Four Ways to Oligonucleotides Without Phosphoimidazolides

J 2016

Four Ways to Oligonucleotides Without Phosphoimidazolides

ŠPONEROVÁ, Judit; Jiří ŠPONER a Ernesto DI MAURO

Základní údaje

Originální název

Four Ways to Oligonucleotides Without Phosphoimidazolides

Autoři

ŠPONEROVÁ, Judit; Jiří ŠPONER a Ernesto DI MAURO

Vydání

Journal of molecular evolution, New York, Springer, 2016, 0022-2844

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.434

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14740/16:00090499

Organizační jednotka

Středoevropský technologický institut

Klíčová slova anglicky

RNA; Polymerization; Origin of life; Oligonucleotides

Štítky

rivok

Změněno: 4. 8. 2016 12:48, Mgr. Eva Špillingová

Anotace

V originále

Emergence of the very first RNA or RNA-like oligomers from simple nucleotide precursors is one of the most intriguing questions of the origin of life research. In the current paper, we analyse the mechanism of four non-enzymatic template-free scenarios suggested for the oligomerization of chemically non-modified cyclic and acyclic nucleotides in the literature. We show that amines may have a twofold role in these syntheses: due to their high affinity to bind protons they may activate the phosphorus of the phosphate group via proton transfer reactions, or indirectly they may serve as charge compensating species and influence the self-assembling of nucleotides to supramolecular architectures compatible with the oligomerization reactions. Effect of cations and pH on the reactions is also discussed.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

Citovat

ŠPONEROVÁ, Judit; Jiří ŠPONER a Ernesto DI MAURO. Four Ways to Oligonucleotides Without Phosphoimidazolides. Journal of molecular evolution. New York: Springer, 2016, roč. 82, č. 1, s. 5-10. ISSN 0022-2844. Dostupné z: https://doi.org/10.1007/s00239-015-9709-5.

@article{1350876,
   author = {Šponerová, Judit and Šponer, Jiří and Di Mauro, Ernesto},
   article_location = {New York},
   article_number = {1},
   doi = {https://doi.org/10.1007/s00239-015-9709-5},
   keywords = {RNA; Polymerization; Origin of life; Oligonucleotides},
   language = {eng},
   issn = {0022-2844},
   journal = {Journal of molecular evolution},
   title = {Four Ways to Oligonucleotides Without Phosphoimidazolides},
   url = {http://link.springer.com/article/10.1007%2Fs00239-015-9709-5},
   volume = {82},
   year = {2016}
}

TY  - JOUR
ID  - 1350876
AU  - Šponerová, Judit - Šponer, Jiří - Di Mauro, Ernesto
PY  - 2016
TI  - Four Ways to Oligonucleotides Without Phosphoimidazolides
JF  - Journal of molecular evolution
VL  - 82
IS  - 1
SP  - 5-10
EP  - 5-10
PB  - Springer
SN  - 00222844
KW  - RNA
KW  - Polymerization
KW  - Origin of life
KW  - Oligonucleotides
UR  - http://link.springer.com/article/10.1007%2Fs00239-015-9709-5
L2  - http://link.springer.com/article/10.1007%2Fs00239-015-9709-5
N2  - Emergence of the very first RNA or RNA-like oligomers from simple nucleotide precursors is one of the most intriguing questions of the origin of life research. In the current paper, we analyse the mechanism of four non-enzymatic template-free scenarios suggested for the oligomerization of chemically non-modified cyclic and acyclic nucleotides in the literature. We show that amines may have a twofold role in these syntheses: due to their high affinity to bind protons they may activate the phosphorus of the phosphate group via proton transfer reactions, or indirectly they may serve as charge compensating species and influence the self-assembling of nucleotides to supramolecular architectures compatible with the oligomerization reactions. Effect of cations and pH on the reactions is also discussed.
ER  -

ŠPONEROVÁ, Judit; Jiří ŠPONER a Ernesto DI MAURO. Four Ways to Oligonucleotides Without Phosphoimidazolides. \textit{Journal of molecular evolution}. New York: Springer, 2016, roč.~82, č.~1, s.~5-10. ISSN~0022-2844. Dostupné z: https://doi.org/10.1007/s00239-015-9709-5.

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