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@article{1349638, author = {Zemánková, Petra and Lungu, Ovidiu and Hüttlová, Jitka and Keřkovský, Miloš and Žúbor, Jozef and Lipová, Petra and Bareš, Martin and Kašpárek, Tomáš}, article_location = {OXFORD}, article_number = {June}, doi = {http://dx.doi.org/10.1016/j.pnpbp.2016.01.003}, keywords = {Schizophrenia; Movement sequencing; Neurological soft signs; fMRI; Effective connectivity}, language = {eng}, issn = {0278-5846}, journal = {PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY}, title = {Neuronal substrate and effective connectivity of abnormal movement sequencing in schizophrenia}, url = {http://www.sciencedirect.com/science/article/pii/S0278584616300033}, volume = {67}, year = {2016} }
TY - JOUR ID - 1349638 AU - Zemánková, Petra - Lungu, Ovidiu - Hüttlová, Jitka - Keřkovský, Miloš - Žúbor, Jozef - Lipová, Petra - Bareš, Martin - Kašpárek, Tomáš PY - 2016 TI - Neuronal substrate and effective connectivity of abnormal movement sequencing in schizophrenia JF - PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY VL - 67 IS - June SP - 1-9 EP - 1-9 PB - PERGAMON-ELSEVIER SCIENCE LTD SN - 02785846 KW - Schizophrenia KW - Movement sequencing KW - Neurological soft signs KW - fMRI KW - Effective connectivity UR - http://www.sciencedirect.com/science/article/pii/S0278584616300033 L2 - http://www.sciencedirect.com/science/article/pii/S0278584616300033 N2 - Movement sequencing difficulties are part of the neurological soft signs (NSS), they have high clinical value because they are not always present in schizophrenia. We investigated the neuronal correlates of movement sequencing in 24 healthy controls and 24 schizophrenia patients, with (SZP SQ+) or without (SZP SQ-) sequencing difficulties. We characterized simultaneous and lagged functional connectivity between brain regions involved in movement sequencing using psychophysiological interaction (PPI) and the Granger causality modeling (GCM), respectively. Left premotor cortex (PMC) and superior parietal lobule (SPL) were specifically activated during sequential movements in all participants. Right PMC and precuneus, ipsilateral to the hand executing the task, activated during sequential movements only in healthy controls and SZP SQ-. SZP SQ+ showed hyper-activation in contralateral PMC, as compared to the other groups. PPI analysis revealed a deficit in inhibitory connections within this fronto-parietal network in SZP SQ+ during sequential task. GCM showed a significant lagged effective connectivity from right PMC to left SPL during task and rest periods in all groups and from right PMC to right precuneus in SZP SQ+ group only. Both SZP groups had a significant lagged connectivity from right to left PMC, during sequential task. Our results indicate that aberrant fronto-parietal network connectivity with cortical inhibition deficit and abnormal reliance on previous network activity are related to movement sequencing in SZP. The overactivation of motor cortex seems to be a good compensating strategy, the hyperactivation of parietal cortex is linked to motor deficit symptoms. (C) 2016 Elsevier Inc. All rights reserved. ER -
ZEMÁNKOVÁ, Petra, Ovidiu LUNGU, Jitka HÜTTLOVÁ, Miloš KEŘKOVSKÝ, Jozef ŽÚBOR, Petra LIPOVÁ, Martin BAREŠ a Tomáš KAŠPÁREK. Neuronal substrate and effective connectivity of abnormal movement sequencing in schizophrenia. \textit{PROGRESS IN NEURO-PSYCHOPHARMACOLOGY \&{} BIOLOGICAL PSYCHIATRY}. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2016, roč.~67, June, s.~1-9. ISSN~0278-5846. Dostupné z: https://dx.doi.org/10.1016/j.pnpbp.2016.01.003.
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