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@inproceedings{1359523,
author = {Kushkevych, Ivan and Vítězová, Monika and Kollar, Peter and Jampilek, Josef},
address = {Lviv},
booktitle = {Achievements and prospects of microbiology},
edition = {Ivan Franko Lviv National Un},
keywords = {salicylamides; bowel diseases; ulcerative colitis; sulfate-reducing bacteria},
howpublished = {tištěná verze "print"},
language = {eng},
location = {Lviv},
isbn = {978-966-919-203-5},
pages = {72-74},
publisher = {Ivan Franko Lviv National University},
title = {Intestinal sulfate-reducing bacteria under the effect of salicylamides derivatives},
year = {2016}
}
TY - JOUR
ID - 1359523
AU - Kushkevych, Ivan - Vítězová, Monika - Kollar, Peter - Jampilek, Josef
PY - 2016
TI - Intestinal sulfate-reducing bacteria under the effect of salicylamides derivatives
PB - Ivan Franko Lviv National University
CY - Lviv
SN - 9789669192035
KW - salicylamides
KW - bowel diseases
KW - ulcerative colitis
KW - sulfate-reducing bacteria
N2 - Sulfate-reducing bacteria (SRB) are most likely involved in both the initiation and maintenance of the inflammatory bowel disease (IBD), unfortunately present antibacterial chemotherapeutics used in the treatment of IBD have been ineffective. Thus, the antimicrobial activity of salicylamide derivatives on two different genera of intestinal SRB, Desulfovibrio and Desulfomicrobium was investigated. Six 2-(phenylcarbamoyl)phenyl N-[(benzyloxy)carbonyl]alkanoatesand three 2-hydroxy-N-[(2S)-1-oxo-1-(phenylamino)alkan-2-yl]benzamides showed MIC values in the range from 0.22 to 0.35 microM against Desulfovibrio piger Vib-7 and in the range from 0.27 to 8.52 microM against Desulfomicrobium sp. Rod-9, which is by two orders of magnitude lower compared with ciprofloxacin.
ER -
KUSHKEVYCH, Ivan, Monika VÍTĚZOVÁ, Peter KOLLAR a Josef JAMPILEK. Intestinal sulfate-reducing bacteria under the effect of salicylamides derivatives. In \textit{Achievements and prospects of microbiology}. Ivan Franko Lviv National Un. Lviv: Ivan Franko Lviv National University, 2016, s.~72-74. ISBN~978-966-919-203-5.
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