Plasma Levels of Soluble CD146 Reflect the Severity of
Pulmonary Congestion Better Than Brain Natriuretic Peptide in
Acute Coronary Syndrome

J 2016

Plasma Levels of Soluble CD146 Reflect the Severity of Pulmonary Congestion Better Than Brain Natriuretic Peptide in Acute Coronary Syndrome

KUBENA, Petr; Mattia ARRIGO; Jiří PAŘENICA; Etienne GAYAT; Malha SADOUNE et al.

Základní údaje

Originální název

Plasma Levels of Soluble CD146 Reflect the Severity of Pulmonary Congestion Better Than Brain Natriuretic Peptide in Acute Coronary Syndrome

Autoři

KUBENA, Petr; Mattia ARRIGO; Jiří PAŘENICA; Etienne GAYAT; Malha SADOUNE; Eva GANOVSKÁ; Marie PAVLUŠOVÁ; Simona LITTNEROVÁ; Jindřich ŠPINAR a Alexandre MEBAZAA

Vydání

Annals of laboratory medicine, Seoul, The Korean Society for Laboratory Medicine, 2016, 2234-3806

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Francie

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.174

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/16:00090321

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Acute coronary syndrome; Myocardial infarction; Pulmonary congestion; Pulmonary edema; sCD146

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 8. 2016 15:20, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Background: Acute heart failure negatively affects short-term outcomes of patients with acute coronary syndrome (ACS). Therefore, reliable and non-invasive assessment of pulmonary congestion is needed to select patients requiring more intensive monitoring and therapy. Since plasma levels of natriuretic peptides are influenced by myocardial ischemia, they might not reliably reflect congestion in the context of ACS. The novel endothelial biomarker, soluble CD146 (sCD146), presents discriminative power for detecting the cardiac origin of acute dyspnea similar to that of natriuretic peptides and is associated with systemic congestion. We evaluated the performance of sCD146 for the assessment of pulmonary congestion in the early phase of ACS. Methods: One thousand twenty-one consecutive patients with ACS were prospectively enrolled. Plasma levels of sCD146, brain natriuretic peptide (BNP), and high-sensitive troponin T were measured within 24 hr after the onset of chest pain. Pulmonary congestion on chest radiography was determined and classified in three groups according to the degree of congestion. Results: Nine hundred twenty-seven patients with ACS were analyzed. Ninety-two (10%) patients showed signs of pulmonary edema on chest radiography. Plasma levels of sCD146 reflected the radiological severity of pulmonary congestion. Higher plasma levels of sCD146 were associated with the worse degree of pulmonary congestion. In contrast to BNP, sCD146 levels were not affected by the level of troponin T. Conclusions: The novel endothelial biomarker, sCD146, correlates with radiological severity of pulmonary congestion in the early phase of ACS and, in contrast to BNP, is not affected by the amount of myocardial cell necrosis.

Citovat

KUBENA, Petr; Mattia ARRIGO; Jiří PAŘENICA; Etienne GAYAT; Malha SADOUNE; Eva GANOVSKÁ; Marie PAVLUŠOVÁ; Simona LITTNEROVÁ; Jindřich ŠPINAR a Alexandre MEBAZAA. Plasma Levels of Soluble CD146 Reflect the Severity of Pulmonary Congestion Better Than Brain Natriuretic Peptide in Acute Coronary Syndrome. Annals of laboratory medicine. Seoul: The Korean Society for Laboratory Medicine, 2016, roč. 36, č. 4, s. 300-305. ISSN 2234-3806. Dostupné z: https://doi.org/10.3343/alm.2016.36.4.300.

@article{1349291,
   author = {Kubena, Petr and Arrigo, Mattia and Pařenica, Jiří and Gayat, Etienne and Sadoune, Malha and Ganovská, Eva and Pavlušová, Marie and Littnerová, Simona and Špinar, Jindřich and Mebazaa, Alexandre},
   article_location = {Seoul},
   article_number = {4},
   doi = {https://doi.org/10.3343/alm.2016.36.4.300},
   keywords = {Acute coronary syndrome; Myocardial infarction; Pulmonary congestion; Pulmonary edema; sCD146},
   language = {eng},
   issn = {2234-3806},
   journal = {Annals of laboratory medicine},
   title = {Plasma Levels of Soluble CD146 Reflect the Severity of Pulmonary Congestion Better Than Brain Natriuretic Peptide in Acute Coronary Syndrome},
   volume = {36},
   year = {2016}
}

TY  - JOUR
ID  - 1349291
AU  - Kubena, Petr - Arrigo, Mattia - Pařenica, Jiří - Gayat, Etienne - Sadoune, Malha - Ganovská, Eva - Pavlušová, Marie - Littnerová, Simona - Špinar, Jindřich - Mebazaa, Alexandre
PY  - 2016
TI  - Plasma Levels of Soluble CD146 Reflect the Severity of Pulmonary Congestion Better Than Brain Natriuretic Peptide in Acute Coronary Syndrome
JF  - Annals of laboratory medicine
VL  - 36
IS  - 4
SP  - 300-305
EP  - 300-305
PB  - The Korean Society for Laboratory Medicine
SN  - 22343806
KW  - Acute coronary syndrome
KW  - Myocardial infarction
KW  - Pulmonary congestion
KW  - Pulmonary edema
KW  - sCD146
N2  - Background: Acute heart failure negatively affects short-term outcomes of patients with acute coronary syndrome (ACS). Therefore, reliable and non-invasive assessment of pulmonary congestion is needed to select patients requiring more intensive monitoring and therapy. Since plasma levels of natriuretic peptides are influenced by myocardial ischemia, they might not reliably reflect congestion in the context of ACS. The novel endothelial biomarker, soluble CD146 (sCD146), presents discriminative power for detecting the cardiac origin of acute dyspnea similar to that of natriuretic peptides and is associated with systemic congestion. We evaluated the performance of sCD146 for the assessment of pulmonary congestion in the early phase of ACS. Methods: One thousand twenty-one consecutive patients with ACS were prospectively enrolled. Plasma levels of sCD146, brain natriuretic peptide (BNP), and high-sensitive troponin T were measured within 24 hr after the onset of chest pain. Pulmonary congestion on chest radiography was determined and classified in three groups according to the degree of congestion. Results: Nine hundred twenty-seven patients with ACS were analyzed. Ninety-two (10%) patients showed signs of pulmonary edema on chest radiography. Plasma levels of sCD146 reflected the radiological severity of pulmonary congestion. Higher plasma levels of sCD146 were associated with the worse degree of pulmonary congestion. In contrast to BNP, sCD146 levels were not affected by the level of troponin T. Conclusions: The novel endothelial biomarker, sCD146, correlates with radiological severity of pulmonary congestion in the early phase of ACS and, in contrast to BNP, is not affected by the amount of myocardial cell necrosis.
ER  -

KUBENA, Petr; Mattia ARRIGO; Jiří PAŘENICA; Etienne GAYAT; Malha SADOUNE; Eva GANOVSKÁ; Marie PAVLUŠOVÁ; Simona LITTNEROVÁ; Jindřich ŠPINAR a Alexandre MEBAZAA. Plasma Levels of Soluble CD146 Reflect the Severity of Pulmonary Congestion Better Than Brain Natriuretic Peptide in Acute Coronary Syndrome. \textit{Annals of laboratory medicine}. Seoul: The Korean Society for Laboratory Medicine, 2016, roč.~36, č.~4, s.~300-305. ISSN~2234-3806. Dostupné z: https://doi.org/10.3343/alm.2016.36.4.300.

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