Prognostic Importance of Cell Cycle Regulators Cyclin D1
(CCND1) and Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B/p27)
in Sporadic Gastric Cancers

J 2016

Prognostic Importance of Cell Cycle Regulators Cyclin D1 (CCND1) and Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B/p27) in Sporadic Gastric Cancers

MINARIKOVA, Petra; Lucie BENESOVA; Tereza HALKOVA; Barbora BELSANOVA; Inna TUCKOVA et al.

Základní údaje

Originální název

Prognostic Importance of Cell Cycle Regulators Cyclin D1 (CCND1) and Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B/p27) in Sporadic Gastric Cancers

Autoři

MINARIKOVA, Petra; Lucie BENESOVA; Tereza HALKOVA; Barbora BELSANOVA; Inna TUCKOVA; Frantisek BELINA; Ladislav DUŠEK; Miroslav ZAVORAL a Marek MINARIK

Vydání

Gastroenterology Research and Practice, New York, Hindawi Publishing Corporation, 2016, 1687-6121

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.863

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/16:00092162

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1155/2016/9408190

UT WoS

000385749600001

EID Scopus

2-s2.0-84992178598

Klíčová slova anglicky

HELICOBACTER-PYLORI INFECTION; IN-SITU HYBRIDIZATION; PROBE AMPLIFICATION; THERAPEUTIC TARGET; GENE AMPLIFICATION; CYTOPLASMIC P27; BREAST-CANCER; DIFFUSE-TYPE; HER2 STATUS; CARCINOMA

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 6. 12. 2016 11:18, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Background. Gastric cancer is known for a notable variety in the course of the disease. Clinical factors, such as tumor stage, grade, and localization, are key in patient survival. It is expected that molecular factors such as somatic mutations and gene amplifications are also underlying tumor biological behavior and may serve as factors for prognosis estimation. Aim. The purpose of this study was to examine gene amplifications from a panel of genes to uncover potential prognostic marker candidates. Methods. A panel of gene amplifications including 71 genes was tested by multiplex ligation-dependent probe amplification (MLPA) technique in 76 gastric cancer samples from a Caucasian population. The correlation of gene amplification status with patient survival was determined by the Kaplan-Meier method. Results. The amplification of two cell cycle regulators, CCND1 and CDKN1B, was identified to have a negative prognostic role. The medial survival of patients with gastric cancer displaying amplification compared to patients without amplification was 192 versus 725 days for CCND1 (P = 0.0012) and 165 versus 611 days for CDKN1B (P = 0.0098). Conclusion. Gene amplifications of CCND1 and CDKN1B are potential candidates to serve as prognostic markers for the stratification of patients based on the estimate of survival in the management of gastric cancer patients.

Citovat

MINARIKOVA, Petra; Lucie BENESOVA; Tereza HALKOVA; Barbora BELSANOVA; Inna TUCKOVA; Frantisek BELINA; Ladislav DUŠEK; Miroslav ZAVORAL a Marek MINARIK. Prognostic Importance of Cell Cycle Regulators Cyclin D1 (CCND1) and Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B/p27) in Sporadic Gastric Cancers. Gastroenterology Research and Practice. New York: Hindawi Publishing Corporation, 2016, roč. 2016, č. 9408190, s. 1-8. ISSN 1687-6121. Dostupné z: https://doi.org/10.1155/2016/9408190.

@article{1363756,
   author = {Minarikova, Petra and Benesova, Lucie and Halkova, Tereza and Belsanova, Barbora and Tuckova, Inna and Belina, Frantisek and Dušek, Ladislav and Zavoral, Miroslav and Minarik, Marek},
   article_location = {New York},
   article_number = {9408190},
   doi = {https://doi.org/10.1155/2016/9408190},
   keywords = {HELICOBACTER-PYLORI INFECTION; IN-SITU HYBRIDIZATION; PROBE AMPLIFICATION; THERAPEUTIC TARGET; GENE AMPLIFICATION; CYTOPLASMIC P27; BREAST-CANCER; DIFFUSE-TYPE; HER2 STATUS; CARCINOMA},
   language = {eng},
   issn = {1687-6121},
   journal = {Gastroenterology Research and Practice},
   title = {Prognostic Importance of Cell Cycle Regulators Cyclin D1 (CCND1) and Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B/p27) in Sporadic Gastric Cancers},
   volume = {2016},
   year = {2016}
}

TY  - JOUR
ID  - 1363756
AU  - Minarikova, Petra - Benesova, Lucie - Halkova, Tereza - Belsanova, Barbora - Tuckova, Inna - Belina, Frantisek - Dušek, Ladislav - Zavoral, Miroslav - Minarik, Marek
PY  - 2016
TI  - Prognostic Importance of Cell Cycle Regulators Cyclin D1 (CCND1) and Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B/p27) in Sporadic Gastric Cancers
JF  - Gastroenterology Research and Practice
VL  - 2016
IS  - 9408190
SP  - 1-8
EP  - 1-8
PB  - Hindawi Publishing Corporation
SN  - 16876121
KW  - HELICOBACTER-PYLORI INFECTION
KW  - IN-SITU HYBRIDIZATION
KW  - PROBE AMPLIFICATION
KW  - THERAPEUTIC TARGET
KW  - GENE AMPLIFICATION
KW  - CYTOPLASMIC P27
KW  - BREAST-CANCER
KW  - DIFFUSE-TYPE
KW  - HER2 STATUS
KW  - CARCINOMA
N2  - Background. Gastric cancer is known for a notable variety in the course of the disease. Clinical factors, such as tumor stage, grade, and localization, are key in patient survival. It is expected that molecular factors such as somatic mutations and gene amplifications are also underlying tumor biological behavior and may serve as factors for prognosis estimation. Aim. The purpose of this study was to examine gene amplifications from a panel of genes to uncover potential prognostic marker candidates. Methods. A panel of gene amplifications including 71 genes was tested by multiplex ligation-dependent probe amplification (MLPA) technique in 76 gastric cancer samples from a Caucasian population. The correlation of gene amplification status with patient survival was determined by the Kaplan-Meier method. Results. The amplification of two cell cycle regulators, CCND1 and CDKN1B, was identified to have a negative prognostic role. The medial survival of patients with gastric cancer displaying amplification compared to patients without amplification was 192 versus 725 days for CCND1 (P = 0.0012) and 165 versus 611 days for CDKN1B (P = 0.0098). Conclusion. Gene amplifications of CCND1 and CDKN1B are potential candidates to serve as prognostic markers for the stratification of patients based on the estimate of survival in the management of gastric cancer patients.
ER  -

MINARIKOVA, Petra; Lucie BENESOVA; Tereza HALKOVA; Barbora BELSANOVA; Inna TUCKOVA; Frantisek BELINA; Ladislav DUŠEK; Miroslav ZAVORAL a Marek MINARIK. Prognostic Importance of Cell Cycle Regulators Cyclin D1 (CCND1) and Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B/p27) in Sporadic Gastric Cancers. \textit{Gastroenterology Research and Practice}. New York: Hindawi Publishing Corporation, 2016, roč.~2016, č.~9408190, s.~1-8. ISSN~1687-6121. Dostupné z: https://doi.org/10.1155/2016/9408190.

Přehled o publikaci