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@article{1355895,
author = {Lyakhovich, Alex and Graifer, Dmitry and Štefanovie, Barbora and Krejčí, Lumír},
article_location = {Amsterdam},
article_number = {2},
doi = {http://dx.doi.org/10.1016/j.bbcan.2016.02.006},
keywords = {Mitochondrial dysfunction; DNA damage and repair; Cancer predisposition syndromes; Oxidative stress; ROS; Autophagy; Mitophagy},
language = {eng},
issn = {0304-419X},
journal = {Biochimica et Biophysica Acta - Reviews on Cancer},
title = {Mitochondrial dysfunction in DDR-related cancer predisposition syndromes},
volume = {1865},
year = {2016}
}
TY - JOUR
ID - 1355895
AU - Lyakhovich, Alex - Graifer, Dmitry - Štefanovie, Barbora - Krejčí, Lumír
PY - 2016
TI - Mitochondrial dysfunction in DDR-related cancer predisposition syndromes
JF - Biochimica et Biophysica Acta - Reviews on Cancer
VL - 1865
IS - 2
SP - 184-189
EP - 184-189
PB - Elsevier Science BV
SN - 0304419X
KW - Mitochondrial dysfunction
KW - DNA damage and repair
KW - Cancer predisposition syndromes
KW - Oxidative stress
KW - ROS
KW - Autophagy
KW - Mitophagy
N2 - Given the key role of mitochondria in various cellular events, it is not surprising that mitochondrial dysfunction (MDF) is seen in many pathological conditions, in particular cancer. The mechanisms defining MDF are not clearly understood and may involve genetic defects, misbalance of reactive oxygen species (ROS), impaired autophagy (mitophagy), acquired mutations in mitochondrial or nuclear DNA and inability of cells to cope with the consequences. The importance of MDF arises from its detection in the syndromes with defective DNA damage response (DDR) and cancer predisposition. Here, we will focus on the dual role of these syndromes in cancer predisposition and MDF with specific emphasis on impaired autophagy. (C) 2016 Elsevier B.V. All rights reserved.
ER -
LYAKHOVICH, Alex, Dmitry GRAIFER, Barbora ŠTEFANOVIE a Lumír KREJČÍ. Mitochondrial dysfunction in DDR-related cancer predisposition syndromes. Online. \textit{Biochimica et Biophysica Acta - Reviews on Cancer}. Amsterdam: Elsevier Science BV, 2016, roč.~1865, č.~2, s.~184-189. ISSN~0304-419X. Dostupné z: https://dx.doi.org/10.1016/j.bbcan.2016.02.006. [citováno 2024-04-24]
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