| BIKOS, Vasileios, Maria KARYPIDOU, Evangelia STALIKA, Panagiotis BALIAKAS, Aliki XOCHELLI, Lesley-Ann SUTTON, George PAPADOPOULOS, Andreas AGATHANGELIDIS, Evdoxia PAPADOPOULOU, Zadie DAVIS, Patricia ALGARA, George KANELLIS, Alexandra TRAVERSE-GLEHEN, Manuela MOLLEJO, Achilles ANAGNOSTOPOULOS, Maurilio PONZONI, David GONZALEZ, Šárka POSPÍŠILOVÁ, Estella MATUTES, Miguel Angel PIRIS, Theodora PAPADAKI, Paolo GHIA, Richard ROSENQUIST, David OSCIER, Nikos DARZENTAS, Dimitros TZOVARAS, Chrysoula BELESSI, Anastasia HADZIDIMITRIOU a Kostas STAMATOPOULOS. An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors. Clinical cancer research. Philadelphia: AMER ASSOC CANCER RESEARCH, 2016, roč. 22, č. 8, s. 2032-2040. ISSN 1078-0432. Dostupné z: https://dx.doi.org/10.1158/1078-0432.CCR-15-1170. |
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@article{1363889,
author = {Bikos, Vasileios and Karypidou, Maria and Stalika, Evangelia and Baliakas, Panagiotis and Xochelli, Aliki and Sutton, LesleyandAnn and Papadopoulos, George and Agathangelidis, Andreas and Papadopoulou, Evdoxia and Davis, Zadie and Algara, Patricia and Kanellis, George and TraverseandGlehen, Alexandra and Mollejo, Manuela and Anagnostopoulos, Achilles and Ponzoni, Maurilio and Gonzalez, David and Pospíšilová, Šárka and Matutes, Estella and Piris, Miguel Angel and Papadaki, Theodora and Ghia, Paolo and Rosenquist, Richard and Oscier, David and Darzentas, Nikos and Tzovaras, Dimitros and Belessi, Chrysoula and Hadzidimitriou, Anastasia and Stamatopoulos, Kostas},
article_location = {Philadelphia},
article_number = {8},
doi = {http://dx.doi.org/10.1158/1078-0432.CCR-15-1170},
keywords = {HRONIC LYMPHOCYTIC-LEUKEMIA; SOMATIC HYPERMUTATION; V-H; IMMUNOGLOBULIN GENES; DATA-COMPRESSION; CELL-RECEPTOR; LIGHT-CHAIN; SEQUENCE; MUTATION; ANTIBODIES},
language = {eng},
issn = {1078-0432},
journal = {Clinical cancer research},
title = {An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors},
url = {http://clincancerres.aacrjournals.org/content/22/8/2032},
volume = {22},
year = {2016}
}
TY - JOUR
ID - 1363889
AU - Bikos, Vasileios - Karypidou, Maria - Stalika, Evangelia - Baliakas, Panagiotis - Xochelli, Aliki - Sutton, Lesley-Ann - Papadopoulos, George - Agathangelidis, Andreas - Papadopoulou, Evdoxia - Davis, Zadie - Algara, Patricia - Kanellis, George - Traverse-Glehen, Alexandra - Mollejo, Manuela - Anagnostopoulos, Achilles - Ponzoni, Maurilio - Gonzalez, David - Pospíšilová, Šárka - Matutes, Estella - Piris, Miguel Angel - Papadaki, Theodora - Ghia, Paolo - Rosenquist, Richard - Oscier, David - Darzentas, Nikos - Tzovaras, Dimitros - Belessi, Chrysoula - Hadzidimitriou, Anastasia - Stamatopoulos, Kostas
PY - 2016
TI - An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors
JF - Clinical cancer research
VL - 22
IS - 8
SP - 2032-2040
EP - 2032-2040
PB - AMER ASSOC CANCER RESEARCH
SN - 10780432
KW - HRONIC LYMPHOCYTIC-LEUKEMIA
KW - SOMATIC HYPERMUTATION
KW - V-H
KW - IMMUNOGLOBULIN GENES
KW - DATA-COMPRESSION
KW - CELL-RECEPTOR
KW - LIGHT-CHAIN
KW - SEQUENCE
KW - MUTATION
KW - ANTIBODIES
UR - http://clincancerres.aacrjournals.org/content/22/8/2032
L2 - http://clincancerres.aacrjournals.org/content/22/8/2032
N2 - Purpose: Prompted by the extensive biases in the immunoglobulin (IG) gene repertoire of splenic marginal-zone lymphoma (SMZL), supporting antigen selection in SMZL ontogeny, we sought to investigate whether antigen involvement is also relevant post-transformation. Experimental Design: We conducted a large-scale subcloning study of the IG rearrangements of 40 SMZL cases aimed at assessing intraclonal diversification (ID) due to ongoing somatic hypermutation (SHM). Results: ID was identified in 17 of 21 (81%) rearrangements using the immunoglobulin heavy variable (IGHV) 1-2*04 gene versus 8 of 19 (40%) rearrangements utilizing other IGHV genes (P = 0.001). ID was also evident in most analyzed IG light chain gene rearrangements, albeit was more limited compared with IG heavy chains. Identical sequence changes were shared by subclones from different patients utilizing the IGHV1-2*04 gene, confirming restricted ongoing SHM profiles. Non-IGHV1-2*04 cases displayed both a lower number of ongoing SHMs and a lack of shared mutations (per group of cases utilizing the same IGHV gene). Conclusions: These findings support ongoing antigen involvement in a sizable portion of SMZL and further argue that IGHV1-2*04 SMZL may represent a distinct molecular subtype of the disease. (C) 2015 AACR.
ER -
BIKOS, Vasileios, Maria KARYPIDOU, Evangelia STALIKA, Panagiotis BALIAKAS, Aliki XOCHELLI, Lesley-Ann SUTTON, George PAPADOPOULOS, Andreas AGATHANGELIDIS, Evdoxia PAPADOPOULOU, Zadie DAVIS, Patricia ALGARA, George KANELLIS, Alexandra TRAVERSE-GLEHEN, Manuela MOLLEJO, Achilles ANAGNOSTOPOULOS, Maurilio PONZONI, David GONZALEZ, Šárka POSPÍŠILOVÁ, Estella MATUTES, Miguel Angel PIRIS, Theodora PAPADAKI, Paolo GHIA, Richard ROSENQUIST, David OSCIER, Nikos DARZENTAS, Dimitros TZOVARAS, Chrysoula BELESSI, Anastasia HADZIDIMITRIOU a Kostas STAMATOPOULOS. An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors. \textit{Clinical cancer research}. Philadelphia: AMER ASSOC CANCER RESEARCH, 2016, roč.~22, č.~8, s.~2032-2040. ISSN~1078-0432. Dostupné z: https://dx.doi.org/10.1158/1078-0432.CCR-15-1170.
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