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@article{1356791,
author = {Radolf, Justin D. and Deka, Ranjit K. and Anand, Arvind and Šmajs, David and Norgard, Michael V. and Yang, X. Frank},
article_location = {London},
article_number = {12},
doi = {http://dx.doi.org/10.1038/nrmicro.2016.141},
keywords = {OUTER-MEMBRANE PROTEIN; PYROPHOSPHATE-DEPENDENT PHOSPHOFRUCTOKINASE; LYME-DISEASE SPIROCHETE; WHOLE GENOME SEQUENCE; BORRELIA-BURGDORFERI; SECONDARY SYPHILIS; PHOSPHOTRANSFERASE SYSTEM; BINDING PROTEIN; SUBSP PALLIDUM; ANTIGENIC VARIATION},
language = {eng},
issn = {1740-1526},
journal = {Nature Reviews Microbiology},
title = {Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen},
volume = {14},
year = {2016}
}
TY - JOUR
ID - 1356791
AU - Radolf, Justin D. - Deka, Ranjit K. - Anand, Arvind - Šmajs, David - Norgard, Michael V. - Yang, X. Frank
PY - 2016
TI - Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen
JF - Nature Reviews Microbiology
VL - 14
IS - 12
SP - 744-759
EP - 744-759
PB - Nature Publishing Group
SN - 17401526
KW - OUTER-MEMBRANE PROTEIN
KW - PYROPHOSPHATE-DEPENDENT PHOSPHOFRUCTOKINASE
KW - LYME-DISEASE SPIROCHETE
KW - WHOLE GENOME SEQUENCE
KW - BORRELIA-BURGDORFERI
KW - SECONDARY SYPHILIS
KW - PHOSPHOTRANSFERASE SYSTEM
KW - BINDING PROTEIN
KW - SUBSP PALLIDUM
KW - ANTIGENIC VARIATION
N2 - The past two decades have seen a worldwide resurgence in infections caused by Treponema pallidum subsp. pallidum, the syphilis spirochete. The well-recognized capacity of the syphilis spirochete for early dissemination and immune evasion has earned it the designation ‘the stealth pathogen’. Despite the many hurdles to studying syphilis pathogenesis, most notably the inability to culture and to genetically manipulate T. pallidum, in recent years, considerable progress has been made in elucidating the structural, physiological, and regulatory facets of T. pallidum pathogenicity. In this Review, we integrate this eclectic body of information to garner fresh insights into the highly successful parasitic lifestyles of the syphilis spirochete and related pathogenic treponemes.
ER -
RADOLF, Justin D., Ranjit K. DEKA, Arvind ANAND, David ŠMAJS, Michael V. NORGARD a X. Frank YANG. Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen. \textit{Nature Reviews Microbiology}. London: Nature Publishing Group, roč.~14, č.~12, s.~744-759. ISSN~1740-1526. doi:10.1038/nrmicro.2016.141. 2016.
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