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@article{1343514, author = {Wandeler, G and Kraus, David and Fehr, J and Conen, A and Calmy, A and Orasch, C and Battegay, M and Schmid, P and Bernasconi, E and Furrer, H}, article_location = {PHILADELPHIA}, article_number = {3}, doi = {http://dx.doi.org/10.1097/QAI.0000000000000864}, keywords = {HIV infection; alcohol consumption; mortality; cohort study; cardiovascular diseases}, language = {eng}, issn = {1525-4135}, journal = {JAIDS: Journal of Acquired Immune Deficiency Syndromes}, title = {The J-Curve in HIV: Low and Moderate Alcohol Intake Predicts Mortality but Not the Occurrence of Major Cardiovascular Events}, url = {http://dx.doi.org/10.1097/QAI.0000000000000864}, volume = {71}, year = {2016} }
TY - JOUR ID - 1343514 AU - Wandeler, G - Kraus, David - Fehr, J - Conen, A - Calmy, A - Orasch, C - Battegay, M - Schmid, P - Bernasconi, E - Furrer, H PY - 2016 TI - The J-Curve in HIV: Low and Moderate Alcohol Intake Predicts Mortality but Not the Occurrence of Major Cardiovascular Events JF - JAIDS: Journal of Acquired Immune Deficiency Syndromes VL - 71 IS - 3 SP - 302-309 EP - 302-309 PB - LIPPINCOTT WILLIAMS & WILKINS SN - 15254135 KW - HIV infection KW - alcohol consumption KW - mortality KW - cohort study KW - cardiovascular diseases UR - http://dx.doi.org/10.1097/QAI.0000000000000864 L2 - http://dx.doi.org/10.1097/QAI.0000000000000864 N2 - Objectives: In HIV-negative populations, light-to-moderate alcohol consumption is associated with a lower cardiovascular morbidity and mortality than alcohol abstention. Whether the same holds true for HIV-infected individuals has not been evaluated in detail. Design: Cohort study. Methods: Adults on antiretroviral therapy in the Swiss HIV Cohort Study with follow-up after August 2005 were included. We categorized alcohol consumption into: abstention or very low (<1 g/d), low (1-9 g/d), moderate (10-29 g/d in women and 10-39 g/d in men), and high alcohol intake. Cox proportional hazards models were used to describe the association between alcohol consumption and cardiovascular disease-free survival (combined endpoint), cardiovascular disease events (CADE) and overall survival. Baseline and time-updated risk factors for CADE were included in the models. Results: Among 9741 individuals included, there were 788 events of major CADE or death during 46,719 patient-years of follow-up, corresponding to an incidence of 1.69 events/100 person-years. Follow-up according to alcohol consumption level was 51% no or very low, 20% low, 23% moderate, and 6% high intake. As compared with no or very low alcohol intake, low (hazard ratio 0.79, 95% confidence interval 0.63 to 0.98) and moderate alcohol intakes (0.78, 0.64 to 0.95) were associated with a lower incidence of the combined endpoint. There was no significant association between alcohol consumption and CADE. Conclusions: Compared with no or very low alcohol consumption, low and moderate intake associated with a better CADE-free survival. However, this result was mainly driven by mortality and the specific impact of drinking patterns and type of alcoholic beverage on this outcome remains to be determined. ER -
WANDELER, G, David KRAUS, J FEHR, A CONEN, A CALMY, C ORASCH, M BATTEGAY, P SCHMID, E BERNASCONI a H FURRER. The J-Curve in HIV: Low and Moderate Alcohol Intake Predicts Mortality but Not the Occurrence of Major Cardiovascular Events. \textit{JAIDS: Journal of Acquired Immune Deficiency Syndromes}. PHILADELPHIA: LIPPINCOTT WILLIAMS \&{}amp; WILKINS, 2016, roč.~71, č.~3, s.~302-309. ISSN~1525-4135. Dostupné z: https://dx.doi.org/10.1097/QAI.0000000000000864.
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