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@inproceedings{1353254, author = {Hajnal, Matej and Šafránek, David and Demko, Martin and Pastva, Samuel and Krejčí, Pavel and Brim, Luboš}, address = {Neuveden}, booktitle = {Hybrid Systems Biology. HSB 2016}, doi = {http://dx.doi.org/10.1007/978-3-319-47151-8_4}, edition = {LNBI 9957}, editor = {Eugenio Cinquemani}, keywords = {signalling pathways; systems biology; parameter synthesis; dynamical systems; parameter estimation}, howpublished = {tištěná verze "print"}, language = {eng}, location = {Neuveden}, isbn = {978-3-319-47150-1}, pages = {57-66}, publisher = {Springer International Publishing}, title = {Toward Modelling and Analysis of Transient and Sustained Behaviour of Signalling Pathways}, year = {2016} }
TY - JOUR ID - 1353254 AU - Hajnal, Matej - Šafránek, David - Demko, Martin - Pastva, Samuel - Krejčí, Pavel - Brim, Luboš PY - 2016 TI - Toward Modelling and Analysis of Transient and Sustained Behaviour of Signalling Pathways PB - Springer International Publishing CY - Neuveden SN - 9783319471501 KW - signalling pathways KW - systems biology KW - parameter synthesis KW - dynamical systems KW - parameter estimation N2 - Signalling pathways provide a complex cellular information processing machinery that evaluates particular input stimuli and transfers them into the genome by means of regulation of specific genes expression. In this short paper, we provide a preliminary study targeting minimal models representing the topology of main signalling mechanisms. A special emphasis is given to distinguishing between monotonous (sustained) and non-monotonous (transient) time-course behaviour. A set of minimal parametrised ODE models is formulated and analysed in a workflow based on formal methods. ER -
HAJNAL, Matej, David ŠAFRÁNEK, Martin DEMKO, Samuel PASTVA, Pavel KREJČÍ and Luboš BRIM. Toward Modelling and Analysis of Transient and Sustained Behaviour of Signalling Pathways. In Eugenio Cinquemani. \textit{Hybrid Systems Biology. HSB 2016}. LNBI 9957. Neuveden: Springer International Publishing, 2016, p.~57-66. ISBN~978-3-319-47150-1. Available from: https://dx.doi.org/10.1007/978-3-319-47151-8\_{}4.
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