Brain activity and connectivity in response to negative
affective stimuli: Impact of dysphoric mood and sex across
diagnoses

J 2016

Brain activity and connectivity in response to negative affective stimuli: Impact of dysphoric mood and sex across diagnoses

MAREČKOVÁ, Klára, Laura M. HOLSEN, Roee ADMON, Nikos MAKRIS, Larry SEIDMAN et. al.

Základní údaje

Originální název

Brain activity and connectivity in response to negative affective stimuli: Impact of dysphoric mood and sex across diagnoses

Autoři

MAREČKOVÁ, Klára (203 Česká republika, garant, domácí), Laura M. HOLSEN (840 Spojené státy), Roee ADMON (840 Spojené státy), Nikos MAKRIS (840 Spojené státy), Larry SEIDMAN (840 Spojené státy), Stephen BUKA (840 Spojené státy), Susan WHITFIELD-GABRIELI (840 Spojené státy) a Jill M. GOLDSTEIN (840 Spojené státy)

Vydání

Human Brain mapping, Hoboken, WILEY-BLACKWELL, 2016, 1065-9471

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.530

Kód RIV

RIV/00216224:14740/16:00091932

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1002/hbm.23271

UT WoS

000386075900003

Klíčová slova anglicky

dysphoric mood state; sex; functional magnetic resonance imaging; generalized psychophysiological interaction; negative affect; International Affective Picture System; Research Domain Criteria

Štítky

rivok

Změněno: 25. 11. 2016 15:21, Mgr. Eva Špillingová

Anotace

V originále

Negative affective stimuli elicit behavioral and neural responses which vary on a continuum from adaptive to maladaptive, yet are typically investigated in a dichotomous manner (healthy controls vs. psychiatric diagnoses). This practice may limit our ability to fully capture variance from acute responses to negative affective stimuli to psychopathology at the extreme end. To address this, we conducted a functional magnetic resonance imaging study to examine the neural responses to negative valence/high arousal and neutral valence/low arousal images as a function of dysphoric mood and sex across individuals (n=99) who represented traditional categories of healthy controls, major depressive disorder, bipolar psychosis, and schizophrenia. Observation of negative (vs. neutral) stimuli elicited blood oxygen-level dependent responses in the following circuitry: periaqueductal gray, hypothalamus (HYPO), amygdala (AMYG), hippocampus (HIPP), orbitofrontal cortex (OFC), medial prefrontal cortex (mPFC), and greater connectivity between AMYG and mPFC. Across all subjects, severity of dysphoric mood was associated with hyperactivity of HYPO, and, among females, right (R) AMYG. Females also demonstrated inverse relationships between severity of dysphoric mood and connectivity between HYPO - R OFC, R AMYG - R OFC, and R AMYG - R HIPP. Overall, our findings demonstrated sex-dependent deficits in response to negative affective stimuli increasing as a function of dysphoric mood state. Females demonstrated greater inability to regulate arousal as mood became more dysphoric. These findings contribute to elucidating biosignatures associated with response to negative stimuli across disorders and suggest the importance of a sex-dependent lens in determining these biosignatures. Hum Brain Mapp 37:3733-3744, 2016. (c) 2016 Wiley Periodicals, Inc.

Návaznosti

EE2.3.30.0009, projekt VaV

Název: Zaměstnáním čerstvých absolventů doktorského studia k vědecké excelenci

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

Citovat

MAREČKOVÁ, Klára, Laura M. HOLSEN, Roee ADMON, Nikos MAKRIS, Larry SEIDMAN, Stephen BUKA, Susan WHITFIELD-GABRIELI a Jill M. GOLDSTEIN. Brain activity and connectivity in response to negative affective stimuli: Impact of dysphoric mood and sex across diagnoses. Human Brain mapping. Hoboken: WILEY-BLACKWELL, 2016, roč. 37, č. 11, s. 3733-3744. ISSN 1065-9471. Dostupné z: https://dx.doi.org/10.1002/hbm.23271.

