AULICKÁ, Štefánia, Ondřej HORÁK, Lenka MRÁZOVÁ, Peter MIKOLÁŠEK, Jaroslav ŠTĚRBA, Lenka KRBKOVÁ and Hana OŠLEJŠKOVÁ. Malignant catatonia due to anti-NMDA-receptor encephalitis in a 15-year-old girl: case report and summary of current knowledge. Neuropsychiatry. London: Future Medicine Ltd., 2016, vol. 6, No 4, p. 136-141. ISSN 1758-2008. |
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@article{1361661, author = {Aulická, Štefánia and Horák, Ondřej and Mrázová, Lenka and Mikolášek, Peter and Štěrba, Jaroslav and Krbková, Lenka and Ošlejšková, Hana}, article_location = {London}, article_number = {4}, keywords = {NMDA receptor antibodies; malignant catatonia; paraneoplastic form; non-paraneoplastic form; immunotherapy}, language = {eng}, issn = {1758-2008}, journal = {Neuropsychiatry}, title = {Malignant catatonia due to anti-NMDA-receptor encephalitis in a 15-year-old girl: case report and summary of current knowledge}, volume = {6}, year = {2016} }
TY - JOUR ID - 1361661 AU - Aulická, Štefánia - Horák, Ondřej - Mrázová, Lenka - Mikolášek, Peter - Štěrba, Jaroslav - Krbková, Lenka - Ošlejšková, Hana PY - 2016 TI - Malignant catatonia due to anti-NMDA-receptor encephalitis in a 15-year-old girl: case report and summary of current knowledge JF - Neuropsychiatry VL - 6 IS - 4 SP - 136-141 EP - 136-141 PB - Future Medicine Ltd. SN - 17582008 KW - NMDA receptor antibodies KW - malignant catatonia KW - paraneoplastic form KW - non-paraneoplastic form KW - immunotherapy N2 - Anti-N-methyl-D-aspartate receptor encephalitis is a recently identified autoimmune disorder with a prominent neuropsychiatric presentation. We present the case of a 15-yearold girl with partial complex seizures with secondary generalization and acute mania with psychotic features. A positive diagnosis of anti-NMDA-receptor encephalitis suggested the specific treatment. Despite first-line immune treatment, the patient progressed to stupor, malignant catatonia, and autonomic instability with the risk of cardiopulmonary function failure. She improved after second-line immunosuppressive therapy (cyclophosphamide and rituximab simultaneously). Post-cognitive sequelae (memory impairment and deliberation) disappeared within 8 months of follow-up treatment and intensive cognitive rehabilitation. This case report emphasizes the importance of differential diagnosis and adequate treatment of catatonic syndrome, especially in young adults. Early recognition and adequate treatment is essential for a good outcome for the patients. ER -
AULICKÁ, Štefánia, Ondřej HORÁK, Lenka MRÁZOVÁ, Peter MIKOLÁŠEK, Jaroslav ŠTĚRBA, Lenka KRBKOVÁ and Hana OŠLEJŠKOVÁ. Malignant catatonia due to anti-NMDA-receptor encephalitis in a 15-year-old girl: case report and summary of current knowledge. \textit{Neuropsychiatry}. London: Future Medicine Ltd., 2016, vol.~6, No~4, p.~136-141. ISSN~1758-2008.
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