Hyaluronan polymeric micelles for topical drug delivery

J 2017

Hyaluronan polymeric micelles for topical drug delivery

ŠMEJKALOVÁ, Daniela; Kristina NEŠPOROVÁ; Tomáš MUTHNÝ; Martina HERMANNOVÁ; Eva ACHBERGEROVÁ et al.

Základní údaje

Originální název

Hyaluronan polymeric micelles for topical drug delivery

Autoři

Vydání

Carbohydrate Polymers, Oxford, ELSEVIER SCI LTD, 2017, 0144-8617

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30105 Physiology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.158

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/17:00108671

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

Skin penetration; Polymeric micelle; Hyaluronan

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 5. 2020 11:20, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Nanosized materials offer promising strategy for topical drug delivery due to their enhancing effect on drug percutaneous transport across the stratum corneum barrier. In this work, polymeric micelles made from hydrophobized hyaluronic acid (HA) were probed for skin delivery. Compared to non-polymeric micelle solutions containing similar drug amount, in vitro skin penetration analysis indicated 3 times larger deposition of drug in the epidermis and 6 times larger drug deposition in the dermis after 5 h of topical treatment in Franz diffusion cells. The drug deposition was further increased with prolonged time of topical treatment. Laser confocal microscopy revealed the accumulation of both, the HA forming the vehicle and the payload, in the epidermis and dermis. Although fluorescent labeling of the HA would suggest co-transport of the HA and the drug, loading FRET pair dyes in the micellar core clearly demonstrated gradual micelle disruption with increasing skin depth. Transcellular penetration was the predominant pathway for the loaded drug. The HA polymeric micelles also demonstrated increased bioactivity of loaded compound in vitro and in vivo. In addition, the loaded micelles were found to be stable in cream formulations and thus they have great potential for topical applications for cosmetic and pharmaceutical purposes.

Citovat

ŠMEJKALOVÁ, Daniela; Kristina NEŠPOROVÁ; Tomáš MUTHNÝ; Martina HERMANNOVÁ; Eva ACHBERGEROVÁ; Gloria HUERTA-ANGELES; Marek SVOBODA; Martin ČEPA; Veronika MACHALOVÁ; Dominika LUPTÁKOVÁ a Vladimír VELEBNÝ. Hyaluronan polymeric micelles for topical drug delivery. Carbohydrate Polymers. Oxford: ELSEVIER SCI LTD, 2017, roč. 156, JAN, s. 86-96. ISSN 0144-8617. Dostupné z: https://doi.org/10.1016/j.carbpol.2016.09.013.

@article{1354551,
   author = {Šmejkalová, Daniela and Nešporová, Kristina and Muthný, Tomáš and Hermannová, Martina and Achbergerová, Eva and HuertaandAngeles, Gloria and Svoboda, Marek and Čepa, Martin and Machalová, Veronika and Luptáková, Dominika and Velebný, Vladimír},
   article_location = {Oxford},
   article_number = {JAN},
   doi = {https://doi.org/10.1016/j.carbpol.2016.09.013},
   keywords = {Skin penetration; Polymeric micelle; Hyaluronan},
   language = {eng},
   issn = {0144-8617},
   journal = {Carbohydrate Polymers},
   title = {Hyaluronan polymeric micelles for topical drug delivery},
   url = {http://www.sciencedirect.com/science/article/pii/S0144861716310670},
   volume = {156},
   year = {2017}
}

TY  - JOUR
ID  - 1354551
AU  - Šmejkalová, Daniela - Nešporová, Kristina - Muthný, Tomáš - Hermannová, Martina - Achbergerová, Eva - Huerta-Angeles, Gloria - Svoboda, Marek - Čepa, Martin - Machalová, Veronika - Luptáková, Dominika - Velebný, Vladimír
PY  - 2017
TI  - Hyaluronan polymeric micelles for topical drug delivery
JF  - Carbohydrate Polymers
VL  - 156
IS  - JAN
SP  - 86-96
EP  - 86-96
PB  - ELSEVIER SCI LTD
SN  - 01448617
KW  - Skin penetration
KW  - Polymeric micelle
KW  - Hyaluronan
UR  - http://www.sciencedirect.com/science/article/pii/S0144861716310670
L2  - http://www.sciencedirect.com/science/article/pii/S0144861716310670
N2  - Nanosized materials offer promising strategy for topical drug delivery due to their enhancing effect on drug percutaneous transport across the stratum corneum barrier. In this work, polymeric micelles made from hydrophobized hyaluronic acid (HA) were probed for skin delivery. Compared to non-polymeric micelle solutions containing similar drug amount, in vitro skin penetration analysis indicated 3 times larger deposition of drug in the epidermis and 6 times larger drug deposition in the dermis after 5 h of topical treatment in Franz diffusion cells. The drug deposition was further increased with prolonged time of topical treatment. Laser confocal microscopy revealed the accumulation of both, the HA forming the vehicle and the payload, in the epidermis and dermis. Although fluorescent labeling of the HA would suggest co-transport of the HA and the drug, loading FRET pair dyes in the micellar core clearly demonstrated gradual micelle disruption with increasing skin depth. Transcellular penetration was the predominant pathway for the loaded drug. The HA polymeric micelles also demonstrated increased bioactivity of loaded compound in vitro and in vivo. In addition, the loaded micelles were found to be stable in cream formulations and thus they have great potential for topical applications for cosmetic and pharmaceutical purposes.
ER  -

ŠMEJKALOVÁ, Daniela; Kristina NEŠPOROVÁ; Tomáš MUTHNÝ; Martina HERMANNOVÁ; Eva ACHBERGEROVÁ; Gloria HUERTA-ANGELES; Marek SVOBODA; Martin ČEPA; Veronika MACHALOVÁ; Dominika LUPTÁKOVÁ a Vladimír VELEBNÝ. Hyaluronan polymeric micelles for topical drug delivery. \textit{Carbohydrate Polymers}. Oxford: ELSEVIER SCI LTD, 2017, roč.~156, JAN, s.~86-96. ISSN~0144-8617. Dostupné z: https://doi.org/10.1016/j.carbpol.2016.09.013.

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