Outcomes in Stable Patients With Previous Atherothrombotic
Events Receiving Vorapaxar Who Experience a New Acute Coronary
Event (from TRA2 degrees P-TIMI 50)

J 2016

Outcomes in Stable Patients With Previous Atherothrombotic Events Receiving Vorapaxar Who Experience a New Acute Coronary Event (from TRA2 degrees P-TIMI 50)

BERG, D.D.; M.P. BONACA; E. BRAUNWALD; R. CORBALAN; S. GOTO et al.

Základní údaje

Originální název

Outcomes in Stable Patients With Previous Atherothrombotic Events Receiving Vorapaxar Who Experience a New Acute Coronary Event (from TRA2 degrees P-TIMI 50)

Autoři

BERG, D.D.; M.P. BONACA; E. BRAUNWALD; R. CORBALAN; S. GOTO; R.G. KISS; S.A. MURPHY; B.M. SCIRICA; Jindřich ŠPINAR a D.A. MORROW

Vydání

American Journal of Cardiology, BRIDGEWATER, EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC, 2016, 0002-9149

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.398

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/16:00090675

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Vorapaxar

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 2. 2017 10:09, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Vorapaxar is a first-in-class protease-activated receptor-1 antagonist indicated for secondary prevention in stable patients with previous myocardial infarction (MI) or peripheral artery disease and no cerebrovascular disease. Vorapaxar is not recommended for initiation in the acute phase of acute coronary syndromes (ACS) because of an unfavorable balance between bleeding and efficacy when started in that setting. The aim of this analysis was to investigate outcomes in patients who experienced a new ACS while receiving vorapaxar for long-term secondary prevention. Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic ischemic Events-Thrbmbolysis In Myocardial Infarction 50 was a randomized, double-blind, placebo-controlled trial of vorapaxar (n = 26,449). We evaluated bleeding and ischemic events during the acute care of patients with a new ACS during the trial. During a median follow-up of 30 months, 799 patients (8.9%) randomized to vorapaxar and 913 (10.0%) to placebo had a new ACS event (p = 0.003); 87% and 86%, respectively, were on study therapy at the time of the event. In a landmark analysis through 7 days after ACS, the rates of Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) severe bleeding were 0.8% versus 0.8% (hazard ratio [HR] 0.99, 95% CI 0.33 to 2.94) and GUSTO moderate/severe bleeding were 2.5% versus 1.6% (HR 1.59, 95% CI 0.78 to 3.24) with vorapaxar versus placebo. The effect of vorapaxar on cardiovascular death, MI, or stroke (2.4% vs 4.4%; HR 0.54, 95% CI 0,31 to 0.93; p = 0.027) was consistent with the, overall trial result. In conclusion, in patients who experience a new ACS event while receiving vorapaxar for secondary prevention, continuing therapy was associated with favorable efficacy without excess severe bleeding during the period of acute ACS management. (C) 2016 Elsevier Inc. All rights reserved.

Citovat

BERG, D.D.; M.P. BONACA; E. BRAUNWALD; R. CORBALAN; S. GOTO; R.G. KISS; S.A. MURPHY; B.M. SCIRICA; Jindřich ŠPINAR a D.A. MORROW. Outcomes in Stable Patients With Previous Atherothrombotic Events Receiving Vorapaxar Who Experience a New Acute Coronary Event (from TRA2 degrees P-TIMI 50). American Journal of Cardiology. BRIDGEWATER: EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC, 2016, roč. 117, č. 7, s. 1055-1058. ISSN 0002-9149. Dostupné z: https://doi.org/10.1016/j.amjcard.2015.12.052.

@article{1352783,
   author = {Berg, D.D. and Bonaca, M.P. and Braunwald, E. and Corbalan, R. and Goto, S. and Kiss, R.G. and Murphy, S.A. and Scirica, B.M. and Špinar, Jindřich and Morrow, D.A.},
   article_location = {BRIDGEWATER},
   article_number = {7},
   doi = {https://doi.org/10.1016/j.amjcard.2015.12.052},
   keywords = {Vorapaxar},
   language = {eng},
   issn = {0002-9149},
   journal = {American Journal of Cardiology},
   title = {Outcomes in Stable Patients With Previous Atherothrombotic Events Receiving Vorapaxar Who Experience a New Acute Coronary Event (from TRA2 degrees P-TIMI 50)},
   volume = {117},
   year = {2016}
}

TY  - JOUR
ID  - 1352783
AU  - Berg, D.D. - Bonaca, M.P. - Braunwald, E. - Corbalan, R. - Goto, S. - Kiss, R.G. - Murphy, S.A. - Scirica, B.M. - Špinar, Jindřich - Morrow, D.A.
PY  - 2016
TI  - Outcomes in Stable Patients With Previous Atherothrombotic Events Receiving Vorapaxar Who Experience a New Acute Coronary Event (from TRA2 degrees P-TIMI 50)
JF  - American Journal of Cardiology
VL  - 117
IS  - 7
SP  - 1055-1058
EP  - 1055-1058
PB  - EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
SN  - 00029149
KW  - Vorapaxar
N2  - Vorapaxar is a first-in-class protease-activated receptor-1 antagonist indicated for secondary prevention in stable patients with previous myocardial infarction (MI) or peripheral artery disease and no cerebrovascular disease. Vorapaxar is not recommended for initiation in the acute phase of acute coronary syndromes (ACS) because of an unfavorable balance between bleeding and efficacy when started in that setting. The aim of this analysis was to investigate outcomes in patients who experienced a new ACS while receiving vorapaxar for long-term secondary prevention. Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic ischemic Events-Thrbmbolysis In Myocardial Infarction 50 was a randomized, double-blind, placebo-controlled trial of vorapaxar (n = 26,449). We evaluated bleeding and ischemic events during the acute care of patients with a new ACS during the trial. During a median follow-up of 30 months, 799 patients (8.9%) randomized to vorapaxar and 913 (10.0%) to placebo had a new ACS event (p = 0.003); 87% and 86%, respectively, were on study therapy at the time of the event. In a landmark analysis through 7 days after ACS, the rates of Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) severe bleeding were 0.8% versus 0.8% (hazard ratio [HR] 0.99, 95% CI 0.33 to 2.94) and GUSTO moderate/severe bleeding were 2.5% versus 1.6% (HR 1.59, 95% CI 0.78 to 3.24) with vorapaxar versus placebo. The effect of vorapaxar on cardiovascular death, MI, or stroke (2.4% vs 4.4%; HR 0.54, 95% CI 0,31 to 0.93; p = 0.027) was consistent with the, overall trial result. In conclusion, in patients who experience a new ACS event while receiving vorapaxar for secondary prevention, continuing therapy was associated with favorable efficacy without excess severe bleeding during the period of acute ACS management. (C) 2016 Elsevier Inc. All rights reserved.
ER  -

BERG, D.D.; M.P. BONACA; E. BRAUNWALD; R. CORBALAN; S. GOTO; R.G. KISS; S.A. MURPHY; B.M. SCIRICA; Jindřich ŠPINAR a D.A. MORROW. Outcomes in Stable Patients With Previous Atherothrombotic Events Receiving Vorapaxar Who Experience a New Acute Coronary Event (from TRA2 degrees P-TIMI 50). \textit{American Journal of Cardiology}. BRIDGEWATER: EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC, 2016, roč.~117, č.~7, s.~1055-1058. ISSN~0002-9149. Dostupné z: https://doi.org/10.1016/j.amjcard.2015.12.052.

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