Modeling psychiatric disorders: from genomic findings to
cellular phenotypes

J 2016

Modeling psychiatric disorders: from genomic findings to cellular phenotypes

FALK, A.; V.M. HEINE; A.J. HARWOOD; P.F. SULLIVAN; M. PEITZ et al.

Základní údaje

Originální název

Modeling psychiatric disorders: from genomic findings to cellular phenotypes

Autoři

FALK, A.; V.M. HEINE; A.J. HARWOOD; P.F. SULLIVAN; M. PEITZ; O. BRÜSTLE; S. SHEN; Yuh-Man SUN; J.C. GLOVER; D. POSTHUMA a S. DJUROVIC

Vydání

Molecular Psychiatry, London, Nature Publishing Group, 2016, 1359-4184

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 13.204

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/16:00088907

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

PLURIPOTENT STEM-CELLS; IPSC-DERIVED NEURONS; HETEROZYGOUS REELER MOUSE; AUTISM SPECTRUM DISORDERS; FIBRILLARY ACIDIC PROTEIN; DE-NOVO MUTATIONS; GENE-EXPRESSION; RETT-SYNDROME; NEURAL DEVELOPMENT; MENTAL-DISORDERS

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 14. 11. 2016 10:13, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Major programs in psychiatric genetics have identified 4150 risk loci for psychiatric disorders. These loci converge on a small number of functional pathways, which span conventional diagnostic criteria, suggesting a partly common biology underlying schizophrenia, autism and other psychiatric disorders. Nevertheless, the cellular phenotypes that capture the fundamental features of psychiatric disorders have not yet been determined. Recent advances in genetics and stem cell biology offer new prospects for cell-based modeling of psychiatric disorders. The advent of cell reprogramming and induced pluripotent stem cells (iPSC) provides an opportunity to translate genetic findings into patient-specific in vitro models. iPSC technology is less than a decade old but holds great promise for bridging the gaps between patients, genetics and biology. Despite many obvious advantages, iPSC studies still present multiple challenges. In this expert review, we critically review the challenges for modeling of psychiatric disorders, potential solutions and how iPSC technology can be used to develop an analytical framework for the evaluation and therapeutic manipulation of fundamental disease processes.

Návaznosti

NV15-31063A, projekt VaV

Název: Buněčné markery vedoucí ke specifické léčbě "na míru" schizofrenním pacientům

Citovat

FALK, A.; V.M. HEINE; A.J. HARWOOD; P.F. SULLIVAN; M. PEITZ; O. BRÜSTLE; S. SHEN; Yuh-Man SUN; J.C. GLOVER; D. POSTHUMA a S. DJUROVIC. Modeling psychiatric disorders: from genomic findings to cellular phenotypes. Molecular Psychiatry. London: Nature Publishing Group, 2016, roč. 21, č. 9, s. 1167-1179. ISSN 1359-4184. Dostupné z: https://doi.org/10.1038/mp.2016.89.

@article{1358992,
   author = {Falk, A. and Heine, V.M. and Harwood, A.J. and Sullivan, P.F. and Peitz, M. and Brüstle, O. and Shen, S. and Sun, YuhandMan and Glover, J.C. and Posthuma, D. and Djurovic, S.},
   article_location = {London},
   article_number = {9},
   doi = {https://doi.org/10.1038/mp.2016.89},
   keywords = {PLURIPOTENT STEM-CELLS; IPSC-DERIVED NEURONS; HETEROZYGOUS REELER MOUSE; AUTISM SPECTRUM DISORDERS; FIBRILLARY ACIDIC PROTEIN; DE-NOVO MUTATIONS; GENE-EXPRESSION; RETT-SYNDROME; NEURAL DEVELOPMENT; MENTAL-DISORDERS},
   language = {eng},
   issn = {1359-4184},
   journal = {Molecular Psychiatry},
   title = {Modeling psychiatric disorders: from genomic findings to cellular phenotypes},
   volume = {21},
   year = {2016}
}

TY  - JOUR
ID  - 1358992
AU  - Falk, A. - Heine, V.M. - Harwood, A.J. - Sullivan, P.F. - Peitz, M. - Brüstle, O. - Shen, S. - Sun, Yuh-Man - Glover, J.C. - Posthuma, D. - Djurovic, S.
PY  - 2016
TI  - Modeling psychiatric disorders: from genomic findings to cellular phenotypes
JF  - Molecular Psychiatry
VL  - 21
IS  - 9
SP  - 1167-1179
EP  - 1167-1179
PB  - Nature Publishing Group
SN  - 13594184
KW  - PLURIPOTENT STEM-CELLS
KW  - IPSC-DERIVED NEURONS
KW  - HETEROZYGOUS REELER MOUSE
KW  - AUTISM SPECTRUM DISORDERS
KW  - FIBRILLARY ACIDIC PROTEIN
KW  - DE-NOVO MUTATIONS
KW  - GENE-EXPRESSION
KW  - RETT-SYNDROME
KW  - NEURAL DEVELOPMENT
KW  - MENTAL-DISORDERS
N2  - Major programs in psychiatric genetics have identified 4150 risk loci for psychiatric disorders. These loci converge on a small number of functional pathways, which span conventional diagnostic criteria, suggesting a partly common biology underlying schizophrenia, autism and other psychiatric disorders. Nevertheless, the cellular phenotypes that capture the fundamental features of psychiatric disorders have not yet been determined. Recent advances in genetics and stem cell biology offer new prospects for cell-based modeling of psychiatric disorders. The advent of cell reprogramming and induced pluripotent stem cells (iPSC) provides an opportunity to translate genetic findings into patient-specific in vitro models. iPSC technology is less than a decade old but holds great promise for bridging the gaps between patients, genetics and biology. Despite many obvious advantages, iPSC studies still present multiple challenges. In this expert review, we critically review the challenges for modeling of psychiatric disorders, potential solutions and how iPSC technology can be used to develop an analytical framework for the evaluation and therapeutic manipulation of fundamental disease processes.
ER  -

FALK, A.; V.M. HEINE; A.J. HARWOOD; P.F. SULLIVAN; M. PEITZ; O. BRÜSTLE; S. SHEN; Yuh-Man SUN; J.C. GLOVER; D. POSTHUMA a S. DJUROVIC. Modeling psychiatric disorders: from genomic findings to cellular phenotypes. \textit{Molecular Psychiatry}. London: Nature Publishing Group, 2016, roč.~21, č.~9, s.~1167-1179. ISSN~1359-4184. Dostupné z: https://doi.org/10.1038/mp.2016.89.

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