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@article{1343118,
author = {Kovaľová, Ivana and Vlčková, Eva and Bednařík, Josef},
article_location = {Hoboken},
article_number = {3},
doi = {http://dx.doi.org/10.1002/brb3.444},
keywords = {cervical spondylotic myelopathy; epidermal nerve fibers; neuropathic pain; peripheral neuropathy; skin biopsy},
language = {eng},
issn = {2162-3279},
journal = {Brain and Behavior},
title = {Broadening the spectrum of controls for skin biopsy in painful neuropathies: spondylotic cervical myelopathy patients with painful feet},
volume = {6},
year = {2016}
}
TY - JOUR
ID - 1343118
AU - Kovaľová, Ivana - Vlčková, Eva - Bednařík, Josef
PY - 2016
TI - Broadening the spectrum of controls for skin biopsy in painful neuropathies: spondylotic cervical myelopathy patients with painful feet
JF - Brain and Behavior
VL - 6
IS - 3
SP - 1-5
EP - 1-5
PB - John Wiley and Sons Inc.
SN - 21623279
KW - cervical spondylotic myelopathy
KW - epidermal nerve fibers
KW - neuropathic pain
KW - peripheral neuropathy
KW - skin biopsy
N2 - Purpose: Intraepidermal nerve fiber density (IENFD) is useful in the evaluation of small-fiber neuropathy (SFN). Recent guidelines recommend extending the spectrum of controls for IENFD assessment by evaluation of patients whose clinical picture mimics that of SFN. The aim of this study was to broaden the spectrum of IENFD controls by the assessment of patients with cervical spondylotic myelopathy (CSM) and painful feet. Methods: Evaluation of IENFD from skin biopsy samples and quantitative sensory testing (QST) were performed in a cohort of 14 CSM patients (eight men, median age: 58; range: 46–63 years), with painful feet, exhibiting no clinical or electrophysiological signs of largefiber polyneuropathy, and no risk factors for peripheral neuropathies. Results: Quantitative sensory testing abnormalities were found in all but two of the CSM patients (86%), while the IENFD values were within reference range. The mean IENFD value (6.87 2.78 fibers/mm) did not differ from that of an ageand sex-matched cohort of healthy volunteers (7.97 2.21 fibers/mm, P > 0.05). Conclusions: The study confirmed normal skin biopsy findings in patients with CSM as one of the clinical conditions mimicking SFN and provided further support for the use of IENFD assessment in case of suspicion of SFN.
ER -
KOVAĽOVÁ, Ivana, Eva VLČKOVÁ and Josef BEDNAŘÍK. Broadening the spectrum of controls for skin biopsy in painful neuropathies: spondylotic cervical myelopathy patients with painful feet. \textit{Brain and Behavior}. Hoboken: John Wiley and Sons Inc., 2016, vol.~6, No~3, p.~1-5. ISSN~2162-3279. Available from: https://dx.doi.org/10.1002/brb3.444.
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