2016
Improved clinical, functional and work outcomes in spondyloarthritides during real-life adalimumab treatment in central-eastern Europe
SZÁNTÓ, Sándor, Gyula POÓR, Daniela OPRIS, Oleg IAREMENKO, Leona PROCHÁZKOVÁ et. al.Základní údaje
Originální název
Improved clinical, functional and work outcomes in spondyloarthritides during real-life adalimumab treatment in central-eastern Europe
Autoři
SZÁNTÓ, Sándor (348 Maďarsko), Gyula POÓR (348 Maďarsko), Daniela OPRIS (642 Rumunsko), Oleg IAREMENKO (804 Ukrajina), Leona PROCHÁZKOVÁ (203 Česká republika, garant, domácí), Reet KUUSE (233 Estonsko), Orsolya NAGY (348 Maďarsko), Valentyn CHERNYSHOV (112 Bělorusko) a Pál GÉHER (348 Maďarsko)
Vydání
Journal of Comparative Effectiveness Research, London, Future Medicine Ltd, 2016, 2042-6305
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30200 3.2 Clinical medicine
Stát vydavatele
Velká Británie a Severní Irsko
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 1.204
Kód RIV
RIV/00216224:14110/16:00092187
Organizační jednotka
Lékařská fakulta
UT WoS
000380807700006
Klíčová slova anglicky
adalimumab; ankylosing spondylitis; extra-articular manifestations; observational study; psoriatic arthritis; workability
Štítky
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 7. 12. 2016 11:29, Ing. Mgr. Věra Pospíšilíková
Anotace
V originále
Aim: Adalimumab effectiveness on clinical, functional and work-related outcomes was evaluated in patients with active ankylosing spondylitis or psoriatic arthritis treated in routine clinical practice in central-eastern Europe. Methods: Patients (n = 555) were followed for 12 months. Primary end point was percentage of patients with a treatment response (>= 50% decrease from baseline in Bath Ankylosing Spondylitis Disease Activity Index or >= 1.2 point decrease from baseline in Disease Activity Index-28 joint for axial or peripheral symptoms, respectively). Functional status was evaluated by the Bath Ankylosing Spondylitis Functional Index and Health Assessment Questionnaire Disability Index. Working ability was evaluated by the Work Productivity and Activity Impairment Questionnaire - Specific Health Problem. Results: 76.1% of patients with axial symptoms and 83.5% with peripheral symptoms achieved a treatment response. Frequency of extra-articular manifestations decreased. Improvements were observed in functional status and workability. No new safety signals were observed. Conclusion: Adalimumab was effective and well tolerated during real-world use in central-eastern Europe.