Mitochondrial dysfunction in DDR-related cancer predisposition
syndromes

J 2016

Mitochondrial dysfunction in DDR-related cancer predisposition syndromes

LYAKHOVICH, Alex, Dmitry GRAIFER, Barbora ŠTEFANOVIE a Lumír KREJČÍ

Základní údaje

Originální název

Mitochondrial dysfunction in DDR-related cancer predisposition syndromes

Autoři

LYAKHOVICH, Alex (643 Rusko, domácí), Dmitry GRAIFER (643 Rusko), Barbora ŠTEFANOVIE (703 Slovensko, domácí) a Lumír KREJČÍ (203 Česká republika, garant, domácí)

Vydání

Biochimica et Biophysica Acta - Reviews on Cancer, Amsterdam, Elsevier Science BV, 2016, 0304-419X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 9.452

Kód RIV

RIV/00216224:14110/16:00088203

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.bbcan.2016.02.006

UT WoS

000376546200010

Klíčová slova anglicky

Mitochondrial dysfunction; DNA damage and repair; Cancer predisposition syndromes; Oxidative stress; ROS; Autophagy; Mitophagy

Štítky

EL OK, podil

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 10. 2016 11:06, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Given the key role of mitochondria in various cellular events, it is not surprising that mitochondrial dysfunction (MDF) is seen in many pathological conditions, in particular cancer. The mechanisms defining MDF are not clearly understood and may involve genetic defects, misbalance of reactive oxygen species (ROS), impaired autophagy (mitophagy), acquired mutations in mitochondrial or nuclear DNA and inability of cells to cope with the consequences. The importance of MDF arises from its detection in the syndromes with defective DNA damage response (DDR) and cancer predisposition. Here, we will focus on the dual role of these syndromes in cancer predisposition and MDF with specific emphasis on impaired autophagy. (C) 2016 Elsevier B.V. All rights reserved.

Návaznosti

GAP207/12/2323, projekt VaV

Název: Endonuleazová a translokázová aktivita v restričních-modifikáčních komplexéch typu I

Investor: Grantová agentura ČR, Endonuleázová a translokázová aktivita v restrikčních-modifikačních komplexech typu I

GA13-26629S, projekt VaV

Název: SUMO a stability genomu

Investor: Grantová agentura ČR, SUMO a stability genomu

MUNI/M/1894/2014, interní kód MU

Název: Development of new MUS81 nuclease inhibitors as chemical biology probe with clinical progression

Investor: Masarykova univerzita, Development of new MUS81 nuclease inhibitors as chemical biology probe with clinical progression, INTERDISCIPLINARY - Mezioborové výzkumné projekty

Citovat

LYAKHOVICH, Alex, Dmitry GRAIFER, Barbora ŠTEFANOVIE a Lumír KREJČÍ. Mitochondrial dysfunction in DDR-related cancer predisposition syndromes. Biochimica et Biophysica Acta - Reviews on Cancer. Amsterdam: Elsevier Science BV, 2016, roč. 1865, č. 2, s. 184-189. ISSN 0304-419X. Dostupné z: https://dx.doi.org/10.1016/j.bbcan.2016.02.006.

@article{1355895,
   author = {Lyakhovich, Alex and Graifer, Dmitry and Štefanovie, Barbora and Krejčí, Lumír},
   article_location = {Amsterdam},
   article_number = {2},
   doi = {http://dx.doi.org/10.1016/j.bbcan.2016.02.006},
   keywords = {Mitochondrial dysfunction; DNA damage and repair; Cancer predisposition syndromes; Oxidative stress; ROS; Autophagy; Mitophagy},
   language = {eng},
   issn = {0304-419X},
   journal = {Biochimica et Biophysica Acta - Reviews on Cancer},
   title = {Mitochondrial dysfunction in DDR-related cancer predisposition syndromes},
   volume = {1865},
   year = {2016}
}

TY  - JOUR
ID  - 1355895
AU  - Lyakhovich, Alex - Graifer, Dmitry - Štefanovie, Barbora - Krejčí, Lumír
PY  - 2016
TI  - Mitochondrial dysfunction in DDR-related cancer predisposition syndromes
JF  - Biochimica et Biophysica Acta - Reviews on Cancer
VL  - 1865
IS  - 2
SP  - 184-189
EP  - 184-189
PB  - Elsevier Science BV
SN  - 0304419X
KW  - Mitochondrial dysfunction
KW  - DNA damage and repair
KW  - Cancer predisposition syndromes
KW  - Oxidative stress
KW  - ROS
KW  - Autophagy
KW  - Mitophagy
N2  - Given the key role of mitochondria in various cellular events, it is not surprising that mitochondrial dysfunction (MDF) is seen in many pathological conditions, in particular cancer. The mechanisms defining MDF are not clearly understood and may involve genetic defects, misbalance of reactive oxygen species (ROS), impaired autophagy (mitophagy), acquired mutations in mitochondrial or nuclear DNA and inability of cells to cope with the consequences. The importance of MDF arises from its detection in the syndromes with defective DNA damage response (DDR) and cancer predisposition. Here, we will focus on the dual role of these syndromes in cancer predisposition and MDF with specific emphasis on impaired autophagy. (C) 2016 Elsevier B.V. All rights reserved.
ER  -

LYAKHOVICH, Alex, Dmitry GRAIFER, Barbora ŠTEFANOVIE a Lumír KREJČÍ. Mitochondrial dysfunction in DDR-related cancer predisposition syndromes. \textit{Biochimica et Biophysica Acta - Reviews on Cancer}. Amsterdam: Elsevier Science BV, 2016, roč.~1865, č.~2, s.~184-189. ISSN~0304-419X. Dostupné z: https://dx.doi.org/10.1016/j.bbcan.2016.02.006.

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