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@article{1355895, author = {Lyakhovich, Alex and Graifer, Dmitry and Štefanovie, Barbora and Krejčí, Lumír}, article_location = {Amsterdam}, article_number = {2}, doi = {http://dx.doi.org/10.1016/j.bbcan.2016.02.006}, keywords = {Mitochondrial dysfunction; DNA damage and repair; Cancer predisposition syndromes; Oxidative stress; ROS; Autophagy; Mitophagy}, language = {eng}, issn = {0304-419X}, journal = {Biochimica et Biophysica Acta - Reviews on Cancer}, title = {Mitochondrial dysfunction in DDR-related cancer predisposition syndromes}, volume = {1865}, year = {2016} }
TY - JOUR ID - 1355895 AU - Lyakhovich, Alex - Graifer, Dmitry - Štefanovie, Barbora - Krejčí, Lumír PY - 2016 TI - Mitochondrial dysfunction in DDR-related cancer predisposition syndromes JF - Biochimica et Biophysica Acta - Reviews on Cancer VL - 1865 IS - 2 SP - 184-189 EP - 184-189 PB - Elsevier Science BV SN - 0304419X KW - Mitochondrial dysfunction KW - DNA damage and repair KW - Cancer predisposition syndromes KW - Oxidative stress KW - ROS KW - Autophagy KW - Mitophagy N2 - Given the key role of mitochondria in various cellular events, it is not surprising that mitochondrial dysfunction (MDF) is seen in many pathological conditions, in particular cancer. The mechanisms defining MDF are not clearly understood and may involve genetic defects, misbalance of reactive oxygen species (ROS), impaired autophagy (mitophagy), acquired mutations in mitochondrial or nuclear DNA and inability of cells to cope with the consequences. The importance of MDF arises from its detection in the syndromes with defective DNA damage response (DDR) and cancer predisposition. Here, we will focus on the dual role of these syndromes in cancer predisposition and MDF with specific emphasis on impaired autophagy. (C) 2016 Elsevier B.V. All rights reserved. ER -
LYAKHOVICH, Alex, Dmitry GRAIFER, Barbora ŠTEFANOVIE a Lumír KREJČÍ. Mitochondrial dysfunction in DDR-related cancer predisposition syndromes. \textit{Biochimica et Biophysica Acta - Reviews on Cancer}. Amsterdam: Elsevier Science BV, 2016, roč.~1865, č.~2, s.~184-189. ISSN~0304-419X. Dostupné z: https://dx.doi.org/10.1016/j.bbcan.2016.02.006.
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