Další formáty:
BibTeX
LaTeX
RIS
@article{1350719,
author = {Horská, Kateřina and Rudá, Jana and Babinská, Zuzana and Karpisek, Michal and Demlová, Regina and Opatřilová, Radka and Suchý, Pavel and Kotolová, Hana},
article_location = {Oxford},
article_number = {"neuvedeno"},
doi = {http://dx.doi.org/10.1016/j.psyneuen.2016.07.218},
keywords = {Adipokine; Adipose tissue; Dyslipidemia; Leptin; Olanzapine; Sprague-Dawley rats},
language = {eng},
issn = {0306-4530},
journal = {Psychoneuroendocrinology},
title = {Olanzapine-depot administration induces time-dependent changes inadipose tissue endocrine function in rats},
url = {http://www.sciencedirect.com/science/article/pii/S0306453016304930},
volume = {73},
year = {2016}
}
TY - JOUR
ID - 1350719
AU - Horská, Kateřina - Rudá, Jana - Babinská, Zuzana - Karpisek, Michal - Demlová, Regina - Opatřilová, Radka - Suchý, Pavel - Kotolová, Hana
PY - 2016
TI - Olanzapine-depot administration induces time-dependent changes inadipose tissue endocrine function in rats
JF - Psychoneuroendocrinology
VL - 73
IS - "neuvedeno"
SP - 177-185
EP - 177-185
PB - Pergamon-Elsevier Science LTD
SN - 03064530
KW - Adipokine
KW - Adipose tissue
KW - Dyslipidemia
KW - Leptin
KW - Olanzapine
KW - Sprague-Dawley rats
UR - http://www.sciencedirect.com/science/article/pii/S0306453016304930
L2 - http://www.sciencedirect.com/science/article/pii/S0306453016304930
N2 - Objective Metabolic adverse effects of atypical antipsychotics (AAP) contribute significantly to increased risk of cardiovascular morbidity and mortality in patients suffering from schizophrenia. Extensive preclinical research has addressed this issue over the past years, though mechanisms underlying these adverse effects of AAP are still not understood completely. Recently, attention is drawn towards the role of adipose tissue metabolism and neurohormonal regulations. Methods The aim of this study was to evaluate the time-dependent effects of olanzapine depot administration at clinically relevant dosing on the regulation of energy homeostasis, glucose and lipid metabolism, gastrointestinal and adipose tissue-derived hormones involved in energy balance regulations in female Sprague-Dawley rats. The study lasted 8 weeks and the markers were assayed at day 8, 15, 29, 43 and 57. Results The results indicate that in the absence of hyperphagia, olanzapine chronic exposure induced weight gain from the beginning of the study. In the later time-point, increased adiposity was also observed. In the initial phase of the study, lipid profile was altered by an early increase in triglyceride level and highly elevated leptin level was observed. Clear bi-phasic time-dependent effect of olanzapine on leptin serum concentration was demonstrated. Olanzapine treatment did not lead to changes in serum levels of ghrelin, FGF-21 and pro-inflammatory markers IL-1a, IL-6 and TNF-alpha at any time-point of the study. Conclusion This study provides data suggesting early alteration in adipose tissue endocrine function as a factor involved in mechanisms underlying metabolic adverse effects of antipsychotics.
ER -
HORSKÁ, Kateřina, Jana RUDÁ, Zuzana BABINSKÁ, Michal KARPISEK, Regina DEMLOVÁ, Radka OPATŘILOVÁ, Pavel SUCHÝ a Hana KOTOLOVÁ. Olanzapine-depot administration induces time-dependent changes inadipose tissue endocrine function in rats. \textit{Psychoneuroendocrinology}. Oxford: Pergamon-Elsevier Science LTD, 2016, roč.~73, ''neuvedeno'', s.~177-185. ISSN~0306-4530. Dostupné z: https://dx.doi.org/10.1016/j.psyneuen.2016.07.218.
|
