70-71. ISSN~2239-2459.

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