Method of Determination of Diagnosis and Prognosis in Patients
with B-cell Chronic Lymphocytic leukemia and oligonucleotides
for use in this method

P 2015

Method of Determination of Diagnosis and Prognosis in Patients with B-cell Chronic Lymphocytic leukemia and oligonucleotides for use in this method

BRYJA, Vítězslav, Pavel KREJČÍ, Markéta KAUCKÁ, Šárka POSPÍŠILOVÁ, Jiří MAYER et. al.

Základní údaje

Originální název

Method of Determination of Diagnosis and Prognosis in Patients with B-cell Chronic Lymphocytic leukemia and oligonucleotides for use in this method

Autoři

BRYJA, Vítězslav (203 Česká republika, garant, domácí), Pavel KREJČÍ (203 Česká republika, domácí), Markéta KAUCKÁ (203 Česká republika), Šárka POSPÍŠILOVÁ (203 Česká republika, domácí), Jiří MAYER (203 Česká republika, domácí), Alois KOZUBÍK (203 Česká republika, domácí), Jana KOTAŠKOVÁ (203 Česká republika, domácí) a Karla PLEVOVÁ (203 Česká republika, domácí)

Vydání

Číslo: US 9,057,106, Vydavatel: United States Patents and Trademark, Místo vydání: USA, Název vlastníka: Masarykova univerzita, 2015

Další údaje

Jazyk

angličtina

Typ výsledku

Patent

Obor

Genetika a molekulární biologie

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14310/15:00087216

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

B Cell; Chronic Lymphotetic Leukemia; WNT/PCP Signaling Pathway

Štítky

AKR, rivok

Změněno: 8. 4. 2016 09:00, Ing. Andrea Mikešková

Anotace

V originále

The invention provides a method of determination of diagnosis and prognosis of B-cell chronic lymphocytic leukemia from a biological sample collected from the body of a patient, wherein the status of Wnt/PCP signaling pathway is determined. Within the framework of the present invention the relation of CLL and molecular signaling pathway Wnt/PCP the components of which are markedly up-regulated in B-lymphocytes of the patients suffering from CLL was identified. The status of the Wnt/PCP signaling pathway can be determined, e.g., by the determination of the expression of components of said signaling pathway or by the determination of migration of CLL cells in the gradient of a chemokine in the presence of the ligand of said signaling pathway. The invention also relates to suitable oligonucleotides for use in the method of determination of expression of the signaling pathway components.

Citovat

BRYJA, Vítězslav, Pavel KREJČÍ, Markéta KAUCKÁ, Šárka POSPÍŠILOVÁ, Jiří MAYER, Alois KOZUBÍK, Jana KOTAŠKOVÁ a Karla PLEVOVÁ. Method of Determination of Diagnosis and Prognosis in Patients with B-cell Chronic Lymphocytic leukemia and oligonucleotides for use in this method. 2015. Patent. Číslo: US 9,057,106. Vydavatel: United States Patents and Trademark. Místo vydání: USA. Název vlastníka: Masarykova univerzita. Datum registrace: 3. 8. 2010. Datum přijetí: 16. 6. 2015.

@misc{1341556,
   author = {Bryja, Vítězslav and Krejčí, Pavel and Kaucká, Markéta and Pospíšilová, Šárka and Mayer, Jiří and Kozubík, Alois and Kotašková, Jana and Plevová, Karla},
   keywords = {B Cell; Chronic Lymphotetic Leukemia; WNT/PCP Signaling Pathway},
   language = {eng},
   title = {Method of Determination of Diagnosis and Prognosis in Patients with B-cell Chronic Lymphocytic leukemia and oligonucleotides for use in this method},
   year = {2015}
}

TY  - PAT
ID  - 1341556
AU  - Bryja, Vítězslav - Krejčí, Pavel - Kaucká, Markéta - Pospíšilová, Šárka - Mayer, Jiří - Kozubík, Alois - Kotašková, Jana - Plevová, Karla
PY  - 2015
TI  - Method of Determination of Diagnosis and Prognosis in Patients with B-cell Chronic Lymphocytic leukemia and oligonucleotides for use in this method
KW  - B Cell
KW  - Chronic Lymphotetic Leukemia
KW  - WNT/PCP Signaling Pathway
N2  - The invention provides a method of determination of diagnosis and prognosis of B-cell chronic lymphocytic leukemia from a biological sample collected from the body of a patient, wherein the status of Wnt/PCP signaling pathway is determined. Within the framework of the present invention the relation of CLL and molecular signaling pathway Wnt/PCP the components of which are markedly up-regulated in B-lymphocytes of the patients suffering from CLL was identified. The status of the Wnt/PCP signaling pathway can be determined, e.g., by the determination of the expression of components of said signaling pathway or by the determination of migration of CLL cells in the gradient of a chemokine in the presence of the ligand of said signaling pathway. The invention also relates to suitable oligonucleotides for use in the method of determination of expression of the signaling pathway components.
ER  -

BRYJA, Vítězslav, Pavel KREJČÍ, Markéta KAUCKÁ, Šárka POSPÍŠILOVÁ, Jiří MAYER, Alois KOZUBÍK, Jana KOTAŠKOVÁ a Karla PLEVOVÁ. \textit{Method of Determination of Diagnosis and Prognosis in Patients with B-cell Chronic Lymphocytic leukemia and oligonucleotides for use in this method}. 2015. Patent. Číslo: US 9,057,106. Vydavatel: United States Patents and Trademark. Místo vydání: USA. Název vlastníka: Masarykova univerzita. Datum registrace: 3. 8. 2010. Datum přijetí: 16. 6. 2015.

Podrobný výpis o publikaci