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@article{1353410,
author = {Procházková Schrumpfová, Petra and Stražická, Ivona and Hapala, Jan and Schořová, Šárka and Dvořáček, Vojtěch and Fajkus, Jiří},
article_location = {Dordrecht},
article_number = {1-2},
doi = {http://dx.doi.org/10.1007/s11103-015-0409-8},
keywords = {Telomere repeat binding (TRB); ChIP-seq; Arabidopsis thaliana; Ribosome; snoRNA; Translation machinery},
language = {eng},
issn = {0167-4412},
journal = {Plant Molecular Biology},
title = {Telomere binding protein TRB1 is associated with promoters of translation machinery genes in vivo},
url = {http://link.springer.com/article/10.1007%2Fs11103-015-0409-8},
volume = {90},
year = {2016}
}
TY - JOUR
ID - 1353410
AU - Procházková Schrumpfová, Petra - Stražická, Ivona - Hapala, Jan - Schořová, Šárka - Dvořáček, Vojtěch - Fajkus, Jiří
PY - 2016
TI - Telomere binding protein TRB1 is associated with promoters of translation machinery genes in vivo
JF - Plant Molecular Biology
VL - 90
IS - 1-2
SP - 189-206
EP - 189-206
PB - SPRINGER
SN - 01674412
KW - Telomere repeat binding (TRB)
KW - ChIP-seq
KW - Arabidopsis thaliana
KW - Ribosome
KW - snoRNA
KW - Translation machinery
UR - http://link.springer.com/article/10.1007%2Fs11103-015-0409-8
L2 - http://link.springer.com/article/10.1007%2Fs11103-015-0409-8
N2 - Recently we characterised TRB1, a protein from a single-myb-histone family, as a structural and functional component of telomeres in Arabidopsis thaliana. TRB proteins, besides their ability to bind specifically to telomeric DNA using their N-terminally positioned myb-like domain of the same type as in human shelterin proteins TRF1 or TRF2, also possess a histone-like domain which is involved in protein-protein interactions e.g., with POT1b. Here we set out to investigate the genome-wide localization pattern of TRB1 to reveal its preferential sites of binding to chromatin in vivo and its potential functional roles in the genome-wide context. Our results demonstrate that TRB1 is preferentially associated with promoter regions of genes involved in ribosome biogenesis, in addition to its roles at telomeres. This preference coincides with the frequent occurrence of telobox motifs in the upstream regions of genes in this category, but it is not restricted to the presence of a telobox. We conclude that TRB1 shows a specific genome-wide distribution pattern which suggests its role in regulation of genes involved in biogenesis of the translational machinery, in addition to its preferential telomeric localization.
ER -
PROCHÁZKOVÁ SCHRUMPFOVÁ, Petra, Ivona STRAŽICKÁ, Jan HAPALA, Šárka SCHOŘOVÁ, Vojtěch DVOŘÁČEK a Jiří FAJKUS. Telomere binding protein TRB1 is associated with promoters of translation machinery genes in vivo. \textit{Plant Molecular Biology}. Dordrecht: SPRINGER, 2016, roč.~90, 1-2, s.~189-206. ISSN~0167-4412. Dostupné z: https://dx.doi.org/10.1007/s11103-015-0409-8.
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