@article{1361920,
   author = {Marečková, Klára and Holsen, Laura M. and Admon, Roee and Makris, Nikos and Seidman, Larry and Buka, Stephen and WhitfieldandGabrieli, Susan and Goldstein, Jill M.},
   article_location = {Hoboken},
   article_number = {11},
   doi = {http://dx.doi.org/10.1002/hbm.23271},
   keywords = {dysphoric mood state; sex; functional magnetic resonance imaging; generalized psychophysiological interaction; negative affect; International Affective Picture System; Research Domain Criteria},
   language = {eng},
   issn = {1065-9471},
   journal = {Human Brain mapping},
   title = {Brain activity and connectivity in response to negative affective stimuli: Impact of dysphoric mood and sex across diagnoses},
   url = {http://onlinelibrary.wiley.com/doi/10.1002/hbm.23271/epdf},
   volume = {37},
   year = {2016}
}

TY  - JOUR
ID  - 1361920
AU  - Marečková, Klára - Holsen, Laura M. - Admon, Roee - Makris, Nikos - Seidman, Larry - Buka, Stephen - Whitfield-Gabrieli, Susan - Goldstein, Jill M.
PY  - 2016
TI  - Brain activity and connectivity in response to negative affective stimuli: Impact of dysphoric mood and sex across diagnoses
JF  - Human Brain mapping
VL  - 37
IS  - 11
SP  - 3733-3744
EP  - 3733-3744
PB  - WILEY-BLACKWELL
SN  - 10659471
KW  - dysphoric mood state
KW  - sex
KW  - functional magnetic resonance imaging
KW  - generalized psychophysiological interaction
KW  - negative affect
KW  - International Affective Picture System
KW  - Research Domain Criteria
UR  - http://onlinelibrary.wiley.com/doi/10.1002/hbm.23271/epdf
L2  - http://onlinelibrary.wiley.com/doi/10.1002/hbm.23271/epdf
N2  - Negative affective stimuli elicit behavioral and neural responses which vary on a continuum from adaptive to maladaptive, yet are typically investigated in a dichotomous manner (healthy controls vs. psychiatric diagnoses). This practice may limit our ability to fully capture variance from acute responses to negative affective stimuli to psychopathology at the extreme end. To address this, we conducted a functional magnetic resonance imaging study to examine the neural responses to negative valence/high arousal and neutral valence/low arousal images as a function of dysphoric mood and sex across individuals (n=99) who represented traditional categories of healthy controls, major depressive disorder, bipolar psychosis, and schizophrenia. Observation of negative (vs. neutral) stimuli elicited blood oxygen-level dependent responses in the following circuitry: periaqueductal gray, hypothalamus (HYPO), amygdala (AMYG), hippocampus (HIPP), orbitofrontal cortex (OFC), medial prefrontal cortex (mPFC), and greater connectivity between AMYG and mPFC. Across all subjects, severity of dysphoric mood was associated with hyperactivity of HYPO, and, among females, right (R) AMYG. Females also demonstrated inverse relationships between severity of dysphoric mood and connectivity between HYPO - R OFC, R AMYG - R OFC, and R AMYG - R HIPP. Overall, our findings demonstrated sex-dependent deficits in response to negative affective stimuli increasing as a function of dysphoric mood state. Females demonstrated greater inability to regulate arousal as mood became more dysphoric. These findings contribute to elucidating biosignatures associated with response to negative stimuli across disorders and suggest the importance of a sex-dependent lens in determining these biosignatures. Hum Brain Mapp 37:3733-3744, 2016. (c) 2016 Wiley Periodicals, Inc.
ER  -

MAREČKOVÁ, Klára, Laura M. HOLSEN, Roee ADMON, Nikos MAKRIS, Larry SEIDMAN, Stephen BUKA, Susan WHITFIELD-GABRIELI a Jill M. GOLDSTEIN. Brain activity and connectivity in response to negative affective stimuli: Impact of dysphoric mood and sex across diagnoses. \textit{Human Brain mapping}. Hoboken: WILEY-BLACKWELL, 2016, roč.~37, č.~11, s.~3733-3744. ISSN~1065-9471. Dostupné z: https://dx.doi.org/10.1002/hbm.23271.

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