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@article{1359792,
author = {Pontvianne, Frédéric N. and Carpentier, MarieandChristine and Durut, Nathalie and Pavlištová, Veronika and Jaške, Karin and Schořová, Šárka and Parrinello, Hugues and Rohmer, Marine and Pikaard, Craig S. and Fojtová, Miloslava and Fajkus, Jiří and SaezandVasquez, Julio Herman},
article_location = {CAMBRIDGE},
article_number = {6},
doi = {http://dx.doi.org/10.1016/j.celrep.2016.07.016},
keywords = {NUCLEAR LAMINA INTERACTIONS; TRANSFER-RNA GENES; ARABIDOPSIS INTERPHASE NUCLEI; DOSAGE CONTROL; 45S RDNA; CHROMOSOMES; TELOMERES; TRANSCRIPTION; DYNAMICS; STATES},
language = {eng},
issn = {2211-1247},
journal = {Cell Reports},
title = {Identification of Nucleolus-Associated Chromatin Domains Reveals a Role for the Nucleolus in 3D Organization of the A. thaliana Genome},
url = {http://www.sciencedirect.com/science/article/pii/S2211124716309020},
volume = {16},
year = {2016}
}
TY - JOUR
ID - 1359792
AU - Pontvianne, Frédéric N. - Carpentier, Marie-Christine - Durut, Nathalie - Pavlištová, Veronika - Jaške, Karin - Schořová, Šárka - Parrinello, Hugues - Rohmer, Marine - Pikaard, Craig S. - Fojtová, Miloslava - Fajkus, Jiří - Saez-Vasquez, Julio Herman
PY - 2016
TI - Identification of Nucleolus-Associated Chromatin Domains Reveals a Role for the Nucleolus in 3D Organization of the A. thaliana Genome
JF - Cell Reports
VL - 16
IS - 6
SP - 1574-1587
EP - 1574-1587
PB - Cell Press
SN - 22111247
KW - NUCLEAR LAMINA INTERACTIONS
KW - TRANSFER-RNA GENES
KW - ARABIDOPSIS INTERPHASE NUCLEI
KW - DOSAGE CONTROL
KW - 45S RDNA
KW - CHROMOSOMES
KW - TELOMERES
KW - TRANSCRIPTION
KW - DYNAMICS
KW - STATES
UR - http://www.sciencedirect.com/science/article/pii/S2211124716309020
L2 - http://www.sciencedirect.com/science/article/pii/S2211124716309020
N2 - The nucleolus is the site of rRNA gene transcription, rRNA processing, and ribosome biogenesis. However, the nucleolus also plays additional roles in the cell. We isolated nucleoli using fluorescence-activated cell sorting (FACS) and identified nucleolus-associated chromatin domains (NADs) by deep sequencing, comparing wild-type plants and null mutants for the nucleolar protein NUCLEOLIN 1 (NUC1). NADs are primarily genomic regions with heterochromatic signatures and include transposable elements (TEs), sub-telomeric regions, and mostly inactive protein-coding genes. However, NADs also include active rRNA genes and the entire short arm of chromosome 4 adjacent to them. In nuc1 null mutants, which alter rRNA gene expression and overall nucleolar structure, NADs are altered, telomere association with the nucleolus is decreased, and telomeres become shorter. Collectively, our studies reveal roles for NUC1 and the nucleolus in the spatial organization of chromosomes as well as telomere maintenance.
ER -
PONTVIANNE, Frédéric N., Marie-Christine CARPENTIER, Nathalie DURUT, Veronika PAVLIŠTOVÁ, Karin JAŠKE, Šárka SCHOŘOVÁ, Hugues PARRINELLO, Marine ROHMER, Craig S. PIKAARD, Miloslava FOJTOVÁ, Jiří FAJKUS a Julio Herman SAEZ-VASQUEZ. Identification of Nucleolus-Associated Chromatin Domains Reveals a Role for the Nucleolus in 3D Organization of the A. thaliana Genome. \textit{Cell Reports}. CAMBRIDGE: Cell Press, 2016, roč.~16, č.~6, s.~1574-1587. ISSN~2211-1247. Dostupné z: https://dx.doi.org/10.1016/j.celrep.2016.07.016.
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