Genetic risk factors of cisplatin induced ototoxicity in adult
patients

J 2016

Genetic risk factors of cisplatin induced ototoxicity in adult patients

TALACH, Tomáš; Jan ROTTENBERG; Břetislav GÁL; Rom KOSTŘICA; Michal JURAJDA et. al.

Základní údaje

Originální název

Genetic risk factors of cisplatin induced ototoxicity in adult patients

Autoři

TALACH, Tomáš (203 Česká republika, garant, domácí); Jan ROTTENBERG (203 Česká republika, domácí); Břetislav GÁL (203 Česká republika, domácí); Rom KOSTŘICA (203 Česká republika, domácí); Michal JURAJDA (203 Česká republika, domácí); I. KOCAK (203 Česká republika); R. LAKOMY (203 Česká republika) a E. VOGAZIANOS (826 Velká Británie a Severní Irsko)

Vydání

Neoplasma, Bratislava, Slovenská akademie vied, 2016, 0028-2685

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Slovensko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.871

Kód RIV

RIV/00216224:14110/16:00088880

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.4149/212_140820n391

UT WoS

000375340400012

EID Scopus

2-s2.0-84969730628

Klíčová slova anglicky

cisplatin; ototoxicity; DNA copy number variations; single nucleotide polymorphisms

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 2. 2017 09:58, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Ototoxicity is an important adverse effect of using Cisplatin (cis-diamminedichloroplatinum) (CDDP) as a form of chemotherapy. The clinical picture of CDDP induced ototoxicity includes perceptive hearing impairment (reversible or permanent) and tinnitus. Ototoxicity manifests with considerable variability between patients. The objective of this prospective study was to investigate a possible genetic background to this variability. We assessed ototoxicity induced by therapeutic doses of CDDP in adult patients with germinative testicular tumors, or other tumors treated with an identical CDDP dosage scheme. Audiological examination before, during and after the treatment has shown deterioration in hearing; first in the high-frequencies and with increased CDDP cumulative doses, impairment in other frequencies as well. Occurrence of tinnitus was not dependent on the administered dose of CDDP, or the other risk factors examined in this study. The association of CDDP induced ototoxicity with genetic polymorphisms in candidate genes was examined. Our study has demonstrated an association of early onset of CDDP induced ototoxicity with the presence of two copies of GSTT1 gene (p=0,009) and with T allele of rs9332377 polymorphism in COMT gene (p=0,001).

Návaznosti

NS10101, projekt VaV

Název: Genetické aspekty ototoxicity indukované cisplatinou - prospektivní asociační studie

Investor: Ministerstvo zdravotnictví ČR, Genetické aspekty ototoxicity indukované cisplatinou - prospektivní asociační studie

Citovat

TALACH, Tomáš; Jan ROTTENBERG; Břetislav GÁL; Rom KOSTŘICA; Michal JURAJDA; I. KOCAK; R. LAKOMY a E. VOGAZIANOS. Genetic risk factors of cisplatin induced ototoxicity in adult patients. Neoplasma. Bratislava: Slovenská akademie vied, 2016, roč. 63, č. 2, s. 263-268. ISSN 0028-2685. Dostupné z: https://dx.doi.org/10.4149/212_140820n391.

@article{1353554,
   author = {Talach, Tomáš and Rottenberg, Jan and Gál, Břetislav and Kostřica, Rom and Jurajda, Michal and Kocak, I. and Lakomy, R. and Vogazianos, E.},
   article_location = {Bratislava},
   article_number = {2},
   doi = {http://dx.doi.org/10.4149/212_140820n391},
   keywords = {cisplatin; ototoxicity; DNA copy number variations; single nucleotide polymorphisms},
   language = {eng},
   issn = {0028-2685},
   journal = {Neoplasma},
   title = {Genetic risk factors of cisplatin induced ototoxicity in adult patients},
   url = {http://dx.doi.org/10.4149/212_140820N391},
   volume = {63},
   year = {2016}
}

TY  - JOUR
ID  - 1353554
AU  - Talach, Tomáš - Rottenberg, Jan - Gál, Břetislav - Kostřica, Rom - Jurajda, Michal - Kocak, I. - Lakomy, R. - Vogazianos, E.
PY  - 2016
TI  - Genetic risk factors of cisplatin induced ototoxicity in adult patients
JF  - Neoplasma
VL  - 63
IS  - 2
SP  - 263-268
EP  - 263-268
PB  - Slovenská akademie vied
SN  - 00282685
KW  - cisplatin
KW  - ototoxicity
KW  - DNA copy number variations
KW  - single nucleotide polymorphisms
UR  - http://dx.doi.org/10.4149/212_140820N391
N2  - Ototoxicity is an important adverse effect of using Cisplatin (cis-diamminedichloroplatinum) (CDDP) as a form of chemotherapy. The clinical picture of CDDP induced ototoxicity includes perceptive hearing impairment (reversible or permanent) and tinnitus. Ototoxicity manifests with considerable variability between patients. The objective of this prospective study was to investigate a possible genetic background to this variability. We assessed ototoxicity induced by therapeutic doses of CDDP in adult patients with germinative testicular tumors, or other tumors treated with an identical CDDP dosage scheme. Audiological examination before, during and after the treatment has shown deterioration in hearing; first in the high-frequencies and with increased CDDP cumulative doses, impairment in other frequencies as well. Occurrence of tinnitus was not dependent on the administered dose of CDDP, or the other risk factors examined in this study. The association of CDDP induced ototoxicity with genetic polymorphisms in candidate genes was examined. Our study has demonstrated an association of early onset of CDDP induced ototoxicity with the presence of two copies of GSTT1 gene (p=0,009) and with T allele of rs9332377 polymorphism in COMT gene (p=0,001).
ER  -

TALACH, Tomáš; Jan ROTTENBERG; Břetislav GÁL; Rom KOSTŘICA; Michal JURAJDA; I. KOCAK; R. LAKOMY a E. VOGAZIANOS. Genetic risk factors of cisplatin induced ototoxicity in adult patients. \textit{Neoplasma}. Bratislava: Slovenská akademie vied, 2016, roč.~63, č.~2, s.~263-268. ISSN~0028-2685. Dostupné z: https://dx.doi.org/10.4149/212\_{}140820n391.

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